Physicochemical Properties of Natural Based Products versus Synthetic Chemicals

Zaid, Hilal; Raiyn, Jamal; Nasser, Ahmed; Saad, Bashar; Rayan, Anwar

doi:10.2174/18763960010030100194

Cited by 20 publications

(19 citation statements)

References 43 publications

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“…Natural products have been optimized to interact with biological systems through a long natural selection process (9), and because of this, nature is considered the best concocter of medicines and has been a source of medicines for millennia (10)(11)(12)(13). During the last two decades, various plants have been tested for their antimicrobial activity and many of them exhibit significant antibacterial activity against Streptococcus species (14).…”

Section: Inhibitory Capacity Of Rhus Coriaria L Extract and Its Majomentioning

confidence: 99%

Inhibitory capacity of Rhus coriaria L. extract and its major component methyl gallate on Streptococcus mutans biofilm formation by optical profilometry: Potential applications for oral health

Kačergius

Abu‐Lafi

Kirkliauskienė

et al. 2017

Molecular Medicine Reports

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Streptococcus mutans (S. mutans) bacterium is the most well recognized pathogen involved in pathogenesis of dental caries. Its virulence arises from its ability to produce a biofilm and acidogenicity, causing tooth decay. Discovery of natural products capable to inhibit biofilm formation is of high importance for developing health care products. To the best of our knowledge, in all previous scientific reports, a colorimetric assay was applied to test the effect of sumac and methyl gallate (MG) on S. mutans adherence. Quantitative assessment of the developed biofilm should be further performed by applying an optical profilometry assay, and by testing the effect on both surface roughness and thickness parameters of the biofilm. To the best of our knowledge, this is the first study to report the effect of sumac extract and its constituent MG on biofilm formation using an optical profilometry assay. Testing antibacterial activity of the sumac extract and its fractions revealed that MG is the most bioactive component against S. mutans bacteria. It reduced S. mutans biofilm biomass on the polystyrene surface by 68‑93%, whereas 1 mg/ml MG was able to decrease the biofilm roughness and thickness on the glass surface by 99%. MG also prevented a decrease in pH level by 97%. These bioactivities of MG occurred in a dose‑dependent manner and were significant vs. untreated bacteria. The findings are important for the development of novel pharmaceuticals and formulations of natural products and extracts that possess anti‑biofilm activities with primary applications for oral health, and in a broader context, for the treatment of various bacterial infections.

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Section: Inhibitory Capacity Of Rhus Coriaria L Extract and Its Majomentioning

confidence: 99%

Inhibitory capacity of Rhus coriaria L. extract and its major component methyl gallate on Streptococcus mutans biofilm formation by optical profilometry: Potential applications for oral health

Kačergius

Abu‐Lafi

Kirkliauskienė

et al. 2017

Molecular Medicine Reports

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“…However, the global expenditures on drug research have doubled since 1991 [4]. This situation has changed with a shift back to natural-based products, which are believed to be better tolerated by the human body [5]. Nutritional factors are also recognized to play a key role in the prevention of, and therapy for, many ailments [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, nature is rich in bioactive ingredients in general [28,29], and antioxidants are rich in particular [30]. Nature has been considered the best source of medicines for millennia [31], and most marketed drugs have natural origins [5].…”

Section: Introductionmentioning

confidence: 99%

Correlation between Antibacterial Activity and Free-Radical Scavenging: In-Vitro Evaluation of Polar/Non-Polar Extracts from 25 Plants

et al. 2020

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Objectives: The current study aimed to measure the antioxidant and antibacterial activities of 25 wild Palestinian edible plants, which were subjected to extraction by polar and non-polar solvents. Correlations between free radical scavenging activity and antibacterial activity of the extracts were assessed for both polar and non-polar fractions. Materials: Twenty-five wild edible plant species that are frequently consumed by people in Palestine (mainly in a rural area) were examined. Among them, 10 plant species were among those with the highest mean cultural importance values, according to an ethnobotanical survey that was conducted in the West Bank, Palestine, a few years ago. Method: The protocol of the DPPH assay for testing free-radical scavenging was utilized for determining EC50 values, while microdilution tests were conducted to determine the 50% inhibitory concentration (IC50) of the extracts for the microorganism Staphylococcus mutans. Results and Discussion: Eight extracts (non-polar fractions) were found to possess an antibacterial IC50 of less than 20 ppm, such as Foeniculum vulgare, Salvia palaestinafruticose, Micromeria fruticose, Trigonella foenum-graecum, Cichorium pumilum jacq, Salvia hierosolymitana boiss, Ruta chalepensis, and Chrysanthemum coronarium. The polar fractions possess higher antioxidant activity, while non-polar fraction possess higher antibacterial activity. Looking at all the results together can deceive and lead to the conclusion that there is no correlation between antibacterial activity against S. mutans and free radical scavenging (R2 equals 0.0538). However, in-depth analysis revealed that non-polar plant extracts with an EC50 of free radical scavenging ≤100 ppm have a four-fold order of enrichment toward more activity against S. mutans. These findings are of high importance for screening projects. A four-fold order of enrichment could save plenty of time and many in screening projects. The antibacterial active extracts marked by low-medium free radical scavenging might act through a mechanism of action other than that of highly active, free radical scavenging extracts. Conclusion: The screening of antioxidant and antimicrobial activity performed on 25 selected wild plant extracts revealed a satisfactory free radical scavenging and antimicrobial potential that could be of value in the management of oxidative stress. Further studies are recommended to explore novel and highly active natural antibacterial products.

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“…This could add weight to the argument that natural based products are inherently better tolerated in the body than synthetic chemicals and have higher chance to be approved as drugs [1,2]. Natural product-based medicines, particularly, herbal-based drugs represented about 60-80 percent of all drugs in use by 1990 [3,4].…”

Section: Introductionmentioning

confidence: 99%

Anticancer Activity of Anise (Pimpinella anisum L.) Seed Extract

Kadan¹

2013

TONUTRAJ

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Cancer incidence is much lower in India than in western countries. The reason is not fully understood, but the high spice consumption could be one of the contributing factors. Anise is one of the plants grows in India and people from our region believe that anise seeds are helpful in cancer prevention and treatment. In this study, anticancer activity of ethanol extract of anise (Pimpinella anisum L.) seed was investigated. MTT and LDH assays revealed that ethanolic extract have cytotoxic activity on human prostate cancer cell line at concentrations found safe to normal cells (rat skeletal muscle cell line [L6]). Treatment with anise seeds extract caused anti proliferative and apoptotic effects, with IC50 value of 400 µg/mL to cancer cells. Thus, anise could be one of the foods that attribute to cancer prevention and treatment. It could also be a natural source of novel anticancer compounds with anti proliferative and/or apoptotic properties and it is worth to work on for isolation and identification of novel anticancer drug candidates.

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Physicochemical Properties of Natural Based Products versus Synthetic Chemicals

Cited by 20 publications

References 43 publications

Inhibitory capacity of Rhus coriaria L. extract and its major component methyl gallate on Streptococcus mutans biofilm formation by optical profilometry: Potential applications for oral health

Inhibitory capacity of Rhus coriaria L. extract and its major component methyl gallate on Streptococcus mutans biofilm formation by optical profilometry: Potential applications for oral health

Correlation between Antibacterial Activity and Free-Radical Scavenging: In-Vitro Evaluation of Polar/Non-Polar Extracts from 25 Plants

Anticancer Activity of Anise (Pimpinella anisum L.) Seed Extract

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