Physiological and behavioral responses to observing a sibling experience a direct stressor in prairie voles

Wardwell, Joshua; Watanasriyakul, W Tang; Normann, Marigny C; Akinbo, Oreoluwa I; McNeal, Neal; Ciosek, Sarah; Cox, Miranda; Holzapfel, Nicole; Sujet, Samantha; Grippo, Angela J.

doi:10.1080/10253890.2020.1724950

Cited by 11 publications

(5 citation statements)

References 49 publications

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“…The HS-HS group received the HS diet in both the periods (pre- and postweaning) resulting in adulthood hyperactivity measured by higher locomotion in the OF test. Also, this group presented an increase in the rearing frequency, which can be classified as a vertical exploration, confirming a high activity ( Borta and Schwarting, 2005 ; Wardwell et al, 2020 ). Interestingly, with a similar protocol, Mcbride et al (2008) observed that both the male Wistar rats treated with HS diet (4% NaCl) in the pre- (preconception and gestation periods) and postnatal periods (lactation) had increased locomotion in the OF test.…”

Section: Discussionmentioning

confidence: 59%

High-Salt Diet in the Pre- and Postweaning Periods Leads to Amygdala Oxidative Stress and Changes in Locomotion and Anxiety-Like Behaviors of Male Wistar Rats

Leal

Silva

Rocha-Gomes

et al. 2022

Front. Behav. Neurosci.

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High-salt (HS) diets have recently been linked to oxidative stress in the brain, a fact that may be a precursor to behavioral changes, such as those involving anxiety-like behavior. However, to the best of our knowledge, no study has evaluated the amygdala redox status after consuming a HS diet in the pre- or postweaning periods. This study aimed to evaluate the amygdala redox status and anxiety-like behaviors in adulthood, after inclusion of HS diet in two periods: preconception, gestation, and lactation (preweaning); and only after weaning (postweaning). Initially, 18 females and 9 male Wistar rats received a standard (n = 9 females and 4 males) or a HS diet (n = 9 females and 5 males) for 120 days. After mating, females continued to receive the aforementioned diets during gestation and lactation. Weaning occurred at 21-day-old Wistar rats and the male offspring were subdivided: control-control (C-C)—offspring of standard diet fed dams who received a standard diet after weaning (n = 9–11), control-HS (C-HS)—offspring of standard diet fed dams who received a HS diet after weaning (n = 9–11), HS-C—offspring of HS diet fed dams who received a standard diet after weaning (n = 9–11), and HS-HS—offspring of HS diet fed dams who received a HS diet after weaning (n = 9–11). At adulthood, the male offspring performed the elevated plus maze and open field tests. At 152-day-old Wistar rats, the offspring were euthanized and the amygdala was removed for redox state analysis. The HS-HS group showed higher locomotion and rearing frequency in the open field test. These results indicate that this group developed hyperactivity. The C-HS group had a higher ratio of entries and time spent in the open arms of the elevated plus maze test in addition to a higher head-dipping frequency. These results suggest less anxiety-like behaviors. In the analysis of the redox state, less activity of antioxidant enzymes and higher levels of the thiobarbituric acid reactive substances (TBARS) in the amygdala were shown in the amygdala of animals that received a high-salt diet regardless of the period (pre- or postweaning). In conclusion, the high-salt diet promoted hyperactivity when administered in the pre- and postweaning periods. In animals that received only in the postweaning period, the addition of salt induced a reduction in anxiety-like behaviors. Also, regardless of the period, salt provided amygdala oxidative stress, which may be linked to the observed behaviors.

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Section: Discussionmentioning

confidence: 59%

High-Salt Diet in the Pre- and Postweaning Periods Leads to Amygdala Oxidative Stress and Changes in Locomotion and Anxiety-Like Behaviors of Male Wistar Rats

Leal

Silva

Rocha-Gomes

et al. 2022

Front. Behav. Neurosci.

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“…Raw 10‐min recordings were visually inspected to remove artefacts and missed heartbeats, as done in other studies. 40 , 54 , 55 , 56 In addition, we note that on a technical level, shorter analysis periods increase variability, whereas longer HR traces give greater data and a more accurate HRV assessment. However, several studies find that briefer analysis windows can provide meaningful findings, and 5 min is often used for a briefer baseline for humans.…”

Section: Methodsmentioning

confidence: 81%

“…Raw 10‐min recordings were visually inspected to remove artefacts and missed heartbeats, as done in other studies 40,54–56 . In addition, we note that on a technical level, shorter analysis periods increase variability, whereas longer HR traces give greater data and a more accurate HRV assessment.…”

Section: Methodsmentioning

confidence: 99%

Sex differences in heart rate variability measures that predict alcohol drinking in rats

Frasier,

Starski,

de Oliveira Sergio

et al. 2024

Addiction Biology

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Problem alcohol drinking continues to be a substantial cost and burden. In addition, alcohol consumption in women has increased in recent decades, and women can have greater alcohol problems and comorbidities. Thus, there is a significant need for novel therapeutics to enhance sex‐specific, individualized treatment. Heart rate (HR) and HR variability (HRV) are of broad interest because they may be both biomarkers for and drivers of pathological states. HRV reflects the dynamic balance between sympathetic (SNS, ‘fight or flight’) and parasympathetic (PNS, ‘rest and digest’) systems. Evidence from human studies suggest PNS predominance in women and SNS in men during autonomic regulation, indicating the possibility of sex differences in risk factors and physiological drivers of problem drinking. To better understand the association between HRV sex differences and alcohol drinking, we examined whether alcohol consumption levels correlated with time domain HRV measures (SDNN and rMSSD) at baseline, at alcohol drinking onset, and across 10 min of drinking, in adult female and male Wistar rats. In particular, we compared both HRV and HR measures under alcohol‐only and compulsion‐like conditions (alcohol + 10 mg/L quinine), because compulsion can often be a significant barrier to treatment of alcohol misuse. Importantly, previous work supports the possibility that different HRV measures could be interpreted to reflect PNS versus SNS influences. Here, we show that females with higher putative PNS indicators at baseline and at drinking onset had greater alcohol consumption. In contrast, male intake levels related to increased potential SNS measures at drinking onset. Once alcohol was consumed, HR predicted intake level in females, perhaps a pharmacological effect of alcohol. However, HRV changes were greater during compulsion‐like intake versus alcohol‐only, suggesting HRV changes (reduced SNS in females, reduced PNS and increased HR in males) specifically related to aversion‐resistant intake. We find novel and likely clinically relevant autonomic differences associated with biological sex and alcohol drinking, suggesting that different autonomic mechanisms may promote differing aspects of female and male alcohol consumption.

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“…Because of this trait, many studies on social behavior have been carried out using prairie voles (reviewed by Aragona and Wang, 2004;Potretzke and Ryabinin, 2019;Tabbaa et al, 2017;Young and Wang, 2004). Previous studies suggest that prairie voles show empathy-like behavior, such as freezing caused by emotional contagion of conspecifics' fear, and consolation (Burkett et al, 2016;Stetzik et al, 2018;Wardwell et al, 2020). However, helping behavior that rescues conspecifics from distressed situations has not been elucidated in prairie voles.…”

Section: Introductionmentioning

confidence: 99%

Helping behavior in prairie voles: A model of empathy and the importance of oxytocin

et al. 2022

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Physiological and behavioral responses to observing a sibling experience a direct stressor in prairie voles

Cited by 11 publications

References 49 publications

High-Salt Diet in the Pre- and Postweaning Periods Leads to Amygdala Oxidative Stress and Changes in Locomotion and Anxiety-Like Behaviors of Male Wistar Rats

High-Salt Diet in the Pre- and Postweaning Periods Leads to Amygdala Oxidative Stress and Changes in Locomotion and Anxiety-Like Behaviors of Male Wistar Rats

Sex differences in heart rate variability measures that predict alcohol drinking in rats

Helping behavior in prairie voles: A model of empathy and the importance of oxytocin

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