Physicochemical fabrication of calcium phosphate-based thin layers and nanospheres using laser processing in solutions

Nakamura, Minoru; Oyane, Ayako

doi:10.1039/c6tb01362g

Cited by 23 publications

(17 citation statements)

References 97 publications

(173 reference statements)

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“…Conventional biomimetic processes are weak in productivity, which require a fairly long processing period (more than a day) because of multi-step procedures and slow CaP growth rate in the immersion step. Recently, we combined a laser process with a biomimetic process to achieve facile single-step CaP coatings on several artificial materials [ 24 – 28 ] by refining earlier techniques proposed by Pecheva et al . [ 29 ] and Lee et al .…”

Section: Introductionmentioning

confidence: 99%

“…The aim of this study is to apply the LAB process for CaP coating to PEEK substrates and to demonstrate the improved biological properties of the resulting material. The LAB process has been applied to several artificial materials with laser absorption [ 24 – 28 ]. However, its applicability to chemically unreactive PEEK remains to be clarified.…”

Section: Introductionmentioning

confidence: 99%

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Laser-assisted wet coating of calcium phosphate for surface-functionalization of PEEK

et al. 2018

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Calcium phosphate (CaP) coating is an effective method for surface-functionalization of bioinert materials and for production of osteoconductive implants. Recently, we developed a laser-assisted biomimetic process (LAB process) for facile and area-specific CaP coating. In this study, the LAB process was applied to chemically stable and mechanically durable poly(etheretherketone) (PEEK), which has become widely used as an orthopedic and dental implant material. The LAB process was carried out by irradiating pulsed Nd:YAG laser light (355 nm) onto a PEEK substrate that was immersed in supersaturated CaP solution. The CaP coating applicability depended on laser fluence, i.e., CaP successfully formed on PEEK surface after the LAB process at 2 W/cm2. Further increase in laser fluence did not result in the successful formation. At the optimal fluence of 2 W/cm2, the laser-irradiated PEEK surface was modified and heated to induce heterogeneous CaP precipitation within 10 min in CaP solution, followed by further CaP growth over the irradiation time (tested up to 30 min). The LAB process improved the cytocompatibility of PEEK surface with osteoblastic MC3T3-E1 cells. Furthermore, the LAB-processed CaP-coated PEEK substrate formed a dense hydroxyapatite layer on its surface in the simulated body fluid, suggesting the osteoconductivity of this material. The present LAB process can be a useful new tool to produce osteoconductive PEEK-based implants.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Laser-assisted wet coating of calcium phosphate for surface-functionalization of PEEK

et al. 2018

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“…Ansar et al reported one-pot fabrication of IO-loaded CaP particles, however, their processing time was as long as a day [17]. We recently developed a facile one-pot fabrication process of CaP-based submicrospheres containing IO nanoparticles (denoted by IO-CaP submicrospheres) using a laser-assisted precipitation process (Figure 1a) [18,19]. In this process, weak pulsed laser irradiation was applied to a pH-controlled labile CaP reaction mixture (a mixture of calcium and phosphate ion solutions) supplemented with ferrous ions (Fe 2+ ).…”

Section: Introductionmentioning

confidence: 99%

Structural Analysis of Calcium Phosphate-Based Submicrospheres with Internally-Crystallized Iron Oxide Nanoparticles Fabricated by a Laser-Assisted Precipitation Process

Nakamura

Oyane

2019

Materials

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Calcium phosphate (CaP)-based submicrospheres containing magnetic iron oxide (IO) nanoparticles (IO–CaP submicrospheres) have potential for various biomedical applications. We recently achieved facile one-pot fabrication of IO–CaP submicrospheres using a laser-assisted precipitation process in which weak pulsed laser irradiation was applied to a labile CaP reaction mixture supplemented with ferrous ions under adequate pH. In this study, we performed cross-sectional transmission electron microscopy (TEM) analysis of the resulting IO–CaP submicrospheres. The cross-sectional TEM analysis revealed that the IO–CaP submicrospheres were heterogeneous in their internal nanostructures and could be categorized into two types, namely types A and B. The type A submicrospheres contained single nano-sized IO nanoparticles homogeneously dispersed throughout the CaP-based matrix. The type B submicrospheres contained larger IO nanoparticles with an irregular or spherical shape, which were mostly a few tens of nanometers in size along with one or two submicron-sized domains. These findings provide new insight into the formation mechanism of IO–CaP submicrospheres in this fabrication technique as well as future applications of the resulting IO–CaP submicrospheres.

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“…Furthermore, the coating medium should contain no harmful components and must be intraorally administrable. Recently, the authors developed a CaP coating technique using a laser-assisted biomimetic (LAB) process that satisfies these requirements [ 11 , 12 , 13 , 14 , 15 , 16 ]. In the LAB process, a weak pulsed Nd:YAG laser is used to irradiate the target region of an artificial material immersed in a supersaturated CaP solution.…”

Section: Introductionmentioning

confidence: 99%

Calcium phosphate coating on dental composite resins by a laser-assisted biomimetic process

Nathanael

Oyane

Nakamura

et al. 2018

Heliyon

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ObjectivesDental composite resins with better biocompatibility and osteoconductivity have been sought in endodontic treatments. This study aimed to develop a technique to produce the osteoconductive resin surfaces through calcium phosphate (CaP) coating using a laser-assisted biomimetic (LAB) process.MethodsLight-cured, acrylic-based composite resins were used as substrates. The resin substrate was subjected to a LAB process comprising Nd:YAG pulsed laser irradiation in a supersaturated CaP solution. The LAB-processed substrate was immersed for 3 days in a simulated body fluid (SBF) for the preliminary osteoconductivity assessment.ResultsAfter irradiation for 30 min, the resin surfaces were partly coated with a newly formed CaP layer. The coating layer contained hydroxyapatite as the main crystalline phase and the coating coverage depended on the laser wavelength and the type of resin. The LAB-processed CaP-coated surface exhibited apatite-forming ability in SBF.ConclusionsLAB process is effective for CaP coating on light-cured dental composite resins and improving their osteoconductivity.Clinical significanceThe LAB process is a potential new tool to create a cementum-like osteoconductive surface on dental composite resins.

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Physicochemical fabrication of calcium phosphate-based thin layers and nanospheres using laser processing in solutions

Abstract: We achieved simple and rapid fabrication of calcium phosphate (CaP)-based thin layers and nanospheres by laser processing in supersaturated solutions.

Cited by 23 publications

References 97 publications

Laser-assisted wet coating of calcium phosphate for surface-functionalization of PEEK

Laser-assisted wet coating of calcium phosphate for surface-functionalization of PEEK

Structural Analysis of Calcium Phosphate-Based Submicrospheres with Internally-Crystallized Iron Oxide Nanoparticles Fabricated by a Laser-Assisted Precipitation Process

Calcium phosphate coating on dental composite resins by a laser-assisted biomimetic process

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