1956
DOI: 10.1016/0002-9343(56)90152-8
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Physiologic considerations in the genesis and management of nodular goiter

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Cited by 25 publications
(8 citation statements)
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“…The fact that our patients were a surgical series with relatively Large goitres and a predominance of multinodular forms of long duration may well explain the discrepancy in frequency. That goitrous tissue may show increasing autonomous behaviour is supported by autoradiographic studies (18), and scintigraphic findings demonstrating subnormal suppressibility of the goitrous gland by T3 (3, 10, 12). From two of these studies (3, 12) it also appears that autonomously functioning tissue may not be confined to nodules, but may show a variable internodular distribution as well.…”
Section: Discussionmentioning
confidence: 84%
“…The fact that our patients were a surgical series with relatively Large goitres and a predominance of multinodular forms of long duration may well explain the discrepancy in frequency. That goitrous tissue may show increasing autonomous behaviour is supported by autoradiographic studies (18), and scintigraphic findings demonstrating subnormal suppressibility of the goitrous gland by T3 (3, 10, 12). From two of these studies (3, 12) it also appears that autonomously functioning tissue may not be confined to nodules, but may show a variable internodular distribution as well.…”
Section: Discussionmentioning
confidence: 84%
“…Characteristically, in this latter group, the goitrous tissue on the scintigram reveals a patchy uptake with areas showing varying predominance of nonfunctioning nodules (Gemsenjager et al, 1976). Based on autoradiographic and in vivo scintigraphic studies it appears that autonomously functioning tissue may not only be confined t o visible nodules (pattern 1 and 2 ; Miller & Block, 1970), but may also show a variable internodular distribution (pattern 3 and 4; Miller & Block, 1970;Taylor, 1956;Dige-Petersen et al, 1976). Accordingly, differences in scintigraphic appearance in euthyroid goitrous patients showing TRH refractoriness seem to be explained by the variability in relative distribution of autonomous tissue in nodular and internodular compartments.…”
Section: Discussionmentioning
confidence: 97%
“…It is considered that in later stages of the natural history of goitre evolution, increasing autonomous behaviour of goitrous tissue appears. Autoradiographic studies of goitrous tissue (Taylor, 1956) and scintigraphic findings demonstrating subnormal suppressibility of the goitrous gland by T3 lend further support to this view (Miller & Block, 1970;Dige-Petersen et al, 1976).…”
mentioning
confidence: 85%
“…Resorption of colloid or follicular necrosis causes a reduction in the blood supply, eventually resulting in fibrosis and degeneration of the nodule. In this setting, levothyroxine suppressive therapy will not influence the pathologic processes within the nodule [26,27]. A number of other factors, including epidermal growth factor [28], insulin-like growth factor [29] and thyroid stimulating immunoglobulins [29], have been suggested to induce the growth of thyroid nodules.…”
Section: Discussionmentioning
confidence: 99%