Physicochemical properties, biological activity and biocompatibility of water-soluble C60-Hyp adduct

Meshcheriakov, Anatolii A.; Iurev, Gleb O.; Luttsev, Michail D.; Podolsky, Nikita E.; Ageev, Sergei V.; Petrov, Andrey V.; Vasina, Lubov V.; Solovtsova, Irina L.; Sharoyko, Vladimir V.; Murin, I. V.; Semenov, Konstantin N.

doi:10.1016/j.colsurfb.2020.111338

Cited by 14 publications

(3 citation statements)

References 33 publications

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“…Fig. 7 shows the concentration dependence of the degree of haemolysis in the presence of atranorin after 1 and 3 h. Analysis of the results obtained indicates that atranorin can be considered haemocompatible in the concentration range of 1-100 μM since the degree of haemolysis does not exceed 5 % 30,54,55 .…”

Section: Haemocompatibilitymentioning

confidence: 97%

Atranorin is a novel potential candidate drug for treating myelodysplastic syndrome

Semenov,

Prokopiev,

Petukhova

et al. 2024

Preprint

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This work is devoted to the study of biocompatibility, cyto- and genotoxicity, mechanism of action and prospects for the use of atranorin, which is an AKT kinase inhibitor, for the treatment of myelodysplastic syndrome. Atranorin was isolated by preparative flash chromatography; identification was carried out by UV, IR, and NMR spectroscopy, mass spectrometry, and elemental analysis. Biocompatibility studies included studies of haemocompatibility, genotoxicity, antioxidant activity, cytotoxicity against ECV340 and HEK293 cell lines. Computer modelling of the interaction of atranorin with AKT kinase was carried out using docking followed by molecular dynamics of the resulting complexes; the ADMET properties of atranorin were also calculated. Flow cytometry included analysis of the expression level of PD-L1 and TIM-3 in the presence of atranorin on THP-1, Mono-Mac-1 and KG-1 cell lines, as well as human bone marrow cells.

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Section: Haemocompatibilitymentioning

confidence: 97%

Atranorin is a novel potential candidate drug for treating myelodysplastic syndrome

Semenov,

Prokopiev,

Petukhova

et al. 2024

Preprint

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“…Their application in various branches of scientific research and technology is often associated with the use of these compounds in solutions. Water-based systems are examined in order to reveal the antioxidant properties of fullerenes [6] and biocompatibility [7,8] to study the environmental impact and related problems [9][10][11]. Therefore, different modifications and improvements of the introduction of fullerenes into water were proposed [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Colloid Chemistry of Fullerene Solutions: Aggregation and Coagulation

Mchedlov-Petrossyan,

Marfunin,

Kriklya

2023

Liquids

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This review article is devoted to the colloidal properties of fullerene solutions. According to generally accepted understandings, all solvents in relations to fullerenes are divided into “good”, “poor”, and “reactive”. We have consistently considered the state of fullerenes in these systems. In “good”, predominantly non-polar aromatic solvents and CS2, non-equilibrium dissolution methods lead to the formation of colloidal aggregates, whereas the utilization of equilibrium methods results in the formation of molecular solutions. The latter, however, have some unusual properties; new results considered in this review confirm previously expressed ideas about colloidal properties of these solutions. In “poor” (polar) solvents, lyophobic colloidal systems appear. Both “bottom-up” and “top-down” methods of preparation are well documented in the literature. However, N-methylpyrrolidine-2-one, DMSO, and DMF dissolve fullerenes quite easily and with less energy consumption. These solvents can be considered a subset of “poor” solvents that have some features of being “reactive” at the expense of basic properties. New data confirm that hydrosols of fullerenes are typical hydrophobic colloids that obey the Schulze–Hardy rule and other regularities in the presence of electrolytes. Organosols in acetonitrile and methanol are much less stable with respect to the effects of electrolytes. This allows us to assume a non-DLVO stabilizing factor in the hydrosols. Accordingly, a new estimate of the Hamaker constant of fullerene–fullerene interaction is proposed. In DMSO and DMF, the coagulation of fullerene sols is hindered due to strong solvation with these basic solvents.

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“…Among the carbon-based nanomaterials, fullerene C 60 (refers to C 60 hereafter), with a stable cage-like structure resistant to the actions of both acids and bases, is a promising material in various fields of biomedicine [ 11 , 12 , 13 , 14 ]. However, C 60 is a fully hydrophobic molecule and has poor solubility in water, which greatly limits its biomedical functions.…”

Section: Introductionmentioning

confidence: 99%

Water-Soluble, Alanine-Modified Fullerene C60 Promotes the Proliferation and Neuronal Differentiation of Neural Stem Cells

Ren

Peng

et al. 2022

IJMS

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As carbon-based nanomaterials, water-soluble C60 derivatives have potential applications in various fields of biomedicine. In this study, a water-soluble fullerene C60 derivative bearing alanine residues (Ala-C60) was synthesized. The effects of Ala-C60 on neural stem cells (NSCs) as seed cells were explored. Ala-C60 can promote the proliferation of NSCs, induce NSCs to differentiate into neurons, and inhibit the migration of NSCs. Most importantly, the Ala-C60 can significantly increase the cell viability of NSCs treated with hydrogen peroxide (H2O2). The glutathioneperoxidase (GSH-Px) and superoxide dismutase (SOD) activities and glutathione (GSH) content increased significantly in NSCs treated even by 20 μM Ala-C60. These findings strongly indicate that Ala-C60 has high potential to be applied as a scaffold with NSCs for regeneration in nerve tissue engineering for diseases related to the nervous system.

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Physicochemical properties, biological activity and biocompatibility of water-soluble C60-Hyp adduct

Cited by 14 publications

References 33 publications

Atranorin is a novel potential candidate drug for treating myelodysplastic syndrome

Atranorin is a novel potential candidate drug for treating myelodysplastic syndrome

Colloid Chemistry of Fullerene Solutions: Aggregation and Coagulation

Water-Soluble, Alanine-Modified Fullerene C60 Promotes the Proliferation and Neuronal Differentiation of Neural Stem Cells

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