2022
DOI: 10.1117/1.ap.4.6.066001
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Physics-informed neural networks for diffraction tomography

Abstract: We propose a physics-informed neural network (PINN) as the forward model for tomographic reconstructions of biological samples. We demonstrate that by training this network with the Helmholtz equation as a physical loss, we can predict the scattered field accurately. It will be shown that a pretrained network can be fine-tuned for different samples and used for solving the scattering problem much faster than other numerical solutions. We evaluate our methodology with numerical and experimental results. Our PIN… Show more

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Cited by 22 publications
(8 citation statements)
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References 36 publications
(68 reference statements)
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“…To solve these reconstruction artifacts, convolutional neural networks have been trained in supervised or unsupervised settings, either using a fully-learned framework or in combination with a physical model [12][13][14][15][16][17]. Different approaches have been considered such as direct inversion, plug-and-play (PnP) priors, or physics-informed neural network (PINN) schemes.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…To solve these reconstruction artifacts, convolutional neural networks have been trained in supervised or unsupervised settings, either using a fully-learned framework or in combination with a physical model [12][13][14][15][16][17]. Different approaches have been considered such as direct inversion, plug-and-play (PnP) priors, or physics-informed neural network (PINN) schemes.…”
Section: Introductionmentioning
confidence: 99%
“…Saba et al used a PINN framework as forward model for tomographic reconstructions, showing feasibility of light scattering prediction from standard adherent cell cultures. Their work, however, has not yet been extended to more complex 3D objects like embryos or multicellular spheroids [13]. By coupling a laser scanning confocal microscope with a quantitative phase imaging module, Chen et al used supervised learning to achieve confocal sectioning on label-free images of neurons and liver-cancer spheroids.…”
Section: Introductionmentioning
confidence: 99%
“…Recently, computational imaging has become a research hotspot in optical field, especially phase retrieval [1][2][3][4] . Coherent diffraction imaging (CDI) [5,6] is a kind of phase retrieval technique using various iterative algorithms.…”
Section: Introductionmentioning
confidence: 99%
“…The network corrects the errors of PDEs by adding them to the loss function and using gradient descent optimization. Saba et al predicted the scattered field accurately with PINN [19]. It has also been applied to retrieve the effective permittivity parameters in nano-optics [20], reconstruct the tomography of biologic samples [19], quantify the microstructure of polycrystalline [21].…”
Section: Introductionmentioning
confidence: 99%
“…Saba et al predicted the scattered field accurately with PINN [19]. It has also been applied to retrieve the effective permittivity parameters in nano-optics [20], reconstruct the tomography of biologic samples [19], quantify the microstructure of polycrystalline [21]. Additionally, Lu et al developed a Python library called DeepXDE that employs PINN to solve problems in computational science and engineering [22].…”
Section: Introductionmentioning
confidence: 99%