Physicochemical properties of peptide-coated microelectrode arrays and their in vitro effects on neuroblast cells

Ghane-Motlagh, Bahareh; Javanbakht, Taraneh; Shoghi, Fatemeh; Wilkinson, Kevin J.; Martel, Richard

doi:10.1016/j.msec.2016.06.045

Cited by 19 publications

(15 citation statements)

References 42 publications

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“…Coatings of ECM derived poly‐ d ‐lysine (PDL) and neuroadhesive L1 have also been shown to impact biocompatibility of MEAs in a significant way. Ghane‐Motlagh et al tested the effectiveness of PDL coatings on increasing neural cell adhesion and proliferation on the surface of silicon MEAs coated with polyethylene glycol (PEG) and Perylene‐C. It was discovered that neuroblast cells cultured on the MEA surface preferred to grow on the tips coated with PDL compared to uncoated MEAs.…”

Section: Microelectrode Array Modifications For Improving the Neural mentioning

confidence: 99%

A Critical Review of Microelectrode Arrays and Strategies for Improving Neural Interfaces

Ferguson

Sharma

Ross

et al. 2019

Adv Healthcare Materials

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Though neural interface systems (NISs) can provide a potential solution for mitigating the effects of limb loss and central nervous system damage, the microelectrode array (MEA) component of NISs remains a significant limiting factor to their widespread clinical applications. Several strategies can be applied to MEA designs to increase their biocompatibility. Herein, an overview of NISs and their applications is provided, along with a detailed discussion of strategies for alleviating the foreign body response (FBR) and abnormalities seen at the interface of MEAs and the brain tissue following MEA implantation. Various surface modifications, including natural/synthetic surface coatings, hydrogels, and topography alterations, have shown to be highly successful in improving neural cell adhesion, reducing gliosis, and increasing MEA longevity. Different MEA surface geometries, such as those seen in the Utah and Michigan arrays, can help alleviate the resultant FBR by reducing insertion damage, while providing new avenues for improving MEA recording performance and resolution. Increasing overall flexibility of MEAs as well as reducing their stiffness is also shown to reduce MEA induced micromotion along with FBR severity. By combining multiple different properties into a single MEA, the severity and duration of an FBR postimplantation can be reduced substantially.

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Section: Microelectrode Array Modifications For Improving the Neural mentioning

confidence: 99%

A Critical Review of Microelectrode Arrays and Strategies for Improving Neural Interfaces

Ferguson

Sharma

Ross

et al. 2019

Adv Healthcare Materials

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show abstract

“…Previously, some devices' physical and biological properties were studied with different methods [46][47][48][49]. The physicochemical properties of some polymers and nanomaterials have also been investigated during recent years [50][51][52][53].…”

Section: Discussionmentioning

confidence: 99%

Rheological Properties of Superparamagnetic Iron Oxide Nanoparticles

Javanbakht¹,

Laurent

Stanicki

et al. 2021

JES

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The present study focuses on the rheological properties of polyethylene glycol (PEG) modified, positively charged, and negatively charged superparamagnetic iron oxide nanoparticles (SPIONs) at different temperatures. We hypothesized that the surface properties of these nanoparticles in the water did not affect their rheological properties. These nanoparticles had not the same surface properties as SPIONs-PEG had not to charge on their surface whereas positively charged and negatively charged ones with amine and carboxyl groups as their surfaces had positive and negative surface charges, respectively. However, their rheological behaviors were not different from each other. The comparative rheological study of SPIONs revealed their pseudo-Newtonian behavior. The viscosity of SPIONs decreased with the increase in temperature. At low shear rates, the shear stress of SPIONs was independent of rate and increased with the increase of rate. Moreover, at high shear rates, the shear stress for PEG-SPIONs was more than those for positively charged and negatively charged SPIONs. These measurements also revealed that at high shear rates, the shear stress of samples decreased with the increase of temperature. The shear stress of samples decreased with the increase of shear strain and the temperature. We also observed that all the samples had the same amount of shear strain at each shear stress, which indicated the exact resistance of SPIONs to deformation. Furthermore, the shear modulus decreased with time for these nanoparticles. These results suggest that these nanoparticles are promising candidates with appropriate properties for fluid processing applications and drug vectors in biomedical applications.

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“…Cells grew and proliferated normally in the presence of Pt and CNT-coated electrodes. CNTs remained mechanically stable and attached to the electrode tips after PDL deposition and cell culture process [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Direct Growth of Carbon Nanotubes on New High-Density 3D Pyramid-Shaped Microelectrode Arrays for Brain-Machine Interfaces

et al. 2016

Self Cite

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Silicon micromachined, high-density, pyramid-shaped neural microelectrode arrays (MEAs) have been designed and fabricated for intracortical 3D recording and stimulation. The novel architecture of this MEA has made it unique among the currently available micromachined electrode arrays, as it has provided higher density contacts between the electrodes and targeted neural tissue facilitating recording from different depths of the brain. Our novel masking technique enhances uniform tip-exposure for variable-height electrodes and improves process time and cost significantly. The tips of the electrodes have been coated with platinum (Pt). We have reported for the first time a selective direct growth of carbon nanotubes (CNTs) on the tips of 3D MEAs using the Pt coating as a catalyzer. The average impedance of the CNT-coated electrodes at 1 kHz is 14 kΩ. The CNT coating led to a 5-fold decrease of the impedance and a 600-fold increase in charge transfer compared with the Pt electrode.

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Physicochemical properties of peptide-coated microelectrode arrays and their in vitro effects on neuroblast cells

Cited by 19 publications

References 42 publications

A Critical Review of Microelectrode Arrays and Strategies for Improving Neural Interfaces

A Critical Review of Microelectrode Arrays and Strategies for Improving Neural Interfaces

Rheological Properties of Superparamagnetic Iron Oxide Nanoparticles

Direct Growth of Carbon Nanotubes on New High-Density 3D Pyramid-Shaped Microelectrode Arrays for Brain-Machine Interfaces

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