Physiological and neuroendocrine responses to chronic variable stress in male California mice (Peromyscus californicus): Influence of social environment and paternal state

Jong, Trynke R. de; Harris, Breanna N.; Perea-Rodríguez, Juan Pablo; Saltzman, Wendy

doi:10.1016/j.psyneuen.2013.03.006

Cited by 27 publications

(30 citation statements)

References 48 publications

(63 reference statements)

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“…Third, repeated handling of animals and brief separations from their cagemates might have influenced paternal behavior and/or pup development. This seems unlikely, however, based on previous work in this species (de Jong et al 2013; Harris et al 2013). …”

Section: Discussionmentioning

confidence: 79%

“…For example, in California mice ( Peromyscus californicus ), males housed with primigravid females did not gain mass over the course of their mates’ pregnancy, whereas age-matched males housed with a nonbreeding (tubally ligated) female showed significant increases in mass (Saltzman et al 2015). Moreover, relative masses of several organs (adrenal gland, thymus, spleen) differed between California mouse fathers and non-fathers (de Jong et al 2013; see also Harris et al 2013). In prairie voles ( Microtus ochrogaster ), reductions in fat pad mass were reported in first-time fathers compared to non-fathers (Campbell et al 2009).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Consequences of Fatherhood in the Biparental California Mouse (Peromyscus californicus): Locomotor Performance, Metabolic Rate, and Organ Masses

Andrew

Saltzman

Chappell

et al. 2016

Physiological and Biochemical Zoology

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Although effects of motherhood on mothers have been well documented in mammals, the effects of fatherhood on fathers are not well known. We evaluated effects of being a father on key metabolic and performance measures in the California mouse, Peromyscus californicus. California mice are genetically monogamous in the wild, and fathers show similar parental behavior to mothers, with the exception of lactation. To investigate the impact of fatherhood on fathers, focal males were paired with an intact female (breeding males), a tubally ligated female (non-breeding males) or another male (virgins). Starting 3–5 days after the birth of each breeding pair’s first litter, males were tested for locomotor performance (maximum sprint speed, treadmill endurance), basal metabolic rate (BMR), and maximum oxygen consumption (VO2max). At the end of the 11-day test period, mice were euthanized, hematocrit determined, and organs weighed. Speed, endurance, and trueV˙O2 max were significantly repeatable between two replicate measurement days but did not differ among groups, nor did BMR. Breeding males had larger significantly hindlimb muscles than did non-breeding males, whereas virgin males had heavier subcutaneous fat pads than non-breeding and breeding males. Several correlations were observed at the level of individual variation (residuals from ANCOVA models), including positive correlations for endurance with trueV˙O2 max, trueV˙O2 max with testes mass, and some of the digestion-related organs with each other. These results indicate that fatherhood may not have pronounced performance, metabolic or morphological effects on fathers, at least under standard laboratory conditions and across a single breeding cycle.

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Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Consequences of Fatherhood in the Biparental California Mouse (Peromyscus californicus): Locomotor Performance, Metabolic Rate, and Organ Masses

Andrew

Saltzman

Chappell

et al. 2016

Physiological and Biochemical Zoology

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“…The decrease in the number of AVP –ir cells could be due to increased AVP release or decreased AVP synthesis. On the one hand, ten days of chronic mild stress increased avp mRNA in the PVN of male California mice (De Jong et al, 2013) and social defeat increased avp mRNA in the PVN of male M. musculus (Erhardt et al, 2009; Keeney et al, 2006). However, qPCR analysis revealed that stress induced an almost 3-fold decrease in baseline avp mRNA in male California mice two weeks after defeat stress.…”

Section: Discussionmentioning

confidence: 99%

Hypothalamic vasopressin systems are more sensitive to the long term effects of social defeat in males versus females

Steinman¹,

Laredo²,

López³

et al. 2015

Psychoneuroendocrinology

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Vasopressin signaling has important effects on the regulation of social behaviors and stress responses, and is considered a promising pathway to target for new therapeutics of stress-induced psychiatric disorders. Although there is evidence for sex differences in the behavioral effects of arginine vasopressin (AVP), few data have directly compared the effects of stress on endogenous AVP signaling in males and females. We used California mice (Peromyscus californicus) to study the short and long term effects of social defeat stress on AVP immunoreactive cells in the paraventricular nucleus (PVN) and the posteromedial bed nucleus of the stria terminalis (BNSTmp). Acute exposure to defeat increased AVP/c-fos cells in the PVN and SON of both males and females. In contrast, there were sex differences in the long term effects of defeat. Males but not females exposed to defeat had less avp mRNA in the PVN, and in two experiments defeat reduced the number of AVP positive cells in the caudal PVN of males but not females. Interestingly, during relatively benign social encounters with a target mouse, there was a rapid decrease in AVP percent staining (including cell bodies and fibers) in the PVN of males but not females. Defeat reduced AVP percent staining in males, but did not block the socially induced decrease in percent staining. When mice were tested in resident-intruder tests, males exposed to defeat males were no less aggressive than control males whereas aggression was abolished in females. However, bouts of aggression were positively correlated with the number of AVP neurons in the BNSTmp of control males but not stressed males, suggesting that different mechanisms mediate aggression in control and stressed males. These data show that while acute AVP responses to defeat are similar in males and females, the long term effects of defeat on AVP are stronger in males.

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“…Other studies do not report changes in CRH following repeated defeat stress (although samples were not stratified with respect to submissive behaviors) (107). However, social stress-induced increases in AVP mRNA expression have been reported by multiple groups (107–109), once again suggesting that prolonged activation of the HPA axis during social stress may be driven by this important ACTH co-secretagogue.…”

Section: Alternative Pvn Responses To Chronic Stress: Social Subordinmentioning

confidence: 96%

Paraventricular Hypothalamic Mechanisms of Chronic Stress Adaptation

2016

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The hypothalamic paraventricular nucleus (PVN) is the primary driver of hypothalamo–pituitary–adrenocortical (HPA) responses. At least part of the role of the PVN is managing the demands of chronic stress exposure. With repeated exposure to stress, hypophysiotrophic corticotropin-releasing hormone (CRH) neurons of the PVN display a remarkable cellular, synaptic, and connectional plasticity that serves to maximize the ability of the HPA axis to maintain response vigor and flexibility. At the cellular level, chronic stress enhances the production of CRH and its co-secretagogue arginine vasopressin and rearranges neurotransmitter receptor expression so as to maximize cellular excitability. There is also evidence to suggest that efficacy of local glucocorticoid feedback is reduced following chronic stress. At the level of the synapse, chronic stress enhances cellular excitability and reduces inhibitory tone. Finally, chronic stress causes a structural enhancement of excitatory innervation, increasing the density of glutamate and noradrenergic/adrenergic terminals on CRH neuronal cell somata and dendrites. Together, these neuroplastic changes favor the ability of the HPA axis to retain responsiveness even under conditions of considerable adversity. Thus, chronic stress appears able to drive PVN neurons via a number of convergent mechanisms, processes that may play a major role in HPA axis dysfunction seen in variety of stress-linked disease states.

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Physiological and neuroendocrine responses to chronic variable stress in male California mice (Peromyscus californicus): Influence of social environment and paternal state

Cited by 27 publications

References 48 publications

Consequences of Fatherhood in the Biparental California Mouse (Peromyscus californicus): Locomotor Performance, Metabolic Rate, and Organ Masses

Consequences of Fatherhood in the Biparental California Mouse (Peromyscus californicus): Locomotor Performance, Metabolic Rate, and Organ Masses

Hypothalamic vasopressin systems are more sensitive to the long term effects of social defeat in males versus females

Paraventricular Hypothalamic Mechanisms of Chronic Stress Adaptation

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