Physiologic Failure: Multiple Organ Dysfunction Syndrome

Buchman, Timothy G.

doi:10.1007/978-0-387-33532-2_27

Cited by 13 publications

(17 citation statements)

References 27 publications

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“…Although our study is limited to a data-driven approach the empirical findings may facilitate future efforts on developing and testing network models of physiologic interactions. In relation to critical clinical care, where multiple organ failure is often the reason for fatal outcome [1,2], our framework may have practical utility in assessing whether dynamical links between physiological systems remain substantially altered even when the function of specific systems is restored after treatment [3]. While we demonstrate one specific application, the framework we developed can be applied to a broad range of complex systems where the TDS method can serve as a tool to characterize and understand the dynamics and function of real-world heterogeneous and interdependent networks.…”

Section: Discussionmentioning

confidence: 99%

“…A further challenge to the contemporary theoretical framework of complex networks is posed by real-world systems where each network node represents a multicomponent complex system, a network on its own, with its own topology and regulatory mechanism that can vary in time, and where the transient output dynamics of individual networks affect the entire "network of networks" by reinforcing (or weakening) the coupling between individual networks and changing network topology. A prime example of a network of networks is the human organism, where integrated physiologic systems, each representing a complex network, form a network of interactions that in turn affect physiologic function of individual systems or of the entire organism, and where breakdown in the interaction between physiological systems under certain conditions may lead to a cascade of system failures [1,2].…”

Section: Complex Network Approach To Physiologic Interactionsmentioning

confidence: 99%

“…Multiple organ failure is often the reason for fatal outcome in critical clinical care [1,2]. In fact, multiple organ dysfunction remains a leading cause of death in most intensive care units.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Network Physiology: Mapping Interactions Between Networks of Physiologic Networks

Ivanov

Bartsch

2014

Understanding Complex Systems

102

110

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The human organism is an integrated network of interconnected and interacting organ systems, each representing a separate regulatory network. The behavior of one physiological system (network) may affect the dynamics of all other systems in the network of physiologic networks. Due to these interactions, failure of one system can trigger a cascade of failures throughout the entire network. We introduce a systematic method to identify a network of interactions between diverse physiologic organ systems, to quantify the hierarchical structure and dynamics of this network, and to track its evolution under different physiologic states. We find a robust relation between network structure and physiologic states: every state is characterized by specific network topology, node connectivity and links strength. Further, we find that transitions from one physiologic state to another trigger a markedly fast reorganization in the network of physiologic interactions on time scales of just a few minutes, indicating high network flexibility in response to perturbations. This reorganization in network topology occurs simultaneously and globally in the entire network as well as at the level of individual physiological systems, while preserving a hierarchical order in the strength of network links. Our findings highlight the need of an integrated network approach to understand physiologic function, since the framework we develop provides new information which can not be obtained by studying individual systems. The proposed system-wide integrative approach may facilitate the development of a new field, Network Physiology.

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Section: Discussionmentioning

confidence: 99%

Section: Complex Network Approach To Physiologic Interactionsmentioning

confidence: 99%

See 1 more Smart Citation

Network Physiology: Mapping Interactions Between Networks of Physiologic Networks

Ivanov

Bartsch

2014

Understanding Complex Systems

102

110

View full text Add to dashboard Cite

show abstract

“…In medicine such failure cascades may be manifest as multiple organ dysfunction syndrome (MODS) that rapidly accumulates following a minor insult; MODS is the leading cause of death in intensive care units. As Buchman [108] points out:…”

Section: Summary Conclusion and Speculationsmentioning

confidence: 99%

“…One of the consequences of the traditional view of disease is what Buchman [108] calls ''fix-the-number'' imperative:…”

Section: Summary Conclusion and Speculationsmentioning

confidence: 99%