Physiological and biochemical responses of the estuarine pulmonate mud snail, Amphibola crenata, sub-chronically exposed to waterborne cadmium

Silva, Nuwan A.L. De; Marsden, Islay D.; Gaw, Sally; Glover, Chris N.

doi:10.1016/j.aquatox.2023.106418

Cited by 6 publications

(1 citation statement)

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“…Hence, Cd selectivity of snail MTs in this context confers on them a Cd-specific function (Dallinger and Berger 1993 ; Dallinger et al 1997 ; Höckner et al 2011a , b ). In fact, most marine, freshwater and terrestrial snails have developed some Cd tolerance thanks to their MT system which, as a rule with some exemptions, accumulates and detoxifies the metal in the animals' midgut gland (Dallinger 1993 ; Bebianno and Langston 1998 ; García-Risco et al 2023 ; De Silva et al 2023 ). When the detoxification capacity of the Cd-specific MTs in the snail tissues is exhausted, the toxic effects of the metal become apparent and lead to a series of pathological alterations such as programmed cell death, disruption of cellular structures, oxidative stress, and others (Chabicovsky et al 2004 ; Hödl et al 2010 ; De Silva et al 2023 ; Gnatyshyna et al 2023 ).…”

Section: The Multifarious World Of Gastropod Mtsmentioning

confidence: 99%

Metals and metallothionein evolution in snails: a contribution to the concept of metal-specific functionality from an animal model group

Dallinger

2024

Biometals

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This is a critical review of what we know so far about the evolution of metallothioneins (MTs) in Gastropoda (snails, whelks, limpets and slugs), an important class of molluscs with over 90,000 known species. Particular attention will be paid to the evolution of snail MTs in relation to the role of some metallic trace elements (cadmium, zinc and copper) and their interaction with MTs, also compared to MTs from other animal phyla. The article also highlights the important distinction, yet close relationship, between the structural and metal-selective binding properties of gastropod MTs and their physiological functionality in the living organism. It appears that in the course of the evolution of Gastropoda, the trace metal cadmium (Cd) must have played an essential role in the development of Cd-selective MT variants. It is shown how the structures and Cd-selective binding properties in the basal gastropod clades have evolved by testing and optimizing different combinations of ancestral and novel MT domains, and how some of these domains have become established in modern and recent gastropod clades. In this context, the question of how adaptation to new habitats and lifestyles has affected the original MT traits in different gastropod lineages will also be addressed. The 3D structures and their metal binding preferences will be highlighted exemplarily in MTs of modern littorinid and helicid snails. Finally, the importance of the different metal requirements and pathways in snail tissues and cells for the shaping and functionality of the respective MT isoforms will be shown.

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