Physiologic Variations in the Cholesterol Esterifying Activity of Serum

Gherondache, Constantin N.

doi:10.1210/jcem-23-10-1024

Cited by 14 publications

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“…Thus a greater ratio of esterified cholesterol has been found in younger persons than older individuals (Gherondache, 1963;Lopez et al, 1967;Wagner & Poindexter, 1952). In the present study, there was no significant difference in percent free cholesterol between the young and old groups.…”

Section: Discussionmentioning

confidence: 98%

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Effects of exercise on free serum cholesterol.

Montgomery¹,

Ismail²

1977

Br J Sports Med

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Two age groups (young and old, n = 12) matched for physical fitness and two physical fitness groups (high and old, n = 12) matched for age participated in a four month physical fitness programme. Blood samples were drawn at four stages of metabolic stress at the pre-test and five stages at the post-test. The blood samples were analyzed by calorimetric methods for total cholesterol and free cholesterol. Statistical analysis revealed that: (1) Short-term exercise increased total cholesterol, free cholesterol, and the percent free cholesterol from the resting state to the submaximal and maximal exercise states. (2) There was no change in free serum cholesterol from the pre-to post-tests. (3) The high-fit group, compared with the low-fit group, had a lower free cholesterol level but had similar percent free cholesterol values. (4) There was no significant difference between age groups for either total serum cholesterol, free cholesterol, or the percent free cholesterol levels.

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Section: Discussionmentioning

confidence: 98%

“…Several studies have indicated that the LCAT esterifying activity decreases with age (Gherondache, 1963;Wagner & Poindexter, 1952). Thus a greater ratio of esterified cholesterol has been found in younger persons than older individuals (Gherondache, 1963;Lopez et al, 1967;Wagner & Poindexter, 1952).…”

Section: Discussionmentioning

confidence: 99%

Effects of exercise on free serum cholesterol.

Montgomery¹,

Ismail²

1977

Br J Sports Med

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“…This property has been named cholesterol-esterifying activity by Sperry (1,2), and lecithin-cholesterol acyltransferase (LCA) by Shapiro et al (3). Sperry (1) was first to report its enzymic origin, and later this was repeatedly confirmed in animals and human beings (3)(4)(5)(6)(7)(8)(9)(10). Attempts to elucidate the enzymic mechanism of the esterification of cholesterol "in vitro" were made by several investigators (11)(12)(13)(14).…”

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confidence: 99%

“…The cholesterol-esterifying activity of the serum of normal adults is expressed in milligrams of free cholesterol esterified per unit volume during incubation at 37°C for twenty-four to seventy-two hours. According to different investigators (6,8,9,14,16), it ranges from 30 to 60 per cent, or units. Experiments in animals showed a higher cholesterol-esterifying activity in sexually mature female rats than in males, with no difference in the immature animals j this suggests that estrogens enhance and androgens depress the transesterification process (17).…”

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confidence: 99%

“…In cockerels, severe experimental atherosclerosis was associated with diminished cholesterol-esterifying activity as compared to the normal condition or mild atherosclerosis (18). In humans, it was found that middle-aged subjects had lower cholesterolesterifying activity (7), and that this enzymic activity declined with advancing age (9,10). Patients with active coronary atherosclerosis had lower cholesterol-esterifying activity than did normal subjects (6,19).…”

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Serum Cholesterol and Cholesterol‐esterifying Activity in Atherosclerosis*

Gherondache¹,

Blinstrub²

1970

J American Geriatrics Society

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In a group of 240 elderly subjects (149 women and 91 men, age range 65 to 95) drawn at random from a population of 650 geriatric patients, the women showed a higher incidence of coronary artery disease and a lower incidence of cerebral atherosclerosis than the men. In the atherosclerotic patients there was a higher concentration of total serum cholesterol (213.4 ± 3.5 S.E. mg/100 ml) and a lower level of cholesterol‐esterifying activity (27.7 ± 0.8 S.E.) than in the healthy elderly subjects (180.8 ± 6.9 S.E. mg/100 ml, P < .001; and 46.8 ± 1.1 S.E., P < .001 respectively). These differences were more significant in women than in men. In general, the mean serum cholesterol level was higher in the women with atherosclerotic manifestations than in the men (223.4 ± 5.7 S.E. mg/100 ml versus 200.9 ± 2.8 S.E. mg/100 ml in the coronary artery disease group; and 220.0 ± 6.2 S.E. mg/100 ml versus 196.8 ± 7.9 S.E. mg/100 ml in the cerebral atherosclerosis group). These sex differences may be related to the hormonal changes that occur in women at the age of the menopause. The cholesterol‐esterifying activity of serum was significantly higher in the healthy group (46.8 ± 1.1 S.E.) than in the group with coronary artery disease (30.3 ± 1.2 S.E., P < .001) or in the group with cerebral atherosclerosis (25.5 ± 1.0 S.E., P <.001).

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Serum lipid transport systems: Recent advances

Lopez-S

1971

Lipids

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Lipids circulating in the plasma are transported in water soluble form as lipid‐protein complexes. Lipoproteins can be classified according to size, density, electrophoretic mobility and protein composition. The ability of low density lipoproteins and very low density lipoproteins (VLDL) to form complexes with different polyanions has been also used as a method for separation and study of serum lipoproteins. Even within classes of lipoproteins closely related otherwise, the amount of different lipids and their ratios to each other and to protein are variable. Two enzymatic systems seem to be at least partly responsible for the different lipid compositions of serum lipoproteins: lipoprotein lipase and lecithin‐cholesterol acyltransferase (LCAT). LCAT, which seems to be associated with α‐lipoproteins, is responsible for the formation of the bulk of cholesteryl‐esters in human serum. Changes in activity of this enzyme may explain the observed changes with age and disease of serum cholesteryl‐ester fatty acids (CEFA). Differences in CEFA pattern are found between newborn and adult animals, including man. The activity of serum LCAT was observed to increase with age in animals and to decrease markedly in patients with liver cirrhosis. These patients show abnormal serum CEFA patterns and abnormally low proportions of pre‐β‐ (VLDL) and α‐ (high density) lipoproteins.

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Physiologic Variations in the Cholesterol Esterifying Activity of Serum

Cited by 14 publications

References 0 publications

Effects of exercise on free serum cholesterol.

Effects of exercise on free serum cholesterol.

Serum Cholesterol and Cholesterol‐esterifying Activity in Atherosclerosis*

Serum lipid transport systems: Recent advances

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