Physicochemical properties and skin permeation of Span 60/Tween 60 niosomes of ellagic acid

Junyaprasert, Varaporn Buraphacheep; Singhsa, Pratyawadee; Suksiriworapong, Jiraphong; Chantasart, Doungdaw

doi:10.1016/j.ijpharm.2011.11.032

Cited by 189 publications

(93 citation statements)

References 32 publications

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“…This is supported by the broad size distribution in Figures 2 (a1-c2), where diameter of niosomes from Formulation 2 before sonication reached 77.36 μm. Similar results were reported for ellagic acid niosomes (Junyaprasert et al 2012) and paclitaxel niosomes (Bayindir & Yuksel 2010), where the sizes of niosomes increased when the HLB values of the surfactant decreased. The higher amount of Span 80 in Formulation 2 and 4 caused the increase in hydrophobicity which in turn decreases the surface free energy (Akhilesh et al 2012).…”

Section: Resultssupporting

confidence: 85%

Size and Stability of Curcumin Niosomes from Combinations of Tween 80 and Span 80

Nadzir¹,

Tan²,

Mohamed³

et al. 2017

JSM

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Section: Resultssupporting

confidence: 85%

Size and Stability of Curcumin Niosomes from Combinations of Tween 80 and Span 80

Nadzir¹,

Tan²,

Mohamed³

et al. 2017

JSM

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“…In vitro and in vivo studies have confirmed that smaller sized niosomes are better able to retain a bioactive compound at the target site, regardless of the administration route. 128,129 Some bioactive compounds encapsulated in nanoniosomes have beneficial activities, including antioxidant, antimalarial, antifungal, and anti-Alzheimer's disease. 126,130 Nanoniosomes are frequently used to deliver bioactive compounds to the central nervous system with high efficiency and bioactivity.…”

Section: 109mentioning

confidence: 99%

“…Ellagic acid-loaded nanoniosomes have been developed for optimal delivery of bioactive compounds to human dermal cells. 129 Synthetic compounds with diameters of 200 nm, such as doxorubicin, have been developed using the nanoniosome technique. 124 Similarly, nanosized ganciclovir niosomes were developed to enhance bioavailability of ganciclovir in plasma for at least 8 hours after administration.…”

Section: 109mentioning

confidence: 99%

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Ganesan¹,

Ko²,

Kim³

et al. 2015

IJN

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Oxidative stress plays a very critical role in neurodegenerative diseases, such as Parkinson’s disease (PD), which is the second most common neurodegenerative disease among elderly people worldwide. Increasing evidence has suggested that phytobioactive compounds show enhanced benefits in cell and animal models of PD. Curcumin, resveratrol, ginsenosides, quercetin, and catechin are phyto-derived bioactive compounds with important roles in the prevention and treatment of PD. However, in vivo studies suggest that their concentrations are very low to cross blood–brain barrier thereby it limits bioavailability, stability, and dissolution at target sites in the brain. To overcome these problems, nanophytomedicine with the controlled size of 1–100 nm is used to maximize efficiency in the treatment of PD. Nanosizing of phytobioactive compounds enhances the permeability into the brain with maximized efficiency and stability. Several nanodelivery techniques, including solid lipid nanoparticles, nanostructured lipid carriers, nanoliposomes, and nanoniosomes can be used for controlled delivery of nanobioactive compounds to brain. Nanocompounds, such as ginsenosides (19.9 nm) synthesized using a nanoemulsion technique, showed enhanced bioavailability in the rat brain. Here, we discuss the most recent trends and applications in PD, including 1) the role of phytobioactive compounds in reducing oxidative stress and their bioavailability; 2) the role of nanotechnology in reducing oxidative stress during PD; 3) nanodelivery systems; and 4) various nanophytobioactive compounds and their role in PD.

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“…Moreover, it has been reported in several studies, that compared to conventional dosage forms, lipid vesicular formulations exhibited an enhanced drug bioavailability (Manconi et al, 2006;Mura et al, 2007;Shumilov & Touitou, 2010;Imam et al, 2013;Vitorino et al, 2013). Particular efforts have been aimed at using niosomes as effective dermal and transdermal drug delivery systems (Aboelwafa et al, 2010;El-Laithy et al, 2011;Muzzalupo et al, 2011;Junyaprasert et al, 2012;Imam et al, 2013). Pioglitazone (PZ) is a thiazolidinedione derivative with structural formula 5-[4-[2-(5-Ethyl-2-pyridinyl) ethoxy] benzyl] thiazolidine-2,4-dione (Reginato & Lazar, 1999;Waugh et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

QbD-based carbopol transgel formulation: characterization, pharmacokinetic assessment and therapeutic efficacy in diabetes

et al. 2014

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In order to develop transdermal drug delivery system that facilitates the skin permeation of Pioglitazone (PZ) encapsulated in carbopol-based transgel system (proniosomes/niosome). The developed formulations were optimized using quality by design (QbD) approach and particle size, percentage entrapment and transdermal flux were determined. It was found to be more efficient delivery carriers with high encapsulation and enhanced flux value demonstrated that the permeation of PZ through skin was significantly increased with developed formulation. The transdermal enhancement from proniosome was 3.16 times higher than that of PZ from control formulation (ethanol buffer formulation, 3:7), which was further confirmed by confocal laser scanning microscopy. In vivo pharmacokinetic study of carbopol transgel showed a significant increase in bioavailability (2.26 times) compared with tablet formulation. It also showed better antidiabetic activity in comparison to marketed tablet, so our results suggest that carbopol-based transgel are an efficient carrier for delivery of pioglitazone through skin.

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Physicochemical properties and skin permeation of Span 60/Tween 60 niosomes of ellagic acid

Cited by 189 publications

References 32 publications

Size and Stability of Curcumin Niosomes from Combinations of Tween 80 and Span 80

Size and Stability of Curcumin Niosomes from Combinations of Tween 80 and Span 80

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

QbD-based carbopol transgel formulation: characterization, pharmacokinetic assessment and therapeutic efficacy in diabetes

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Physicochemical properties and skin permeation of Span 60/Tween 60 niosomes of ellagic acid

Cited by 189 publications

References 32 publications

Size and Stability of Curcumin Niosomes from Combinations of Tween 80 and Span 80

Size and Stability of Curcumin Niosomes from Combinations of Tween 80 and Span 80

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson&rsquo;s disease models

QbD-based carbopol transgel formulation: characterization, pharmacokinetic assessment and therapeutic efficacy in diabetes

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Product

Resources

About

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models