Physiologic changes in vascular birthmarks during early infancy: Mechanisms and clinical implications

Harlequin colour change: unilateral erythema in a newborn

“…The differential diagnosis includes port-wine stain and nascent hemangioma of infancy. 3 The transient nature of harlequin colour change helps to differentiate it from these other conditions.…”

A Different Harlequin Color Change Case

“…Probable differential diagnosis are Port-wine stain and nascent hemangioma of infancy, but these can be differentiated due to transient nature of this condition. 15 While it is stated in the literature that this condition occurs usually in premature, newborn infants exposed to hypoxia, our patient was born on time and not exposed to hypoxia. 3,4 While it is stated in some sources that it is seen as high as about 10% of newborns, it is mentioned as a "rare" case in some of them.…”

“…. 5,6 It is stated that this case may occur in newborns with prostaglandin E1 applied congenital cyanotic heart disease. However, it is also stated that this case may have occurred as associated with hypoxia that is another possible launcher of it and may have been linked inadvertently to prostaglandin E1 application.…”

“…3,4 While it is stated in some sources that it is seen as high as about 10% of newborns, it is mentioned as a "rare" case in some of them. 5,6 Since parents are usually on alarm, it is important to recognize this condition of newborn and point out that it is a temporary situation without leaving sequellae. …”

Hemangiomas - current therapeutic strategies

“…Other complications include pain, infection, ulceration, and bleeding (Blei, 2005;Cordoro et al, 2009), the latter of which, although rare, can lead to severe anaemia (Blei, 2005). In patients with large hemangiomas, moderate thrombocytopenia is a common occurrence (Martins 1970).…”