Physiologic and metabolic results of pancreatic cold storage with Histidine-Tryptophan-Ketoglutarate-HTK solution (Custodiol) � in the porcine autotransplantation model

Troisi, Roberto; Meester, D.; Regaert, Bart; Jacobs, Bart; Broucke, Caroline; Cuvelier, Claude; Hemptinne, Bernard de; Hesse, Uwe

doi:10.1007/s001470050669

Transplant International

2000

DOI: 10.1007/s001470050669

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Physiologic and metabolic results of pancreatic cold storage with Histidine-Tryptophan-Ketoglutarate-HTK solution (Custodiol) � in the porcine autotransplantation model

Roberto Troisi¹,

D. Meester²,

Bart Regaert³

et al.

Abstract: HTK-solution is suitable for 24 h pancreatic preservation in vivo; the perfusion requires at least 4 min for electrolyte equilibration. Long preservation time (48 h) resulted in a transitory DEGF.

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Cited by 2 publications

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Technical and Immunosuppressive Advances in Transplantation forInsulin‐Dependent Diabetes Mellitus

Odorico

Sollinger

2002

World j. surg.

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Pancreas transplantation has emerged as the single most effective way to achieve normal glucose homeostasis inpatients with type I insulin-dependent diabetes mellitus. Optimal immunosuppressive strategies for pancreas transplantation continue to evolve with the use of newer, more potent immunosuppressive agents,particularly tacrolimus, mycophenolate mofetil, and rapamycin. These agents have contributed to substantially lower rates of allograft rejection and improved graft survival. Regimens designed to avoid nephrotoxicity or spare corticosteroid therapy are emerging as the variety of drug options grows. Also contributing to progressively better results for solitary pancreas transplants are reductions in early graft loss rates and the development of safe, effective biopsy techniques, permitting accurate diagnosis of rejection. Collectively,these factors have allowed solitary pancreas allograft recipients, a group of patients with historically poor long-term graft survival, to enjoy successes nearly equivalent to those of combined kidney-pancreas transplants. Consequently, the American Diabetes Association strongly endorses pancreas transplantation in diabetic patients who have received prior kidney transplants and who have life-threatening metabolic lability.

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Technical and Immunosuppressive Advances in Transplantation forInsulin‐Dependent Diabetes Mellitus

Odorico

Sollinger

2002

World j. surg.

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History of transplantation at the University Hospital of Ghent Belgium 1965-2002

Hesse

Hemptinne

Derom

2003

Acta Chirurgica Belgica

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Physiologic and metabolic results of pancreatic cold storage with Histidine-Tryptophan-Ketoglutarate-HTK solution (Custodiol) � in the porcine autotransplantation model

Abstract: HTK-solution is suitable for 24 h pancreatic preservation in vivo; the perfusion requires at least 4 min for electrolyte equilibration. Long preservation time (48 h) resulted in a transitory DEGF.

Cited by 2 publications

References 21 publications

Technical and Immunosuppressive Advances in Transplantation forInsulin‐Dependent Diabetes Mellitus

Technical and Immunosuppressive Advances in Transplantation forInsulin‐Dependent Diabetes Mellitus

History of transplantation at the University Hospital of Ghent Belgium 1965-2002

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