Physicochemical properties and fungicidal activity of inclusion complexes of fungicide chlorothalonil with β-cyclodextrin and hydroxypropyl-β-cyclodextrin

Gao, Shuang; Liu, Yanyan; Jiang, Jingyu; Ji, Qiuyu; Fu, Ying; Zhao, Li‐Xia; Li, Chunyan; Ye, Fei

doi:10.1016/j.molliq.2019.111513

Cited by 76 publications

(43 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At ca. 1,700 cm −1 frequency, the characteristic peak of GA basically disappears, it might be attributed to that GA molecules were encapsulated into the cavity of cyclodextrin by hydrophobic force, hydrogen bonds and other secondary bonds, and restrained by the cavity 34 . The shape of the curve (d) is basically consistent with the shape of the curve (a) peak.…”

Section: Resultsmentioning

confidence: 98%

Study on the preparation of geranyl acetone and β-cyclodextrin inclusion complex and its application in cigarette flavoring

Du¹,

Pan²,

Ji³

et al. 2020

Sci Rep

View full text Add to dashboard Cite

β-Cyclodextrin (β-CD) inclusion complex containing geranyl acetone as a guest was prepared by saturated water solution method. Furthermore, the structure and properties of the inclusion complex were studied. The formation of the inclusion complex was demonstrated by. Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (X-RD), thermogravimetric analysis (TG) and differential scanning calorimetry (DSC). The thermodynamic analysis of the inclusion complex showed that the inclusion reaction is an endothermic spontaneous reaction. The average of △H, △S and △G is 11.66 kJ mol −1 , 0.082 kJ mol −1 and − 14.49 kJ mol −1 , respectively. Moreover, the kinetic analysis of thermal decomposition of the inclusion compound showed that the thermal decomposition reaction is a first-order reaction (the inclusion ratio is 1:1), the average activation energy of the reaction is 180.90 kJ mol −1 , and the binding force in the inclusion compound is mainly Van der Waals force. The flavor test of cigarettes showed that the inclusion compound improved the stability of geranyl acetone and the sensory quality of cigarettes. This study improves the solubility and thermal stability of geranyl acetone, and provides theoretical support and technical guidance for expanding the application of geranyl acetone.

show abstract

Section: Resultsmentioning

confidence: 98%

Study on the preparation of geranyl acetone and β-cyclodextrin inclusion complex and its application in cigarette flavoring

Du¹,

Pan²,

Ji³

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Molecular modelling was performed to study the complexation between host molecules and guest molecules. 28,29 The molecular model in Fig. 9 was the lowest energy model obtained by molecular modelling.…”

Section: Results Of Molecular Modellingmentioning

confidence: 99%

Preparation and characterization of cyanazine–hydroxypropyl-beta-cyclodextrin inclusion complex

Gao

Bie

et al. 2019

RSC Adv.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The novel advances in MIT have resulted in the appearance of synthetically engineered MIPs incorporated with cyclodextrins (CDs) in an imprinted polymeric framework with the improved performance [ 123 , 124 , 125 ]. CDs are cyclic oligosaccharide structures established by d -glucopyranose units consist of 6 (α-CD), 7 (β-CD) and 8 (γ-CD) d -Glucose Monomer, that are linked by glycosidic bonds [ 126 ]. The glucose units of CD with a non-twisted chair arrangement conform a narrow half-tapered cavity structure of CD [ 127 ].…”

Section: Magnetic Molecularly Imprinted Polymer (Mmip) Preparationmentioning

confidence: 99%

“…Therefore, hydrophobic drugs can entirely or partially enter within these lipophilic cavities, and a CD-drug complex is formed by host–guest non-covalent bindings. Hence, CDs potentially can improve the problem with the solubility of hydrophobic poorly soluble drugs in aqueous media through encapsulation of such guest compounds into their cavities when they can match with cavities in terms of polarity, size, shape and properties [ 126 , 129 ]. Formation of a stable supermolecular complex between CDs and larger guest structures is also possible through their hydrophobic groups, which can bind into these CDs cavities [ 126 , 129 ].…”

Section: Magnetic Molecularly Imprinted Polymer (Mmip) Preparationmentioning

confidence: 99%

Developments of Smart Drug-Delivery Systems Based on Magnetic Molecularly Imprinted Polymers for Targeted Cancer Therapy: A Short Review

Sanadgol

Wackerlig

2020

Pharmaceutics

View full text Add to dashboard Cite

Cancer therapy is still a huge challenge, as especially chemotherapy shows several drawbacks like low specificity to tumor cells, rapid elimination of drugs, high toxicity and lack of aqueous solubility. The combination of molecular imprinting technology with magnetic nanoparticles provides a new class of smart hybrids, i.e., magnetic molecularly imprinted polymers (MMIPs) to overcome limitations in current cancer therapy. The application of these complexes is gaining more interest in therapy, due to their favorable properties, namely, the ability to be guided and to generate slight hyperthermia with an appropriate external magnetic field, alongside the high selectivity and loading capacity of imprinted polymers toward a template molecule. In cancer therapy, using the MMIPs as smart-drug-delivery robots can be a promising alternative to conventional direct administered chemotherapy, aiming to enhance drug accumulation/penetration into the tumors while fewer side effects on the other organs. Overview: In this review, we state the necessity of further studies to translate the anticancer drug-delivery systems into clinical applications with high efficiency. This work relates to the latest state of MMIPs as smart-drug-delivery systems aiming to be used in chemotherapy. The application of computational modeling toward selecting the optimum imprinting interaction partners is stated. The preparation methods employed in these works are summarized and their attainment in drug-loading capacity, release behavior and cytotoxicity toward cancer cells in the manner of in vitro and in vivo studies are stated. As an essential issue toward the development of a body-friendly system, the biocompatibility and toxicity of the developed drug-delivery systems are discussed. We conclude with the promising perspectives in this emerging field. Areas covered: Last ten years of publications (till June 2020) in magnetic molecularly imprinted polymeric nanoparticles for application as smart-drug-delivery systems in chemotherapy.

show abstract

Physicochemical properties and fungicidal activity of inclusion complexes of fungicide chlorothalonil with β-cyclodextrin and hydroxypropyl-β-cyclodextrin

Cited by 76 publications

References 36 publications

Study on the preparation of geranyl acetone and β-cyclodextrin inclusion complex and its application in cigarette flavoring

Study on the preparation of geranyl acetone and β-cyclodextrin inclusion complex and its application in cigarette flavoring

Preparation and characterization of cyanazine–hydroxypropyl-beta-cyclodextrin inclusion complex

Developments of Smart Drug-Delivery Systems Based on Magnetic Molecularly Imprinted Polymers for Targeted Cancer Therapy: A Short Review

Contact Info

Product

Resources

About