Physiochemical investigation of the excipients mixed micelles for improvement of encapsulation and controlled release of antihistamine drugs

Kumar, Mukul; Elahi, Daniyal; Bhardwaj, Anshika; Sharma, Simran; Khushi, Kavya; Singh, Ekta; Singh, Nandini; Srivastava, Anirudh

doi:10.1016/j.molliq.2022.119971

Cited by 15 publications

(5 citation statements)

References 57 publications

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“…[11][12][13] The interactions of drug-micelles with biological membrane systems provide a better understanding of more complicated biological processes like the delivery of medicinal agents via cell membranes. [14][15][16] The interaction of drugs with biological tissues is an important and fundamental process because the mechanism of drug actions is associated with their binding to biological systems. 17 To understand the mechanism of drug-membrane interactions, it is pertinent to perform a comparative analysis of the drug interaction with cationic, zwitter ionic, anionic, and neutral surfactants.…”

Section: Introductionmentioning

confidence: 99%

“…All these characteristic properties of micellar systems make them a suitable candidate for drug delivery applications 11–13 . The interactions of drug‐micelles with biological membrane systems provide a better understanding of more complicated biological processes like the delivery of medicinal agents via cell membranes 14–16 . The interaction of drugs with biological tissues is an important and fundamental process because the mechanism of drug actions is associated with their binding to biological systems 17 …”

Section: Introductionmentioning

confidence: 99%

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Molecular interaction of nonsteroidal anti‐inflammatory prodrug nepafenac with ionic surfactants

Abbas,

Shafqat,

Nazar

et al. 2024

Int J of Chemical Kinetics

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Drug‐surfactant interaction increases the solubility of poorly water‐soluble drugs and design better pharmaceutical formulations. The degree of interaction of nepafenac (NP), a nonsteroidal anti‐inflammatory prodrug was studied with ionic surfactant molecules such as cationic surfactant cetrytrimethyl ammonium bromide (CTAB) and anionic surfactant sodium dodecyl sulphate (SDS) in an aqueous medium at room temperature. NP made mixed micelles with CTAB and SDS. To investigate the influence of interactions, conductivity measurements, UV–visible spectroscopy, and fluorescence measurements were recorded. The quantification of NP–surfactant interactions was investigated using various mathematical models. The CMC values determined from conductivity measurements of pure surfactants were 0.96 mM for CTAB and 8.14 mM for SDS near to their literature values. At different mole fractions of NP in UV measurements, binding constants from lnKb were found 0.025 and 0.123 and number of NP molecules per micelles (n) 67, 46 for CTAB and SDS, respectively. The mixed micelles of NP–CTAB and NP–SDS revealed that CTAB has a strong interaction with NP than SDS. The Benesi–Hildebrand relationship, Stern–Volmer and Kawamura replica for the partition coefficient were used to confirm the findings. We are confident that the host–guest interaction mechanism can contribute to a better understanding of molecular recognition in the phospholipid membrane model.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Molecular interaction of nonsteroidal anti‐inflammatory prodrug nepafenac with ionic surfactants

Abbas,

Shafqat,

Nazar

et al. 2024

Int J of Chemical Kinetics

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“…In biology, it appears to be helpful in isolating DNA from inside the cell as well as for analysing proteins [2,3]. CTAB-based mixed micelles are useful in the delivery of antihistamine drugs [4]. Moreover, it is employed as a reagent for obtaining gold nanoparticles, which are used in medicine and other areas, e.g., optics, electronics or catalysis [5].…”

Section: Introductionmentioning

confidence: 99%

“…CTAB's reactivity is largely the result of the positive charge of its ions in solution. Cetyltrimethylammonium cation forms micellar ionic associates with anionic surfactants and anionic dyes [4,8]. Ionic associates of CTAB with hyaluronic acid anions form nanogels [9].…”

Section: Introductionmentioning

confidence: 99%

Coagulation of Hydrophobic Ionic Associates of Cetyltrimethylammonium Bromide and Carrageenan

Shyichuk,

Ziółkowska,

Szulc

2023

Molecules

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In aqueous solutions, cetyltrimethylammonium cations bind to carrageenan polyanions, and the resulting ionic associates form macroscopic aggregates due to hydrophobic interaction. At certain ratios of cetyltrimethylammonium to carrageenan, the resulting colloidal particles auto-flocculate. According to visual observations, the ratio ranges from 1 to 3 mmol/g; otherwise the suspensions are stable. By measuring the sedimentation rate and particle size distribution, the most extensive flocculation was found to be from 1.7 to 2.3 mmol/g. The ratio corresponding to the fastest auto-flocculation was precisely determined by titrating the reagents with small increments and recording the turbidity. The turbidimetric titration plots contain distinct break points corresponding to the most extensive flocculation. These break points occur at the same ratio of carrageenan to cetyltrimethylammonium over a wide range of reagent concentrations. The precise values of the critical ratio were found to be 1.78 and 1.53 mmol/g, respectively, during the titration of cetyltrimethylammonium with carrageenan and vice versa. The number of anionic sulfate groups in carrageenan was measured by ICP OES and found to be 1.35 mmol/g. This value is consistent with the critical ratio of the auto-flocculation.

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“…2,3 Surfactants have applications in a wide variety of areas of chemistry. These amphiphilic molecules have been used in nanotechnology, 4,5 pharmaceutical formulations, [6][7][8] detergents, 9,10 corrosion inhibitors, [11][12][13] emulsifier systems, 14,15 and petroleum industry. 16 In addition to this wide area of use, surfactants have had a wide variety of applications in the field of electrochemistry from past to present.…”

Section: Introductionmentioning

confidence: 99%

Surfactant-based Sensors in Chemical and Biochemical Detection

2023

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Describing the importance of surfactants in electrochemical investigations related to biologically and environmentally vital chemicals, this book charts the progression of highly responsive electrochemical sensors using surfactants as a modifying agent in the sensor field. It provides contributed chapters from respected researchers on information concerning the activity of target molecules and electron transfer kinetics arising at the surface of the fabricated sensor materials. Surfactant-based electrochemical sensors are of great interest in the quest to find low-cost, fast and highly responsive sensing devices and one aim of this book is to help improve the competence and knowledge in this newly emerging interdisciplinary research area. Attracting an audience of students, academics, industrialists and engineers, it will interest researchers seeking to use non-toxic sensors in their detection challenges.

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Physiochemical investigation of the excipients mixed micelles for improvement of encapsulation and controlled release of antihistamine drugs

Cited by 15 publications

References 57 publications

Molecular interaction of nonsteroidal anti‐inflammatory prodrug nepafenac with ionic surfactants

Molecular interaction of nonsteroidal anti‐inflammatory prodrug nepafenac with ionic surfactants

Coagulation of Hydrophobic Ionic Associates of Cetyltrimethylammonium Bromide and Carrageenan

Surfactant-based Sensors in Chemical and Biochemical Detection

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