Physicochemical Properties and Methods of Analysis of Vildagliptin (Review)

Polyakova, E. B.; Sabirzyanov, D. R.; Prozorova, N. A.; Foteeva, A. V.

doi:10.1007/s11094-022-02606-1

Cited by 9 publications

(1 citation statement)

References 23 publications

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“…This may be attributed to the ability of the crown ethers to form host-guest (1:1) complexes with a wide variety of cationic species in the empty cavity centre of the ring. Vildagliptin is basic in nature as it contains a secondary amino group with a pKa value of 9.03 [45] and becomes protonated at working pH. It can efficiently be recognized by the crown ether ionophore with the aid of KTCPB; a lipophilic ion exchanger facilitated the incorporation of vildagliptin into the polymeric matrix to react with the ionophore through electrostatic attraction and hydrogen bonding [22].…”

Section: Potentiometric Response Features Of the Studied Cpesmentioning

confidence: 99%

Utilization of a TiO2–CuO Bimetallic/Polyaniline Nanocomposite as a Transducer in a Solid Contact Potentiometric Sensor for the Determination of Vildagliptin

Abdallah,

Ahmed,

Almaghrabi

et al. 2023

Polymers

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Current fundamental electrochemical research shows the potential of utilizing polymeric nanostructured materials as ion-to-electron transducers. In this paper, aniline was polymerized in the presence of TiO2 and CuO nanoparticles to yield a bimetallic/PANI nanocomposite. It was applied as a transducer in a carbon paste electrode for the potentiometric determination of vildagliptin in the presence of 18-crown-6-ether as a recognition element. The electrode’s potentiometric performance was studied according to the IUPAC guidelines. It exhibited a wide linearity range of 1 × 10−2 M to 1 × 10−8 M, remarkable sensitivity (LOD of 4.5 × 10−9 M), and a fast response time of 10 s ± 1.3. The sensor did not show any potential drift due to the absence of the water layer between the carbon paste and the metallic conductor. This endowed the sensor with high stability and a long lifetime, as 137 days passed without the need to change the carbon paste surface. The electrode was utilized for the determination of the concentration of vildagliptin in bulk, pharmaceutical tablets, and human plasma, with average recovery ranging from 97.65% to 100.03%.

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Section: Potentiometric Response Features Of the Studied Cpesmentioning

confidence: 99%

Utilization of a TiO2–CuO Bimetallic/Polyaniline Nanocomposite as a Transducer in a Solid Contact Potentiometric Sensor for the Determination of Vildagliptin

Abdallah,

Ahmed,

Almaghrabi

et al. 2023

Polymers

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Addressing stability issues of vildagliptin: Method optimization and validation for accurate analysis in human plasma

Tawari,

Shah

2024

Biomedical Chromatography

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This research paper introduces novel strategies to address the stability issues arising with vildagliptin, marking the first attempt to tackle this challenge comprehensively. The study incorporates malic acid into the human plasma, a crucial step in stabilizing vildagliptin and preventing its degradation. Additionally, optimization of the elution process on a C18 Asentis Express column, fine‐tuned with a combination of acetonitrile and ammonium trifluoroacetate 5mM, ensures optimal chromatographic conditions. For detection and quantification, electrospray ionization (ESI) is employed, monitoring multiple reactions for vildagliptin (304.2 → 154.2) and vildagliptin D7 (311.1 → 161.2). Meticulous validation of the method demonstrates high accuracy (97.30%–104.15%) and precision [(0.32%–3.09% coefficient of variance (CV)] for vildagliptin calibration curve standards (CC STD), establishing its sensitivity and reliability in measuring vildagliptin levels. This refined methodology offers numerous advantages, including the elimination of stability concerns, reduced human plasma sample volume (100 μL), exceptional reproducibility, shortened run time (~2.2 min), and a wide concentration range (1.00 to 851.81 ng/mL). These attributes make it exceptionally well‐suited for diverse research applications, spanning from extensive sampling in therapeutic drug monitoring units to bioequivalence and bioavailability studies, as well as pharmacokinetic investigations of vildagliptin.

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Simultaneous determination of enantiomeric and organic impurities of vildagliptin on a cellulose tris(3-chloro-4-methylphenylcarbamate) column under revered-phase conditions

Papp

Hancu

Szabó

2023

Journal of Pharmaceutical and Biomedical Analysis

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Physicochemical Properties and Methods of Analysis of Vildagliptin (Review)

Cited by 9 publications

References 23 publications

Utilization of a TiO2–CuO Bimetallic/Polyaniline Nanocomposite as a Transducer in a Solid Contact Potentiometric Sensor for the Determination of Vildagliptin

Utilization of a TiO2–CuO Bimetallic/Polyaniline Nanocomposite as a Transducer in a Solid Contact Potentiometric Sensor for the Determination of Vildagliptin

Addressing stability issues of vildagliptin: Method optimization and validation for accurate analysis in human plasma

Simultaneous determination of enantiomeric and organic impurities of vildagliptin on a cellulose tris(3-chloro-4-methylphenylcarbamate) column under revered-phase conditions

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