Physiologic Effects of Hyperbaric Oxygen on Oxygen Transport and Tissue Oxygen Pressure

Ratzenhofer-Komenda, B; Favory, Raphaël; W, Welslau; Smolle‐Jüttner, Freyja Maria; Mathieu, Daniel

doi:10.1007/1-4020-4448-8_5

Cited by 4 publications

(1 citation statement)

References 54 publications

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“…When breathing normobaric air, arterial oxygen tension is approximately 100 mmHg, and tissue oxygen tension approximately 55 mmHg. However, 100% oxygen at 3 ATA can increase arterial oxygen tensions to 2,000 mmHg, and tissue oxygen tensions to around 500 mmHg (Ratzenhofer-Komenda et al, 2006). The marked increased oxygen tension gradient from the blood to metabolizing cells is a key mechanism by which hyperoxygenation of arterial blood can improve effective cellular oxygenation even at low rates of tissue blood flow (Thom, 2011).…”

Section: Hbot Increases Tissue Oxygenationmentioning

confidence: 99%

Hyperbaric oxygen therapy for traumatic brain injury: bench-to-bedside

Manaenko

et al. 2016

Med Gas Res

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Traumatic brain injury (TBI) is a serious public health problem in the United States. Survivors of TBI are often left with significant cognitive, behavioral, and communicative disabilities. So far there is no effective treatment/intervention in the daily clinical practice for TBI patients. The protective effects of hyperbaric oxygen therapy (HBOT) have been proved in stroke; however, its efficiency in TBI remains controversial. In this review, we will summarize the results of HBOT in experimental and clinical TBI, elaborate the mechanisms, and bring out our current understanding and opinions for future studies.

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Section: Hbot Increases Tissue Oxygenationmentioning

confidence: 99%

Hyperbaric oxygen therapy for traumatic brain injury: bench-to-bedside

Manaenko

et al. 2016

Med Gas Res

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Emerging indications for hyperbaric oxygen

Bennett

Mitchell

2019

Current Opinion in Anaesthesiology

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Purpose of review To identify and discuss emerging trends in the therapeutic use of hyperbaric oxygen. Recent findings There has been a maturing of the clinical evidence to support the treatment of sudden hearing loss, a wide range of problematic chronic wound states and the prevention and treatment of end-organ damage associated with diabetes mellitus. On the other hand, the controversy continues concerning the use of hyperbaric oxygen therapy (HBOT) to treat sequelae of mild traumatic brain injury. HBOT remains poorly understood by many medical practitioners despite more than 50 years of clinical practice. Pharmacological actions arise from increased pressures of oxygen in the blood and tissues. Most therapeutic mechanisms identified are not the simple result of the reoxygenation of hypoxic tissue, but specific effects on immunological and metabolic pathways by this highly reactive element. HBOT remains controversial despite biological plausibility and a solid clinical evidence base in several disease states. Summary Multiple proposals for new indications for HBOT continue to emerge. Although many of these will likely prove of limited clinical importance, some show significant promise. Responsible practitioners remain acutely aware of the need for high-quality clinical evidence before introducing emerging indications into routine practice.

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