Physicochemical Regulation of TGF and VEGF Delivery From Mesoporous Calcium Phosphate Bone Substitutes

Möller-Siegert, Janina; Parmentier, Julien; Laquerrière, Patrice; Ouadi, Ali; Raissle, Olivier; Jallot, Édouard; Nédélec, Jean-Marie; Vix‐Guterl, Cathie; Anselme, Karine

doi:10.2217/nnm-2017-0158

Cited by 7 publications

(4 citation statements)

References 47 publications

(63 reference statements)

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“…To maintain the long-term effects, an excess dose of growth factors is commonly adopted (Lee et al 2011). Previous research has shown that the initial burst release of growth factors inhibits cell proliferation and differentiation, resulting in clinical complications such as ectopic bone formation or abnormal bone resorption (James et al 2016; Mller-Siegert et al 2017). Therefore, synthesizing a special material that interacts with the particular domain of growth factors and avoids the initial burst release may be key to optimizing their effects.…”

Section: Discussionmentioning

confidence: 99%

Odontogenic Differentiation Induced by TGF-β1 Binding Peptide–Modified Bioglass

Mao

et al. 2022

J Dent Res

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Emerging evidence suggests that growth factors are crucial in regenerative endodontic therapy. To achieve the desired effects, the systematic administration of supraphysiologic concentrations of exogenous growth factors is commonly performed, but this is usually associated with high costs, technique, and safety issues. Here, we describe a novel biomaterial that can manipulate endogenous growth factors without the need for adding exogenous growth factors. Transforming growth factor β1 binding peptide (TGFp) was grafted onto the surface of a neutral pH phytic acid–derived bioactive glass (PSC) to synthesize modified bioactive glass (PSC-TGFp). Fourier transform infrared spectroscopy and thermogravimetric analysis results demonstrated that the TGFp was successfully grafted to the surface of the PSC. Scanning electron microscopy and x-ray diffraction showed that PSC-TGFp possessed good in vitro bioactivity. After soaking in simulated body fluid for 24 h, hydroxyapatite formed on the surface of PSC-TGFp. Enzyme-linked immunosorbent assay showed that PSC-TGFp could capture endogenous transforming growth factor β1 from dentin matrix–extracted proteins (DMEP) and release it slowly over 21 d. Cytologic experiments revealed that PSC-TGFp after adsorbing DMEP could enhance the adhesion, migration, viability, and odontogenic differentiation of stem cells from apical papilla. The results highlight that PSC-TGFp may be a promising biomaterial to manipulate endogenous growth factors for regenerative endodontic therapy in the future.

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Section: Discussionmentioning

confidence: 99%

Odontogenic Differentiation Induced by TGF-β1 Binding Peptide–Modified Bioglass

Mao

et al. 2022

J Dent Res

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“…The ceramic phase was modified by the adsorption process. Based on the results, from 0 to 50% of the initial TGF-β1 loading was released in a culture medium after 3 to 6 days [ 38 ]. Using the cryogenic 3D printing technique, bi-layered osteochondral scaffolds were designed.…”

Section: Protein Biomoleculesmentioning

confidence: 99%

Polymeric and Composite Carriers of Protein and Non-Protein Biomolecules for Application in Bone Tissue Engineering

et al. 2023

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Conventional intake of drugs and active substances is most often based on oral intake of an appropriate dose to achieve the desired effect in the affected area or source of pain. In this case, controlling their distribution in the body is difficult, as the substance also reaches other tissues. This phenomenon results in the occurrence of side effects and the need to increase the concentration of the therapeutic substance to ensure it has the desired effect. The scientific field of tissue engineering proposes a solution to this problem, which creates the possibility of designing intelligent systems for delivering active substances precisely to the site of disease conversion. The following review discusses significant current research strategies as well as examples of polymeric and composite carriers for protein and non-protein biomolecules designed for bone tissue regeneration.

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“…Impressively, the introduction of BMP-2 loading also improved the degradation efficiency of BCP and enhanced its biocompatibility [ 70 ]. Similarly, growth factors represented by vascular endothelial growth factor (VEGF) were also loaded on CaP NPs to promote bone defect repair and local vascular regeneration [ 71 – 73 ].…”

Section: The Delivery Vehicle Of Nanomedicinementioning

confidence: 99%

The advances in nanomedicine for bone and cartilage repair

Qiao

Tang

et al. 2022

J Nanobiotechnol

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With the gradual demographic shift toward an aging and obese society, an increasing number of patients are suffering from bone and cartilage injuries. However, conventional therapies are hindered by the defects of materials, failing to adequately stimulate the necessary cellular response to promote sufficient cartilage regeneration, bone remodeling and osseointegration. In recent years, the rapid development of nanomedicine has initiated a revolution in orthopedics, especially in tissue engineering and regenerative medicine, due to their capacity to effectively stimulate cellular responses on a nanoscale with enhanced drug loading efficiency, targeted capability, increased mechanical properties and improved uptake rate, resulting in an improved therapeutic effect. Therefore, a comprehensive review of advancements in nanomedicine for bone and cartilage diseases is timely and beneficial. This review firstly summarized the wide range of existing nanotechnology applications in the medical field. The progressive development of nano delivery systems in nanomedicine, including nanoparticles and biomimetic techniques, which are lacking in the current literature, is further described. More importantly, we also highlighted the research advancements of nanomedicine in bone and cartilage repair using the latest preclinical and clinical examples, and further discussed the research directions of nano-therapies in future clinical practice. Graphical Abstract

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Physicochemical Regulation of TGF and VEGF Delivery From Mesoporous Calcium Phosphate Bone Substitutes

Abstract: Our findings highlight that the strong affinity of GFs with the ceramic surfaces, demonstrated by a slow GFs release, is enhanced by the large surface area, confinement into mesopores of ceramics and high difference of surface charge between ceramic surfaces and GFs.

Cited by 7 publications

References 47 publications

Odontogenic Differentiation Induced by TGF-β1 Binding Peptide–Modified Bioglass

Odontogenic Differentiation Induced by TGF-β1 Binding Peptide–Modified Bioglass

Polymeric and Composite Carriers of Protein and Non-Protein Biomolecules for Application in Bone Tissue Engineering

The advances in nanomedicine for bone and cartilage repair

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