compete with conventional processes has developed. Supercritical fluid extraction (SFE) is a more environmentally friendly technology for natural ingredient extraction from food materials. [4] In 1822, Baron Cagniard de la Tour first discovered the supercritical phase of solvents, and then in 1879, Hannay and Hogarth investigated the application of supercritical fluids. [5,6] Practical applications were then used for decaffeination process of green coffee beans in Germany. [7] In the following decades, the technology has undergone rapid development, and now, it is not only applied in laboratories for research purpose but also in industries for commercial use to produce natural food components, nutraceuticals, and pharmaceuticals. [8][9][10][11] In recent years, some extraction processes have been classified as innovative and nonconventional technologies. SFE together with ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), and pressure liquid extraction (PLE) are some of these techniques that aroused interest. [12] UAE employs high-intensity ultrasonic waves to break cell walls and results in solvent diffusion. MAE introduces electric and magnetic field to promote heat transfer and conduction, leading to a dipole moment between solvent and sample. The main advantage of UAE and MAE is the significant reduction in extraction time, consequently leading to reduction in solvent consumption and relatively low additional cost. However, UAE/MAE has the limitations of low selectivity, solvent use, and energy consumption. PLE is one of the highpressure extraction techniques with advantages of time saving, automation, selective and efficient extraction utilizing low solvent volumes, but the negative effect of temperature on the extract of some natural matrices should be paid more attentions. SFE employs supercritical fluids as solvent to extract bioactive compounds. It has several advantages due to the high diffusion coefficient and low viscosity of supercritical fluid. [13,14] Supercritical fluid has low surface tension and can easily penetrate the pores of solid matrix with increased extraction efficiency. Since the fluid density of a supercritical fluid is very sensitive to the changes of temperature or pressure at the critical point, extraction selectivity could be realized by modifying the conditions of temperature and pressure, which could affect the solubility of the various components contained in the supercritical fluid. SFE is usually performed at reduced temperature without oxygen and light; thus, thermal degradation and oxygen reaction can be prevented, and the biological properties of extracts Supercritical fluid extraction (SFE) is an eco-friendly technology that has attracted a great amount of attention in the food and nutraceutical industries due to its considerable benefits over conventional techniques. It has high selectivity and can be employed to extract heat sensitive, easily oxidized compounds with high efficiency. Less organic solvent is used during extraction, leaving no toxic ...