“…Currently, fs-lasers have been widely used for precision machining and modi cation of various materials such as polymers 12 , glasses 13 , semiconductors 14 and metals 15 . In bio-medical eld, fs-lasers have been used in a variety of researches 16 , such as stomatology 17 , urology 18 , otolaryngology 19 and orthopedics 20 , which demonstrated minimal collateral damage of fs-laser to biological tissues, revealing its potential as a surgical tool. However, despite the reported utilization of femtosecond lasers in scenarios that do not demand meticulous control, such as photodynamic therapy (PDT) [21][22][23] , drug delivery enhancement 24 , and skin suturing assistance 25 , their application as a highly precise surgical tool in dermatology and plastic surgery remains unattained.…”