Abstract:As microemulsões, quando usadas como fase móvel, representam uma ferramenta cromatográfica poderosa devido à sua estrutura polifásica. O objetivo deste estudo foi investigar a influência da composição da fase móvel e as propriedades das gotículas resultantes da microemulsão, bem como a lipofilicidade da fase estacionária no comportamento cromatográfico de pramipexol e suas cinco impurezas. A investigação foi realizada de acordo com o plano experimental definido pelo planejamento fatorial completo 2 4 com quatr… Show more
“…Some of them originate from the manufacturing process of the active pharmaceutical ingredient (API). Others may be caused by oxidation or degradation of pramipexole in the process of preparation and storage . For instance, Nishimura et al reported that 5 might be caused by photodegradation of pramipexole in the preparation and explained possible mechanisms for this in the solid state and the liquid state.…”
Three impurities of pramipexole dihydrochloride were synthesized, and the possible generation mechanisms and the preparation methods of some impurities were reviewed. The desired configuration at C7 of 3 was built by a Mitsunobu reaction.
“…Some of them originate from the manufacturing process of the active pharmaceutical ingredient (API). Others may be caused by oxidation or degradation of pramipexole in the process of preparation and storage . For instance, Nishimura et al reported that 5 might be caused by photodegradation of pramipexole in the preparation and explained possible mechanisms for this in the solid state and the liquid state.…”
Three impurities of pramipexole dihydrochloride were synthesized, and the possible generation mechanisms and the preparation methods of some impurities were reviewed. The desired configuration at C7 of 3 was built by a Mitsunobu reaction.
“…So far pramipexole and its impurities have been analyzed in different liquid chromatographic systems [22][23][24][25][26], but this is the first time in literature that this approach is suggested.…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.