Physiochemical Stability of Intravenous Fat Emulsion in Combination with Medications Used for Resuscitation

Cocchio, Craig; Geib, Ann-Jeannette; Rynn, Kevin O.

doi:10.15226/2374-6866/1/1/00105

Cited by 1 publication

(1 citation statement)

References 9 publications

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“…The results showed that all formulas were unstable between 8 and 24 hrs, and each admixture showed increment of lipid globules and contained lipid globules which sized 5 µm. The research by Cocchio et al [18] was done by admixing IV lipid emulsion with IV medications through Y-site in ratio 1:1 and the results of PFAT5 (proportion of enlarged droplets >5 µm) were significantly higher.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Sodium Chloride 0.9% Infusion Solution and Ringer’s Solution on Particle Size of Intravenous Lipid Emulsion (Intralipid 20%)

Bangun

Nil²,

Arianto³

2016

Asian J Pharm Clin Res

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Objective: To study the effect of admixing intralipid (IL) with sodium chloride (NaCl) 0.9% infusion solution or Ringer's solution (RS) on physical stability of IL.Methods: Incompatibility test was done in two methods of admixture, i.e. in one container (1:1) and through three-way stopcock (1:2). They were observed for 24 hrs on its emulsion type, pH, microscopic observation of lipid globules, and globules size. Results:The results of admixing IL and electrolyte solution (NaCl or RS) in one container and through three-way stopcock showed no changes in color and emulsion type (O/W). Physical stability evaluation results of IL and NaCl admixture in one container and through three-way stopcock showed that the pH value was 5.1 and 5.2, respectively, and microscopic observation of lipid globules and its size showed coalescence on 24 hrs with size 625.16 nm (one container) and stable during 24 hrs (three-way stopcock). Physical stability evaluation results of IL and RS admixture in one container and through three-way stopcock showed that the pH value was 4.9 and 5.1, respectively, and microscopic observation of lipid globules and its size showed coalescence on 12 hrs with size 572.81 nm (one container) and flocculation on 24 hrs with size 558.12 nm (three-way stopcock). Conclusion:Admixing electrolyte solution (NaCl or RS) and IL in one container and through three-way stopcock causes the larger globule size of IL.

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Section: Introductionmentioning

confidence: 99%