Physiologic risk factors for early acute kidney injury in severely injured patients

Sklienka, Peter; Máca, Jan; Neiser, J; Burša, Filip; Ševčík, Pavel; Frelich, M; Petejová, Naděžda; Švagera, Zdeněk; Tomášková, Hana; Záhorec, R

doi:10.4149/bll_2020_127

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…Additionally, NGAL is significantly increased in patients with various tumor types as the NGAL gene (LCN2) is induced by tumor-promoting substances (46). Despite these limitations, our findings are consistent with previous reports that NGAL is a promising marker for the detection of AKI in severely injured patients (13,47,48). In this context, new techniques such automated machinelearning platforms have recently been proposed to facilitate its use (49).…”

Section: Discussionsupporting

confidence: 88%

Neutrophil Gelatinase-associated Lipocalin Predicts Post-traumatic Acute Kidney Injury in Severely Injured Patients

Leditzke

Wagner

Neunaber

et al. 2021

In Vivo

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Background: Early detection of acute kidney injury (AKI) is crucial in the management of multiple-organ dysfunction syndrome in severely injured patients. Standard laboratory parameters usually increase with temporal delay. Therefore, we evaluated neutrophil gelatinase-associated lipocalin (NGAL) as an early marker for acute kidney injury. Patients and Methods: We retrospectively evaluated patients admitted to a level 1 trauma center. We collected clinicodemographic data and measured kidney-related factors and plasma cytokines. Results: A total of 39 patients were included. Patients with AKI had significantly higher levels not only of serum creatinine and urea, but also of NGAL (all p<0.001) than patients without AKI. The optimal NGAL cut-off value was determined to be 177 ng/ml, showing significant correlation with imminent or manifest AKI (p<0.001). Other independent markers correlated with AKI included pre-existing chronic kidney disease, use of catecholamines, and severe injury (p<0.001). Conclusion: The serum level of NGAL is feasible early predictor of AKI.

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Section: Discussionsupporting

confidence: 88%

Neutrophil Gelatinase-associated Lipocalin Predicts Post-traumatic Acute Kidney Injury in Severely Injured Patients

Leditzke

Wagner

Neunaber

et al. 2021

In Vivo

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“…Several small studies have attempted to predict post-traumatic AKI by scoring clinical parameters and specifying the cut-off values for biomarkers. [18][19][20] Unfortunately, these studies are not generalizable, as they are limited to the injury site or use biomarkers that are not measured in routine examinations.…”

Section: Discussionmentioning

confidence: 99%

Prediction of early acute kidney injury after trauma using prehospital systolic blood pressure and lactate levels: A prospective validation study

Nasu

Ueda

Kawashima

et al. 2022

Injury

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Physiologic risk factors for early acute kidney injury in severely injured patients

Cited by 2 publications

References 36 publications

Neutrophil Gelatinase-associated Lipocalin Predicts Post-traumatic Acute Kidney Injury in Severely Injured Patients

Neutrophil Gelatinase-associated Lipocalin Predicts Post-traumatic Acute Kidney Injury in Severely Injured Patients

Prediction of early acute kidney injury after trauma using prehospital systolic blood pressure and lactate levels: A prospective validation study

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