Physicochemical study of water-soluble C60(OH)24 fullerenol

Sharoyko, Vladimir V.; Ageev, Sergei V.; Meshcheriakov, Anatolii A.; Akentiev, Alexander V.; Noskov, Boris A.; Rakipov, Ilnaz T.; Чарыков, Н. А.; Куленова, Н. А.; Shaimardanova, B. K.; Podolsky, Nikita E.; Semenov, Konstantin N.

doi:10.1016/j.molliq.2020.113360

Cited by 19 publications

(10 citation statements)

References 36 publications

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“…are formed from first-order associates, and so on. The aqueous solutions of C60( themselves are characterized by huge positive deviations from ideality, which often to the loss of diffusion stability by the solution [15][16][17]. It is unlikely that in saturated aqueous solutions PrCl3-C60(OH)24-H2O, Nd C60(OH)24-H2O, YCl3-C60(OH)24-H2O, TbCl3-C60(OH)24-H2O electrolytes NdCl3, YCl3, and TbCl3 can be considered as very strong, it is likely the formation pairs and larger ion associates in solutions.…”

Section: Ln(c 0 C60(oh)24/cc60(oh)24) = a S Cremcl3mentioning

confidence: 99%

“…ln(m 0 C60(OH)24/mC60(OH) The C 60 (OH) 24 nanoclusters themselves form a complex hierarchical sequence of associates: First-order associates are formed from monomers, then second-order associates are formed from first-order associates, and so on. The aqueous solutions of C 60 (OH) 24 themselves are characterized by huge positive deviations from ideality, which often lead to the loss of diffusion stability by the solution [15,16].…”

Section: Ln(c 0 C60(oh)24/cc60(oh)24) = a S Cremcl3mentioning

confidence: 99%

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Solubility of Rare Earth Chlorides in Ternary Water-Salt Systems in the Presence of a Fullerenol—C60(OH)24 Nanoclusters at 25 °C. Models of Nonelectrolyte Solubility in Electrolyte Solutions

et al. 2021

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The solubility in triple water-salt systems containing NdCl3, PrCl3, YCl3, TbCl3 chlorides, and water-soluble fullerenol C60(OH)24 at 25 °C was studied by isothermal saturation in ampoules. The analysis for the content of rare earth elements was carried out by atomic absorption spectroscopy, for the content of fullerenol—by electronic spectrophotometry. The solubility diagrams in all four ternary systems are simple eutonic, both consisting of two branches, corresponding to the crystallization of fullerenol crystal-hydrate and rare earth chloride crystal-hydrates, and containing one nonvariant point corresponding to the saturation of both solid phases. On the long branches of C60(OH)24*18H2O crystallization, a C60(OH)24 decreases by more than 2 orders of magnitude compared to the solubility of fullerenol in pure water (salting-out effect). On very short branches of crystallization of NdCl3*6H2O, PrCl3*7H2O, YCl3*6H2O, and TbCl3*6H2O, the salting-in effect is clearly observed, and the solubility of all four chlorides increases markedly. The four diagrams cannot be correctly approximated by the simple one-term Sechenov equation (SE-1), and very accurately approximated by the three-term modified Sechenov equation (SEM-3). Both equations for the calculation of nonelectrolyte solubility in electrolyte solutions (SE-1 and SEM-3 models) are obtained, using Pitzer model of virial decomposition of excess Gibbs energy of electrolyte solution. It is shown, that semi-empirical equations of SE-1 and SEM-3 models may be extended to the systems with crystallization of crystal-solvates.

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Section: Ln(c 0 C60(oh)24/cc60(oh)24) = a S Cremcl3mentioning

confidence: 99%

Section: Ln(c 0 C60(oh)24/cc60(oh)24) = a S Cremcl3mentioning

confidence: 99%

Solubility of Rare Earth Chlorides in Ternary Water-Salt Systems in the Presence of a Fullerenol—C60(OH)24 Nanoclusters at 25 °C. Models of Nonelectrolyte Solubility in Electrolyte Solutions

et al. 2021

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“…Like other carbon nanostructures, fullerenes are not toxic to the human body [12][13][14]. The doping of fullerenes results in a wide family of derivative compounds, which possess a wide variety of physical and chemical characteristics, including adsorption properties, electronic structure and solubility [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Ab Initio Insight into the Interaction of Metal-Decorated Fluorinated Carbon Fullerenes with Anti-COVID Drugs

Katin

Kochaev

El-Hajjaji

et al. 2022

IJMS

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We theoretically investigated the adsorption of two common anti-COVID drugs, favipiravir and chloroquine, on fluorinated C60 fullerene, decorated with metal ions Cr3+, Fe2+, Fe3+, Ni2+. We focused on the effect of fluoridation on the interaction of fullerene with metal ions and drugs in an aqueous solution. We considered three model systems, C60, C60F2 and C60F48, and represented pristine, low-fluorinated and high-fluorinated fullerenes, respectively. Adsorption energies, deformation of fullerene and drug molecules, frontier molecular orbitals and vibrational spectra were investigated in detail. We found that different drugs and different ions interacted differently with fluorinated fullerenes. Cr3+ and Fe2+ ions lead to the defluorination of low-fluorinated fullerenes. Favipiravir also leads to their defluorination with the formation of HF molecules. Therefore, fluorinated fullerenes are not suitable for the delivery of favipiravir and similar drugs molecules. In contrast, we found that fluorine enhances the adsorption of Ni2+ and Fe3+ ions on fullerene and their activity to chloroquine. Ni2+-decorated fluorinated fullerenes were found to be stable and suitable carriers for the loading of chloroquine. Clear shifts of infrared, ultraviolet and visible spectra can provide control over the loading of chloroquine on Ni2+-doped fluorinated fullerenes.

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“…This adduct was obtained under mild conditions by alkaline hydrolysis of a bromo derivative C 60 Br 24 . The use of this technique made it possible to obtain a reproducible composition of the final product with a minimum content of impurity groups. ,− Thus, in this work, for the first time, a comprehensive study of the biocompatibility of the aqueous C 60 (OH) 24 solutions was carried out.…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Silico Investigation of Water-Soluble Fullerenol C₆₀(OH)₂₄: Bioactivity and Biocompatibility

et al. 2021

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Light fullerenes, C 60 and C 70 , have significant potential in biomedical applications due to their ability to absorb reactive oxygen species, inhibit the development of tumors, inactivate viruses and bacteria, and as the basis for developing systems for targeted drug delivery. However, the hydrophobicity of individual fullerenes complicates their practical use; therefore, creating water-soluble derivatives of fullerenes is increasingly important. Currently, the most studied soluble adducts of fullerenes are polyhydroxy fullerenes or fullerenols. Unfortunately, investigations of fullerenol biocompatibility are fragmental. They often lack reproducibility both in the synthesis of the compounds and their biological action. We here investigate the biocompatibility of a welldefined fullerenol C 60 (OH) 24 obtained using methods that minimize the content of impurities and quantitatively characterize the product's composition. We carry out comprehensive biochemical and biophysical investigations of C 60 (OH) 24 that include photodynamic properties, cyto-and genotoxicity, hemocompatibility (spontaneous and photo-induced hemolysis, platelet aggregation), and the thermodynamic characteristics of C 60 (OH) 24 binding to human serum albumin and DNA. The performed studies show good biocompatibility of fullerenol C 60 (OH) 24 , which makes it a promising object for potential use in biomedicine.

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Physicochemical study of water-soluble C60(OH)24 fullerenol

Cited by 19 publications

References 36 publications

Solubility of Rare Earth Chlorides in Ternary Water-Salt Systems in the Presence of a Fullerenol—C60(OH)24 Nanoclusters at 25 °C. Models of Nonelectrolyte Solubility in Electrolyte Solutions

Solubility of Rare Earth Chlorides in Ternary Water-Salt Systems in the Presence of a Fullerenol—C60(OH)24 Nanoclusters at 25 °C. Models of Nonelectrolyte Solubility in Electrolyte Solutions

Ab Initio Insight into the Interaction of Metal-Decorated Fluorinated Carbon Fullerenes with Anti-COVID Drugs

In Vitro and In Silico Investigation of Water-Soluble Fullerenol C₆₀(OH)₂₄: Bioactivity and Biocompatibility

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Physicochemical study of water-soluble C60(OH)24 fullerenol

Cited by 19 publications

References 36 publications

Solubility of Rare Earth Chlorides in Ternary Water-Salt Systems in the Presence of a Fullerenol—C60(OH)24 Nanoclusters at 25 °C. Models of Nonelectrolyte Solubility in Electrolyte Solutions

Solubility of Rare Earth Chlorides in Ternary Water-Salt Systems in the Presence of a Fullerenol—C60(OH)24 Nanoclusters at 25 °C. Models of Nonelectrolyte Solubility in Electrolyte Solutions

Ab Initio Insight into the Interaction of Metal-Decorated Fluorinated Carbon Fullerenes with Anti-COVID Drugs

In Vitro and In Silico Investigation of Water-Soluble Fullerenol C60(OH)24: Bioactivity and Biocompatibility

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In Vitro and In Silico Investigation of Water-Soluble Fullerenol C₆₀(OH)₂₄: Bioactivity and Biocompatibility