Physiological and molecular mechanisms of cold-induced improvements in glucose homeostasis in humans beyond brown adipose tissue

Beek, Sten van; Hashim, Dzhansel; Bengtsson, Tore; Hoeks, Joris

doi:10.1038/s41366-023-01270-z

Cited by 4 publications

(4 citation statements)

References 167 publications

(262 reference statements)

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“…In animal models, prolonged exposure to cold (4-10 • C) or norepinephrine infusion has been associated with an increased glucose uptake into the white adipose tissue (WAT) of rodents in both the basal-and insulin-stimulated state, and these effects persisted upon returning to thermoneutrality. It can be speculated that the increased glucose uptake is used as fuel for the increased lipolysis energy demand during cold exposure or restoration of TG lipid pool following cold exposure [30]. In persons exposed to cryogenic temperatures, the same effect may occur.…”

Section: Discussionmentioning

confidence: 99%

“…In studies on rodents and humans, shiver-induced glucose uptake has been noted in the skeletal muscles, independently of insulin secretion, which may be due to adipomyokine irisin, released as a result of muscle cell contractions [30,33,34]. Irisin affects the browning of WAT by inducing the expression of uncoupling protein 1 (UCP-1) and upregulates the expression of UCP-3 in myocytes, thereby increasing energy expenditure caused by nonshivering thermogenesis [30]. Irisin affects faster depletion of cellular energy substrates, glucose homeostasis and improves insulin sensitivity [33,34].…”

Section: Discussionmentioning

confidence: 99%

“…A significant decrease in the concentration of pro-inflammatory interleukins, such as tumour necrosis factor α (TNF-α) and interleukin 6 (IL-6), as well as an increase in the concentration of anti-inflammatory interleukin 10 (IL-10), were found after just 10 WBC procedures [39]. This effect is also beneficial within the context of improving insulin resistance, because chronically elevated levels of TNF-α and IL-6 impair the ability of insulin to stimulate intracellular glucose translocation with the use of insulin-dependent glucose transporter 4 (GLUT 4), mainly in myocytes [30]. Some researchers have also reported a decrease in CRP after 10 sessions of WBC [16,39].…”

Section: Discussionmentioning

confidence: 99%

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Whole-Body Cryotherapy Improves Asprosin Secretion and Insulin Sensitivity in Postmenopausal Women–Perspectives in the Management of Type 2 Diabetes

Wiecek,

Szymura,

Kusmierczyk

et al. 2023

Biomolecules

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Type 2 diabetes (T2DM) is a global problem. The effect of whole-body cryotherapy (WBC) on metabolism in humans is postulated. The aim of this study was to determine the effect of WBC on asprosin concentrations, glucose homeostasis and insulin resistance in postmenopausal women with T2DM. Changes in fasting blood glucose (FBG), glycated haemoglobin (HbA1c), insulin, asprosin, insulin-resistance indices (HOMA-IR, Quicki), the triglyceride–glucose index (TyG) and C-reactive protein (CRP) were determined. Determination was carried out after 30 WBCs (3 min, −120 °C), applied in six series of five treatments, with 2-day breaks in postmenopausal women with T2DM and the results were compared to changes in postmenopausal women without T2DM (CON). Blood was collected before 1 WBC (T0), after 30 WBCs (T1) and 2 weeks after their completion (T2). In the T2DM group, there was a significant decrease in FBG and HbA1c in T1 and T2, as well as a significant decrease in insulin, HOMA-IR and CRP, and an increase in the Quicki index in T2. In the CON group, the concentration of asprosin at T2 was significantly lower than at T0. There was a significantly positive correlation between asprosin and FBG and HOMA-IR, and a trend towards a decrease of asprosin concentration in T2 in postmenopausal women with T2DM.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Whole-Body Cryotherapy Improves Asprosin Secretion and Insulin Sensitivity in Postmenopausal Women–Perspectives in the Management of Type 2 Diabetes

Wiecek,

Szymura,

Kusmierczyk

et al. 2023

Biomolecules

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“…The results of research on the subject indicate that such a method may be whole-body cryotherapy (WBC). The mechanisms regarding the metabolic impact of cryogenic temperatures have not been explained so far [ 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Whole-Body Cryotherapy Alters Circulating MicroRNA Profile in Postmenopausal Women

Więcek

Kuśmierczyk

Szymura

et al. 2023

JCM

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The incidence of metabolic syndrome (MetS) increases with age, especially in women. The role of microRNAs (miRs) in the regulation of metabolism is postulated. The aim of the study is to identify miRs that may be markers of MetS and to assess changes in miRs expression as a result of 10 and 20 whole-body cryotherapy treatments (WBC; 3 min, −120 °C) in postmenopausal women with MetS (M-60, BMI 30.56 ± 5.38 kg/m2), compared to healthy postmenopausal (H-60, BMI 25.57 ± 2.46 kg/m2) and healthy young women (H-20, BMI 22.90 ± 3.19 kg/m2). In a fasting state, before 1 WBC and after 10 WBCs, as well as 20 WBCs, the expression of miR-15a-5p, miR-21-5p, miR-23a-3p, miR-146a-5p, miR-197-3p, miR-223-3p, fasting blood glucose (FBG) and blood lipid profile were determined. miR-15a-5p and miR-21-5p were down-regulated in M-60, while miR-23a-3p and miR-197-3p were up-regulated, and miR-223-3p down-regulated in M-60 and H-60, compared to H-20. Significant positive correlations between up-regulated (mostly for miR-23-3p and miR-197-3p) and significant negative correlations between down-regulated (mostly for miR-15a-5p) miRs and markers of body composition as well as metabolic disorders were observed. After 20 WBCs, miR-15a-5p expression was up-regulated in all groups. In H-60, down-regulation of miR-197-3p expression occurred after 10 WBCs and 20 WBCs. Following 10 WBCs, FBG decreased in all groups, which intensified in M-60 post-20 WBCs. In our research, it has been shown that miR-23a-3p and miR-197-3p are accurate markers of MetS and MetS risk factors, while miR-15a-5p and miR-23a-3p are precise markers of body composition disorders. WBC is an effective treatment for up-regulating miR-15a-5p and lowering glucose levels in young and postmenopausal women and down-regulating miR-197-3p expression in postmenopausal women. It may be an adjunctive effective treatment method in MetS and hyperglycemia.

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How do dynamic and time-dependent indoor temperature patterns impact on the health of office based workers? – A scoping review

Reitmayer,

Johnstone,

Madigan

et al. 2023

Building and Environment

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Physiological and molecular mechanisms of cold-induced improvements in glucose homeostasis in humans beyond brown adipose tissue

Abstract: Physiological and molecular mechanisms of cold-induced improvements in glucose homeostasis in humans beyond brown adipose tissue.

Cited by 4 publications

References 167 publications

Whole-Body Cryotherapy Improves Asprosin Secretion and Insulin Sensitivity in Postmenopausal Women–Perspectives in the Management of Type 2 Diabetes

Whole-Body Cryotherapy Improves Asprosin Secretion and Insulin Sensitivity in Postmenopausal Women–Perspectives in the Management of Type 2 Diabetes

Whole-Body Cryotherapy Alters Circulating MicroRNA Profile in Postmenopausal Women

How do dynamic and time-dependent indoor temperature patterns impact on the health of office based workers? – A scoping review

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