Physiological and Histological Study to the Effects of Monosodium Glutamate in Laboratory male Rats and the protective role of vitamin E

Abstract

The current study was conducted at the Department of Biology, College of Science, Wasit University to investigate physiological and histological effect monosodium glutamate in laboratory male rats, preventive role of vitamin E. This study was carried out in Laboratories of College of Science, Wasit University, AL- Shaheed Dr. Fairooz Hospitals, from November 2017 to April 2018.The study included twenty-four and divided into four groups (six rats per group). the first group severe as a control group orally dosed with distilled water, and treated the second group (100 mg/kg b.w. Monosodium glutamate for 30 days, and the third group were dosed orally 200 mg/kg of b.w. for 30 days, either The fourth group were dosed with a mixture of Monosodium glutamate 200mg/kg and vitamin E 100 mg/kg of body weight for 30 days. after the trial period has been sacrificing animals for testing and chemical standards physiological and histological. As are result of by exposure to Monosodium glutamate in blood serum are negatively biochemical whole height of the level of serum cholesterol, triglycerides, Low-density lipoprotein, very- low density lipoprotein, liver enzymes, AST, ALT, ALP, creatinine level, urea serum, further more we noticed a decrease in high density lipoprotein. The preventive treatment resulted in vitamin E 100mg/kg b.w. with Monosodium glutamate 200 mg/kg b.w. (p≤ 0.05) in body weight and relative weights of organs (liver and kidney). We noticed a higher moral when treatment with vitamin E with Monosodium glutamate 100 mg/kg in high- density lipoprotein, while serum cholesterol level decrease, triglycerides, Low-density lipoprotein, very- low density lipoprotein. And liver and kidney functions have improved by low Enzyme AST, ALT, ALP, creatinine and urea serum level. Histological examination revealed that the liver and kidneys, of rats exposed 100, 200 mg/kg of Monosodium glutamate has been adversely affected by exposure to Monosodium glutamate. Whereas, the histological of the liver of animals treated with vitamin E with Monosodium glutamate natural pictures showed improvement. These results demonstrate that MSG toxic effects on the liver and kidney tissue. The more toxic than salt rate too. The study recommends to avoid using MSG as food additives and food for animals because of the toxic effects of this salt.

Effects of chronic administration of some bouillon cubes on oxidative stress and liver function markers in female albino rats

“…Group E (high dose Knorr) on the other hand, also showed mild blood deposit in the central vein. This study agrees with the works of Eweka et al [24] and AL-Khatawi et al [28], which reported degeneration of hepatocytes and necrosis in the liver of the treated wistar rats.…”

Toxicity of monosodium glutamate intake on different tissues induced oxidative stress: A Review

“…Studies providing evidence of MSG's toxic effects have raised the increasing interest in MSG intake as a flavor enhancer . ( 1,2) Monosodium glutamate (MSG) is the sodium salt of glutamic acid (GA), one of the most abundant naturally occurring nonessential amino acids. It is sold as a fine white crystalline substance, similar in appearance to table salt (NaCl) and sugar as shown in the next figure (A) Glutamic acid (GA) is present naturally in most foods, such as meat, poultry, seafood, and vegetables .…”

“…Neurotoxic effects on the brain, obesity, metabolic defects, and detrimental effects on sex organs are the most discussed in the connection with MSG intake, especially the effect of MSG on the liver, kidney, testis, and epididymis which might cause increased oxidative stress in the tissues of animals. (2) MSG symptoms complex include headache, muscle tightness, numbness tingling, general weakness, and flushing. severity.…”