Physicochemical properties, pharmacokinetics, toxicology and application of nanocarriers

Cai, Xiaoli; Jin, Ming Fang; Yao, Longfukang; He, Bin; Ahmed, Saeed; Safdar, Waseem; Ahmad, Ijaz; Cheng, Dong‐Bing; Lei, Zhixin; Sun, Taolei

doi:10.1039/d2tb02001g

Cited by 10 publications

(3 citation statements)

References 133 publications

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“…The drug release from a carrier depends on various factors, such as drug movement, carrier degradation, swelling, and interaction with guest molecules. 126 To better understand the drug release process, data from drug release studies were fitted into different mathematical kinetic release models and their formulas are presented in Table S4 (ESI †). These models are described below.…”

Section: Kinetic Studymentioning

confidence: 99%

A multivariate metal–organic framework based pH-responsive dual-drug delivery system for chemotherapy and chemodynamic therapy

Akbar,

Saddozai

et al. 2023

Mater. Adv.

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Section: Kinetic Studymentioning

confidence: 99%

A multivariate metal–organic framework based pH-responsive dual-drug delivery system for chemotherapy and chemodynamic therapy

Akbar,

Saddozai

et al. 2023

Mater. Adv.

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“…Unsolved issues like incomplete knowledge of nanocarrier elimination in vivo, potential toxicity, and unaccounted-for pharmacokinetic behavior prevent nanocarriers from being used clinically for drug delivery. Hence, it is important to focus not only on drug delivery at the nanoscale but also on developing stable, low-toxicity, clinically applicable nanoscale frameworks for drug delivery [ 217 ].…”

Section: Biopharmaceutics and Pharmacokinetics Considerationsmentioning

confidence: 99%

Controlled Drug Release from Nanoengineered Polysaccharides

Bayer

2023

Pharmaceutics

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Polysaccharides are naturally occurring complex molecules with exceptional physicochemical properties and bioactivities. They originate from plant, animal, and microbial-based resources and processes and can be chemically modified. The biocompatibility and biodegradability of polysaccharides enable their increased use in nanoscale synthesis and engineering for drug encapsulation and release. This review focuses on sustained drug release studies from nanoscale polysaccharides in the fields of nanotechnology and biomedical sciences. Particular emphasis is placed on drug release kinetics and relevant mathematical models. An effective release model can be used to envision the behavior of specific nanoscale polysaccharide matrices and reduce impending experimental trial and error, saving time and resources. A robust model can also assist in translating from in vitro to in vivo experiments. The main aim of this review is to demonstrate that any study that establishes sustained release from nanoscale polysaccharide matrices should be accompanied by a detailed analysis of drug release kinetics by modeling since sustained release from polysaccharides not only involves diffusion and degradation but also surface erosion, complicated swelling dynamics, crosslinking, and drug-polymer interactions. As such, in the first part, we discuss the classification and role of polysaccharides in various applications and later elaborate on the specific pharmaceutical processes of polysaccharides in ionic gelling, stabilization, cross-linking, grafting, and encapsulation of drugs. We also document several drug release models applied to nanoscale hydrogels, nanofibers, and nanoparticles of polysaccharides and conclude that, at times, more than one model can accurately describe the sustained release profiles, indicating the existence of release mechanisms running in parallel. Finally, we conclude with the future opportunities and advanced applications of nanoengineered polysaccharides and their theranostic aptitudes for future clinical applications.

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“…And it is favorable for the metabolism of amphiphilic copolymers. 16 As for hyperbranched polymer-based unimolecular micelles, their superior stable covalent skeleton could efficiently inhibit premature drug leakage caused by demicellization, but in the meantime, the release of the drug molecules either encapsulated or conjugated in their hydrophobic cores is restricted. Moreover, metabolism of the hydrophobic skeleton is still a challenge.…”

Section: Introductionmentioning

confidence: 99%

GSH-triggered disintegrable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific chemotherapy

Li,

Yang,

Liu

2023

Polym. Chem.

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Physicochemical properties, pharmacokinetics, toxicology and application of nanocarriers

Abstract: As an effective delivery nanosystem for drug controlled-release, nanocarriers (NCs) have been investigated widely. Although various studies have focused on the preparation and characterization of nanoparticles, clinical applications are rarely...

Cited by 10 publications

References 133 publications

A multivariate metal–organic framework based pH-responsive dual-drug delivery system for chemotherapy and chemodynamic therapy

A multivariate metal–organic framework based pH-responsive dual-drug delivery system for chemotherapy and chemodynamic therapy

Controlled Drug Release from Nanoengineered Polysaccharides

GSH-triggered disintegrable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific chemotherapy

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