Physiological and metabolic approach of plastic additive effects: Immune cells responses

Burgos-Aceves, Mario Alberto; Abo‐Al‐Ela, Haitham G.; Faggio, Caterina

doi:10.1016/j.jhazmat.2020.124114

Cited by 97 publications

(28 citation statements)

References 115 publications

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“…One of these emerging alternatives is DINCH, which so far lacks a range of toxicity and endocrine disruptive assessments regarding human health. One of the missing points is the assessment of immunotoxicity, which is crucial for safety evaluation, because immune cells are ubiquitously distributed in various tissues [ 48 ] and, in general, plastic additives have been reported to affect inflammatory responses [ 3 , 49 , 50 ]. Therefore, it is necessary to study the impact of DINCH and its transformation products in immune cells, which we have done here for DINCH and its primary transformation product MINCH in THP-1 M1-like macrophages, since macrophages, as part of the innate immune response, are the first barrier to xenobiotic penetration.…”

Section: Discussionmentioning

confidence: 99%

The Emerging Plasticizer Alternative DINCH and Its Metabolite MINCH Induce Oxidative Stress and Enhance Inflammatory Responses in Human THP-1 Macrophages

Schaffert

Arnold

Karkossa

et al. 2021

Cells

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The use of the plasticizer bis(2-ethylhexyl)phthalate (DEHP) and other plasticizers in the manufacture of plastic products has been restricted due to adverse health outcomes such as obesity, metabolic syndrome, and asthma, for which inflammation has been described to be a driving factor. The emerging alternative plasticizer 1,2-cyclohexanedioic acid diisononyl ester (DINCH) still lacks information regarding its potential effects on the immune system. Here, we investigated the effects of DINCH and its naturally occurring metabolite monoisononylcyclohexane-1,2-dicarboxylic acid ester (MINCH) on the innate immune response. Human THP-1 macrophages were exposed to 10 nM–10 μM DINCH or MINCH for 4 h, 16 h, and 24 h. To decipher the underlying mechanism of action, we applied an untargeted proteomic approach that revealed xenobiotic-induced activation of immune-related pathways such as the nuclear factor κB (NF-κB) signaling pathway. Key drivers were associated with oxidative stress, mitochondrial dysfunction, DNA damage repair, apoptosis, and autophagy. We verified increased reactive oxygen species (ROS) leading to cellular damage, NF-κB activation, and subsequent TNF and IL-1β release, even at low nM concentrations. Taken together, DINCH and MINCH induced cellular stress and pro-inflammatory effects in macrophages, which may lead to adverse health effects.

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Section: Discussionmentioning

confidence: 99%

The Emerging Plasticizer Alternative DINCH and Its Metabolite MINCH Induce Oxidative Stress and Enhance Inflammatory Responses in Human THP-1 Macrophages

Schaffert

Arnold

Karkossa

et al. 2021

Cells

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“…Stress is known to disrupt various physiological functions, thereby increasing disease susceptibility and suppressing immune responses (Abo-Al-Ela and Faggio 2021; Burgos-Aceves et al 2021;Dawood et al 2020;Zhang et al 2018). Corticosterone is a glucocorticoid hormone that significantly increases in the circulation during stresses in chickens (Scanes 2016).…”

Section: Transcriptomic Profile Changes Of Immune-related Genes During Stressmentioning

confidence: 99%

Stress and immunity in poultry: light management and nanotechnology as effective immune enhancers to fight stress

Abo‐Al‐Ela

El‐Kassas

El-Naggar

et al. 2021

Cell Stress and Chaperones

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The poultry industry plays a significant role in boosting the economy of several countries, particularly developing countries, and acts as a good, cheap, and affordable source of animal protein. A stress-free environment is the main target in poultry production. There are several stressors, such as cold stress, heat stress, high stocking density, and diseases that can affect birds and cause several deleterious changes. Stress reduces feed intake and growth, as well as impairs immune response and function, resulting in high disease susceptibility. These effects are correlated with higher corticosteroid levels that modulate several immune pathways such as cytokine-cytokine receptor interaction and Toll-like receptor signaling along with induction of excessive production of reactive oxygen species (ROS) and thus oxidative stress. Several approaches have been considered to boost bird immunity to overcome stress-associated effects. Of these, dietary supplementation of certain nutrients and management modifications, such as light management, are commonly considered. Dietary supplementations improve bird immunity by improving the development of lymphoid tissues and triggering beneficial immune modulators and responses. Since nano-minerals have higher bioavailability compared to inorganic or organic forms, they are highly recommended to be included in the bird's diet during stress. Additionally, light management is considered a cheap and safe approach to control stress. Changing light from continuous to intermittent and using monochromatic light instead of the normal light improve bird performance and health. Such changes in light management are associated with a reduction of ROS production and increased antioxidant production. In this review, we discuss the impact of stress on the immune system of birds and the transcriptome of oxidative stress and immune-related genes, in addition, how nano-minerals supplementations and light system modulate or mitigate stress-associated effects.

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“…To study the effects of contaminants, however, we must also know the routes by which these substances enter in organisms. In fact, contaminants can enter mussel tissues through food, respiration, or transport across biological membranes [54,78,79]. If they enter with food, the most commonly-used target tissue to study their effects is the digestive gland, which includes numerous blind-bottomed epithelial tubules composed mainly of basophilic and digestive cells.…”

Section: Mytilus Galloprovincialis: a Suitable Model Organism For The Study Of Neonicotinoidsmentioning

confidence: 99%

Impact of Neonicotinoids to Aquatic Invertebrates—In Vitro Studies on Mytilus galloprovincialis: A Review

Pagano

Stará

Aliko

et al. 2020

JMSE

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The use of pesticides in agriculture has always had a strong impact on environmental contamination. Since the 1990s, neonicotinoids have grown increasingly more popular, targeting specific receptors for insects, especially bees, which is why the use of some neonicotinoids has been banned. Much is known about the effects they have on insects, but very little about the effect they can have on non-target organisms. Several studies have shown how these neonicotinoids interact negatively with the normal physiology of aquatic organisms. For the genus Mytilus, even though the neonicotinoids did not show an interaction with specific receptors, a chronic and acute exposure to them causes damage. In these animals, a reduced production of byssus, alteration of the normal antioxidant systems and tissue damage have been found. Therefore, an analysis of the entire ecosystem in which the pollutant enters is of great importance in evaluating any possible alterations.

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Physiological and metabolic approach of plastic additive effects: Immune cells responses

Cited by 97 publications

References 115 publications

The Emerging Plasticizer Alternative DINCH and Its Metabolite MINCH Induce Oxidative Stress and Enhance Inflammatory Responses in Human THP-1 Macrophages

The Emerging Plasticizer Alternative DINCH and Its Metabolite MINCH Induce Oxidative Stress and Enhance Inflammatory Responses in Human THP-1 Macrophages

Stress and immunity in poultry: light management and nanotechnology as effective immune enhancers to fight stress

Impact of Neonicotinoids to Aquatic Invertebrates—In Vitro Studies on Mytilus galloprovincialis: A Review

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