Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp oronary bifurcation lesions are one of the most challenging lesion subsets and known to have a lower angiographic success rate and a higher risk of procedural complications with a greater restenosis rate than non-bifurcation lesions. 1-3 Therefore, coronary bifurcation lesions have been the subject of many studies; however, realworld practice patterns and long-term clinical outcomes have not been adequately addressed by previous studies. Most previous studies focused on either treatment strategies or techniques and were of a small to medium sample size with a follow-up period of 6-12 months in a randomized setting. 1,4,5 Although a few of these previous studies used real-world data sets, these studies were not based on registries dedicated to bifurcation lesions and had only a medium sample size that was inadequate to identify prognostic factors by multivariate analysis. 6,7 Therefore, we investigated long-term clinical results and predictors of adverse outcomes after percutaneous coronary intervention (PCI) with drug-eluting stents (DES) for coronary bifurcation lesions using data from a dedicated, large, multicenter real-world registry.