Physiological and Biochemical Effects of Pregnancy in Uninephrectomized Rabbits

Maternal and Fetal Outcomes After Living Kidney Donation

“…2 Loss to follow-up was reported as 5.5% and 3 6.4%. 4 Gestational hypertension, also known as pregnancy-induced hypertension or PIH, defined as new-onset hypertension after 20 weeks gestation (≥140 mmHg systolic or ≥90 mmHg diastolic, 5 or an increase in diastolic pressure of ≥15 mmHg compared with average measurements before 20 weeks gestation, measured twice at least 6 h apart). 6 Preeclampsia defined as gestational hypertension plus proteinuria (defined as > 300 mg/24 h or two readings of 1+ proteinuria on dipstick at least 6 h apart).…”

“…11 Nullipara is a woman who has never been previously pregnant, primipara is a woman who may have been pregnant before but has never given birth to a baby older than 20 weeks gestation, multipara is a woman who has previously given birth to at least one child. 3 Tallo CP 1995 4 (27) Rhode Island, USA 62 1988-1993 2.0 3.0 Nuojua-Huttunen S 1999 5 (28) Oulu, Finland 276 1991-1996 5.1 6.2 Koudstaal J 2000 7 (29) Amsterdam, Netherlands 307 9 (. .…”

“…There was no significant difference between the groups (1, 2 and 3) in the incidence of low birth weight (<2500 g), preterm birth (<37 weeks), still births (included fetuses 4 Not defined. 5 Gestational hypertension defined as transient hypertension without proteinuria. 6 Gestational hypertension defined as new-onset blood pressure ≥140/90 mmHg after 20 weeks of gestation or an increase in diastolic blood pressure of at least 15 mmHg or systolic blood pressure of at least 30 mmHg from the woman's average blood pressure before 20 weeks of gestation, without proteinuria.…”

“…Pregnancy is a time of net salt and water retention, with 50% increase in plasma volume and glomerular filtration rate (GFR), associated with single nephron hyperfiltration. Animal studies have demonstrated that reduced nephron mass is related to an increase in blood pressure and protein excretion in late pregnancy (5,6). In addition, human studies report higher rates of HDP in women with preexisting kidney disease (4).…”

Impact of kidney donation on pregnancy outcomes: A retrospective analysis

“…[ 3 ] It is a known fact that kidney donation as well as pregnancy lead to hyperfiltration, which seems to be a genuine concern. [ 4 5 ] Earlier studies demonstrated that pregnancies after kidney donation were not associated with increased risk of poor maternal and fetal outcomes. [ 6 7 ] Contrary to the above reports, recent studies from Norway revealed a 2.5-fold increase in the adjusted risk of preeclampsia in post-donation pregnancies,[ 8 ] while Ibrahim et al [ 9 ] observed that the risk of gestational hypertension, proteinuria, and pre-eclampsia among pregnancies after kidney donation increased with a lower likelihood of full-term delivery.…”