Physiochemical and biological properties of phosphorylated polysaccharides from Dictyophora indusiata

Deng, Chao; Fu, Haitian; Xu, Jingjing; Shang, Jingying; Cheng, Yongmei

doi:10.1016/j.ijbiomac.2014.09.053

Cited by 72 publications

(45 citation statements)

References 33 publications

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“…21,28 In the present research, the polysaccharide chains of pAPS and sAPS were not degraded during the modifications. pAPS exhibits adsorption peaks related to P ¼ O stretching vibration, 23 P-OH and P-O-C bonds. 13 Asymmetrical S ¼ O stretching vibration and symmetrical C-O-S vibration have been detected in sAPS 3 ( Figure 2).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the anti-duck hepatitis A virus activities of phosphorylated and sulfated Astragalus polysaccharides

Wang

Chen

Yang

et al. 2016

Exp Biol Med (Maywood)

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Duck hepatitis A virus (DHAV) (Picornaviridae) causes an infectious disease in ducks which results in severe losses in duck industry. However, the proper antiviral supportive drugs for this disease have not been discovered. Polysaccharide is the main ingredient of Astragalus that has been demonstrated to directly and indirectly inhibit RNA of viruses replication. In this study, the antiviral activities of Astragalus polysaccharide (APS) and its derivatives against DHAV were evaluated and compared. APS was modified via the sodium trimetaphosphate and sodium tripolyphosphate (STMP-STPP) method and chlorosulfonic acid-pyridine method to obtain its phosphate (pAPS) and sulfate (sAPS), respectively. The infrared structures of APS, pAPS, and sAPS were analyzed with the potassium bromide disc method. Additionally, the antiviral activities were evaluated with the MTT ((4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide) method in vitro and the artificial inoculation method in vivo. The clinical therapy effects were evaluated by mortality rate, liver function-related biochemical indicators, and visual changes in pathological anatomy. The anti-DHAV proliferation effects of APS, pAPS, and sAPS on the viral multiplication process in cell and blood were observed with the reverse transcription-polymerase chain reaction method. The results revealed that pAPS inhibited DHAV proliferation more efficiently in the entire process of viral multiplication than APS and sAPS. Moreover, only pAPS significantly improved the survival rate to 33.5% and reduced the DHAV particle titer in the blood as well as liver lesions in clinical trials. The results indicated that pAPS exhibited greater anti-DHAV activity than APS and sAPS both in vitro and in vivo.

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Section: Discussionmentioning

confidence: 99%

Comparison of the anti-duck hepatitis A virus activities of phosphorylated and sulfated Astragalus polysaccharides

Wang

Chen

Yang

et al. 2016

Exp Biol Med (Maywood)

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“…Ye and others () reported that phosphorylation is an effective way of improving the antitumor activity of exopolysaccharide from Lachnum (LEP‐1a). Furthermore, compared with the natural polysaccharides in Dictyophora indusiata , its phosphorylated derivatives showed more significant inhibitory effects on the growth of MCF‐7 and B16 tumor cells because of the enhanced water solubility (Dengand others ).…”

Section: Influence Of Molecular Modification On Bioactivities Of Polymentioning

confidence: 99%

Molecular Modification of Polysaccharides and Resulting Bioactivities

Xiong

Lai

et al. 2015

Comp Rev Food Sci Food Safe

394

172

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Polysaccharides are ideal natural resources for supplements and pharmaceuticals that have received more and more attention over the years. Natural polysaccharides have been shown to have fewer side effects, but because of their inherently physicochemical properties, their bioactivities were difficult to compare with those of synthetic drugs. Thus, researchers have modified the structures and properties of natural polysaccharides based on structure-activity relationships and have obtained better functionally improved polysaccharides. This review focuses on the major modification methods of polysaccharides, and discusses the effect of molecular modification on their physicochemical properties and bioactivities. Molecular modification methods mainly include chemical, physical, and biological changes. Chemical modification is the most widely used method; it can significantly increase the water solubility and bioactivities of polysaccharides by grafting onto other groups. Physical and biological modifications only change the molecular weight of a polysaccharide, and thereby change its physicochemical properties and bioactivities. Most of the molecular modifications bring about an increase in the antioxidant activity of polysaccharides, and among these, sulfated and acetylated modifications are very common. Furthermore, phosphorylation modification is the most common application to increase antitumor activity, and modified polysaccharides have been shown to have anti-HIV activity as the result of sulfated modification.

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“…Further variations of the water or sodium carbonate polysaccharide extracts include a (1→3)-α-D-mannan, branched (1→3)-β-D-glucan and the location of the O-acetylation of the (1→3)-α-D-mannan [8][9][10][11][12]. Phosphorylated polysaccharides could also be obtained from the mushroom as shown by Deng et al [13] in their work on the physicochemical characterization of polysaccharides obtained from a water-insoluble crude polysaccharides. Another interesting structural feature of the polysaccharides is the triple helical chain conformation of some in water.…”

Section: Polysaccharidesmentioning

confidence: 99%

“…Comparative study-phosphorylated derivative more potent than native polysaccharides. Deng et al [13] Water-soluble sulfated polysaccharides-prepared from water insoluble polysaccharides OH . and DPPH radical scavenging assay; cytotoxicity against MCF-7 and B16 cells…”

Section: Preparation Experimental Model Key Findings Referencesmentioning

confidence: 99%

“…In addition to similar radical scavenging effects, the reducing power of purified water soluble β-d-glucan polysaccharide was further shown [21]. In an attempt to improve the biological activities of the water-insoluble polysaccharides, the sulfated [43] and phosphorylated [13] derivatives have been prepared. In both cases, improvement in the antioxidant activity was observed for the derivatives along with improved water solubility.…”

Section: Antioxidant Effectmentioning

confidence: 99%

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The Chemistry, Pharmacology and Therapeutic Potential of the Edible Mushroom Dictyophora indusiata (Vent ex. Pers.) Fischer (Synn. Phallus indusiatus)

Habtemariam

2019

Biomedicines

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Dictyophora indusiata (Vent. Ex. Pers.) Fischer or Phallus indusiatus is an edible member of the higher mushroom phylum of Basidiomycetes. Known for its morphological elegance that gave it the names bridal veil fungus, veiled lady or queen of the mushrooms, it has numerous medicinal values that are beginning to be acknowledged through pharmacological efficacy studies. In an attempt to promote research on this valuable natural resource, the present communication aims to provide a comprehensive review of the chemistry, pharmacology and potential therapeutic applications of extracts and compounds isolated from D. indusiata. Of the bioactive compounds, the chemistry of the polysaccharides as major bioactive components primarily the β-(1→3)-D-glucan with side branches of β-(1→6)-glucosyl units are discussed, while small molecular weight compounds include terpenoids and alkaloids. Biochemical and cellular mechanisms of action from general antioxidant and anti-inflammatory to more specific signaling mechanisms are outlined along with potential applications in cancer and immunotherapy, neurodegenerative and chronic inflammatory diseases, etc. Further research areas and limitations of the current scientific data are also highlighted.Biomedicines 2019, 7, 98 2 of 21 have been reported [3]. The composition of carbohydrates can reach up to 47% of the dry weight of which the soluble polysaccharides are about 38%, while crude fibres and crude proteins contents are about 29% and 6% respectively [1]. In this communication, the emphasis is on the compositions of the fruiting body far beyond nutritional source with a focus on their pharmacologically active components and their therapeutic implications. In this connection, considerable attention has been given to the major components of the fungus, the polysaccharides, while small molecular weight drug-like molecules such as terpenoids and alkaloids have not been extensively studied. The chemistry and biological significance of all the bioactive compounds known from D. indusiata are herein scrutinised.Biomedicines 2020, 8, x FOR PEER REVIEW 2 of 21 have been reported [3]. The composition of carbohydrates can reach up to 47% of the dry weight of which the soluble polysaccharides are about 38%, while crude fibres and crude proteins contents are about 29% and 6% respectively [1]. In this communication, the emphasis is on the compositions of the fruiting body far beyond nutritional source with a focus on their pharmacologically active components and their therapeutic implications. In this connection, considerable attention has been given to the major components of the fungus, the polysaccharides, while small molecular weight drug-like molecules such as terpenoids and alkaloids have not been extensively studied. The chemistry and biological significance of all the bioactive compounds known from D. indusiata are herein scrutinised.

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Physiochemical and biological properties of phosphorylated polysaccharides from Dictyophora indusiata

Cited by 72 publications

References 33 publications

Comparison of the anti-duck hepatitis A virus activities of phosphorylated and sulfated Astragalus polysaccharides

Comparison of the anti-duck hepatitis A virus activities of phosphorylated and sulfated Astragalus polysaccharides

Molecular Modification of Polysaccharides and Resulting Bioactivities

The Chemistry, Pharmacology and Therapeutic Potential of the Edible Mushroom Dictyophora indusiata (Vent ex. Pers.) Fischer (Synn. Phallus indusiatus)

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