Physiologic exercise-induced lymphocytosis

Martina, Benedict; Schreck, M.; Droste, Conrad; Roskamm, H.; Thewis, André; Speck, B

doi:10.1007/bf01728796

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…Alternatively, exercise preconditioning may elicit a sustainable protective effect by altering immune function through the activation of the sympathetic nervous system ( Bellinger et al., 2008 ). In response to elevated levels of catecholamines, acute stressors such as exercise produce a profound, albeit transient, lymphocytosis ( Martina et al., 1990 ). Mobilization of T lymphocytes from their sites of lymphopoiesis, traversing the blood stream, with subsequent trafficking into and egress from secondary lymphoid organs is well defined and utilizes a range of ligands and receptors ( Springer, 1994 ; von Andrian and Mackay, 2000 ).…”

Section: Discussionmentioning

confidence: 99%

Forced Exercise Preconditioning Attenuates Experimental Autoimmune Neuritis by Altering T_h1 Lymphocyte Composition and Egress

et al. 2015

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A short-term exposure to moderately intense physical exercise affords a novel measure of protection against autoimmune-mediated peripheral nerve injury. Here, we investigated the mechanism by which forced exercise attenuates the development and progression of experimental autoimmune neuritis (EAN), an established animal model of Guillain–Barré syndrome. Adult male Lewis rats remained sedentary (control) or were preconditioned with forced exercise (1.2 km/day × 3 weeks) prior to P2-antigen induction of EAN. Sedentary rats developed a monophasic course of EAN beginning on postimmunization day 12.3 ± 0.2 and reaching peak severity on day 17.0 ± 0.3 (N = 12). By comparison, forced-exercise preconditioned rats exhibited a similar monophasic course but with significant (p < .05) reduction of disease severity. Analysis of popliteal lymph nodes revealed a protective effect of exercise preconditioning on leukocyte composition and egress. Compared with sedentary controls, forced exercise preconditioning promoted a sustained twofold retention of P2-antigen responsive leukocytes. The percentage distribution of pro-inflammatory (Th1) lymphocytes retained in the nodes from sedentary EAN rats (5.1 ± 0.9%) was significantly greater than that present in nodes from forced-exercise preconditioned EAN rats (2.9 ± 0.6%) or from adjuvant controls (2.0 ± 0.3%). In contrast, the percentage of anti-inflammatory (Th2) lymphocytes (7–10%) and that of cytotoxic T lymphocytes (∼20%) remained unaltered by forced exercise preconditioning. These data do not support an exercise-inducible shift in Th1:Th2 cell bias. Rather, preconditioning with forced exercise elicits a sustained attenuation of EAN severity, in part, by altering the composition and egress of autoreactive proinflammatory (Th1) lymphocytes from draining lymph nodes.

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Section: Discussionmentioning

confidence: 99%

Forced Exercise Preconditioning Attenuates Experimental Autoimmune Neuritis by Altering T_h1 Lymphocyte Composition and Egress

et al. 2015

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Reactive and Non‐neoplastic Phenomena

Leach

Drummond

Doig

2013

Practical Flow Cytometry in Haematology Diagnosis

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Effects of mental arithmetic stress on blood cell counts and the immune system

Kondo

Morimoto

1996

Environ Health Prev Med

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To determine whether acute mental stress alters the composition of peripheral blood cells or components of the immune system, we determined blood cell counts and leukocyte differential counts, and examined lymphocyte subsets, before, during, and after 10 min. of mental arithmetic in 20 healthy female students. During mental stress the absolute number of leukocytes, lymphocytes, CD8+ cells, and CD16+ cells increased significantly, and the rate of CD8+ cell increase was higher than CD4+ cell increase. Therefore the CD4+/CD8+ ratio decreased significantly during mental stress. Erythrocyte counts, hemoglobin concentrations and packed cell volumes remained unchanged during and after mental stress. These results demonstrate that acute mental stress is associated mainly with rapid peripheral blood lymphocyte changes, including the release of CD8+ and CD 16+ cells into circulation. The absence of significant increases in erythrocyte counts, hemoglobin concentrations, and packed cell volumes during stress indicates that changes in lymphocyte composition cannot be explained by the hemoconcentration. Thus, acute mental stress has a detectable influence on peripheral blood cell counts and the immune system.

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Physiologic exercise-induced lymphocytosis

Cited by 3 publications

References 3 publications

Forced Exercise Preconditioning Attenuates Experimental Autoimmune Neuritis by Altering T_h1 Lymphocyte Composition and Egress

Forced Exercise Preconditioning Attenuates Experimental Autoimmune Neuritis by Altering T_h1 Lymphocyte Composition and Egress

Reactive and Non‐neoplastic Phenomena

Effects of mental arithmetic stress on blood cell counts and the immune system

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Physiologic exercise-induced lymphocytosis

Cited by 3 publications

References 3 publications

Forced Exercise Preconditioning Attenuates Experimental Autoimmune Neuritis by Altering Th1 Lymphocyte Composition and Egress

Forced Exercise Preconditioning Attenuates Experimental Autoimmune Neuritis by Altering Th1 Lymphocyte Composition and Egress

Reactive and Non‐neoplastic Phenomena

Effects of mental arithmetic stress on blood cell counts and the immune system

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Product

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Forced Exercise Preconditioning Attenuates Experimental Autoimmune Neuritis by Altering T_h1 Lymphocyte Composition and Egress

Forced Exercise Preconditioning Attenuates Experimental Autoimmune Neuritis by Altering T_h1 Lymphocyte Composition and Egress