Physicochemical properties, antioxidant activities and α-glucosidase inhibitory effects of polysaccharides from Evodiae fructus extracted by different solvents

Xiong, Gaoyin; Ma, Lan; Zhang, Han; Li, Yanping; Zou, Wanshuang; Wang, Xiaofan; Xu, Quansheng; Xiong, Jingteng; Yanping, Hu; Wang, Xiaoyin

doi:10.1016/j.ijbiomac.2021.11.092

Cited by 29 publications

(18 citation statements)

References 64 publications

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“…The Pearson correlation is a more commonly used method for calculating correlation coefficients. It is one of the most fundamental approaches for revealing the direction and degree of linear correlation between two variables, and this correlation analysis technique has been used to explore the structure and bioactivity relationships of polysaccharides in recent years [ 47 , 48 , 49 ]. The correlation between the monosaccharide composition, molecular weight and anti-complementary activity of CMPs was analyzed, and the results and visualizations are shown in Table 3 and Figure 10 .…”

Section: Resultsmentioning

confidence: 99%

Preparation, Characterization and Anti-Complementary Activity of Three Novel Polysaccharides from Cordyceps militaris

Wang

Jin

et al. 2022

Polymers

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This investigation focuses on the three novel polysaccharides from Cordyceps militaris and then discusses their characterization and anti-complementary activity. The three polysaccharides from C. militaris (CMP-1, CMP-2 and CMP-3) were prepared using a DEAE-52 cellulose column. The HPLC, HPGPC, FT-IR and Congo red analyses were used to characterize their monosaccharides, molecular weight and stereo conformation, which demonstrated that the three polysaccharides were homogenous polysaccharides with different molecular weights and were composed of at least ten monosaccharides with different molar ratios, and all had a triple-helix conformation. The evaluation of anti-complementary activity demonstrated that the three polysaccharides significantly inhibited complement activation through the classical pathway and alternative pathway. Preliminary mechanism studies indicated that CMP-1, CMP-2 and CMP-3 acted with C2, C5, C9, factor B, factor B, and P components in the overactivation cascade of the complement system. The analysis of the Pearson correlation and network confirmed that the ribose, glucuronic acid and galacturonic acid composition were negatively correlated with the anti-complementary activity of polysaccharides. These results suggested that the three novel polysaccharides are potential candidates for anti-complementary drugs.

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Section: Resultsmentioning

confidence: 99%

Preparation, Characterization and Anti-Complementary Activity of Three Novel Polysaccharides from Cordyceps militaris

Wang

Jin

et al. 2022

Polymers

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“…In the detection process, the samples were gradiently eluted with A (0.1 mol/L NaOH) and B (0.1 mol/L NaOH and 0.2 mol/L NaAc), which were used as the mobile phases at a flow rate of 0.5 ml/min, and the column temperature was maintained at 30 °C. The conditions of A and B used in the gradient elution process were referred to the previous study (Xiong et al, 2022). At the same time, the mixtures of monosaccharide standards with different concentrations were eluted to build up the calibration curves.…”

Section: Methodsmentioning

confidence: 99%

Comparative study on physicochemical characteristics, α‐glucosidase inhibitory effect, and hypoglycemic activity of pectins from normal and Huanglongbing‐infected navel orange peels

Liang

et al. 2022

Journal of Food Biochemistry

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This study aimed at comparing the physicochemical characteristics, α-glucosidase inhibitory effect, and hypoglycemic activity of pectins (N-NOP and H-NOP) from peels of normal and Huanglongbing (HLB)-infected Navel oranges. Results indicated the pectins were high methoxy pectins mainly composed of homogalacturonan and rhamnogalacturonan-I. The pectins exhibited similar functional groups, surface morphology, and particle size, and had no triple-helical conformation in solution. They

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“…The flower methanolic extract fractionation with ethyl acetate solvent yield in two flavonoid compounds with luteolin showed the highest α-glucosidase activity than 2-(3,4-dihydroxy phenyl)-5,7-dihydroxy-3-methoxy-4H-chromen-4-on compared to the positive control. Polysaccharides extracted from the water extract of Evodiae fructus , a Chinese medicinal herb, show promising α-glucosidase inhibition activity [ 88 ]. The polar extracts of Oryza sativa L (black rice) bran possess potent α-glucosidase inhibitory activity [ 89 ].…”

Section: Plant Extracts As α-Glucosidase Inhibitor Sourcesmentioning

confidence: 99%

“…Recent evidence from the literature revealed that polysaccharides from different plant species could inhibit α-glucosidase activity [ 88 , 122 , 151 ]. A polysaccharide fraction, AXA-1, isolated from wheat bran showed a potential non-competitive mode of inhibitory effects against the α-glucosidase enzyme [ 123 ].…”

Section: Plant-derived Bioactive Compounds As Potential α-Glucosidase...mentioning

confidence: 99%

Recent Updates on Phytoconstituent Alpha-Glucosidase Inhibitors: An Approach towards the Treatment of Type Two Diabetes

Kashtoh

Baek

2022

Plants

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Diabetes is a common metabolic disorder marked by unusually high plasma glucose levels, which can lead to serious consequences such as retinopathy, diabetic neuropathy and cardiovascular disease. One of the most efficient ways to reduce postprandial hyperglycemia (PPHG) in diabetes mellitus, especially insulin-independent diabetes mellitus, is to lower the amount of glucose that is absorbed by inhibiting carbohydrate hydrolyzing enzymes in the digestive system, such as α-glucosidase and α-amylase. α-Glucosidase is a crucial enzyme that catalyzes the final stage of carbohydrate digestion. As a result, α-glucosidase inhibitors can slow D-glucose release from complex carbohydrates and delay glucose absorption, resulting in lower postprandial plasma glucose levels and control of PPHG. Many attempts have been made in recent years to uncover efficient α-glucosidase inhibitors from natural sources to build a physiologic functional diet or lead compound for diabetes treatment. Many phytoconstituent α-glucosidase inhibitors have been identified from plants, including alkaloids, flavonoids, anthocyanins, terpenoids, phenolic compounds, glycosides and others. The current review focuses on the most recent updates on different traditional/medicinal plant extracts and isolated compounds’ biological activity that can help in the development of potent therapeutic medications with greater efficacy and safety for the treatment of type 2 diabetes or to avoid PPHG. For this purpose, we provide a summary of the latest scientific literature findings on plant extracts as well as plant-derived bioactive compounds as potential α-glucosidase inhibitors with hypoglycemic effects. Moreover, the review elucidates structural insights of the key drug target, α-glucosidase enzymes, and its interaction with different inhibitors.

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Physicochemical properties, antioxidant activities and α-glucosidase inhibitory effects of polysaccharides from Evodiae fructus extracted by different solvents

Cited by 29 publications

References 64 publications

Preparation, Characterization and Anti-Complementary Activity of Three Novel Polysaccharides from Cordyceps militaris

Preparation, Characterization and Anti-Complementary Activity of Three Novel Polysaccharides from Cordyceps militaris

Comparative study on physicochemical characteristics, α‐glucosidase inhibitory effect, and hypoglycemic activity of pectins from normal and Huanglongbing‐infected navel orange peels

Recent Updates on Phytoconstituent Alpha-Glucosidase Inhibitors: An Approach towards the Treatment of Type Two Diabetes

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