Physicochemical Interactions of Chlorpheniramine Maleate with Sodium Deoxycholate in Aqueous Solution

Abstract

The present study investigated the interactions of sodium deoxycholate (SDC) and chlorpheniramine maleate (CPM) in aqueous solution to help develop alternative pharmaceutical formulations. Surface tension measurements were used to characterize mixed aggregate formation of CPM‐SDC. The mixed system showed a large turbid region between αCPM = 0.3 and 0.9. The theoretical approaches of Clint, Rubingh, and Rosen were used to determine the nature of the interactions between CPM and SDC in the bulk as well as at the interface. Negative interaction parameter (−β m) values indicated strong attractive interactions between CPM and SDC mixed solution. The ΔG oex values for all CPM‐SDC systems were found to be negative and energetically favorable for micellization as well as adsorption processes. The dynamic light scattering results have demonstrated the size (d H) of CPM‐SDC aggregates in the composition from αCPM = 0.0 to 1.0. In the middle composition αCPM = 0.5, very large‐sized aggregates were formed.

Concentration Dependent Single Chain Properties of Poly(sodium 4-styrenesulfonate) Subjected to Aromatic Interactions with Chlorpheniramine Maleate Studied by Diafiltration and Synchrotron-SAXS

“…Short-range aromatic-aromatic interaction with the drug CPM should influence the size and mobility of the PSS segments. The thermal blobs, involving a higher number of unhydrated ion pairs stabilized in hydrophobic domains as the concentration increases, grow, and it is probable that they form clusters due to a certain tendency of CPM to self-aggregate [ 80 ]. These facts may be responsible for the increase in the thermal blob size, which further triggers an increase in the swollen fractal blobs size.…”

Binding and occupancy properties of gabapentin in mixed surfactant systems

“…These synergistic effects include increased wetting, detergency, solubilization, and surface activity. In equilibrium with the surfactant monomers, mixed micellar aggregates are made up of two or more distinct surfactants (Azum et al, 2019; Azum et al, 2023; Kumar et al, 2022; Kumar, Raj, et al, 2021; Kumar, Singh, et al, 2021; Mahajan & Mahajan, 2012; Srivastava et al, 2015; Srivastava, Liu, et al, 2018; Srivastava, Qiao, & Ismail, 2018; Srivastava, Thapa, et al, 2019; Srivastava, Uchiyama, et al, 2019; Uchiyama et al, 2018; Vashishat et al, 2015).…”