2023
DOI: 10.1002/adpr.202300036
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Physicochemical Descriptors in Biodistribution and Clearance of Contrast Agents

Sung Ahn,
Benjamin Sanchez-Langeling,
Jeong Heon Lee
et al.

Abstract: Hepatobiliary and renal excretions are the two major in vivo elimination pathways, of which prediction is particularly important for the optimization of systemic and/or target‐site exposure of new near‐infrared (NIR) fluorescent contrast agents. To characterize the physicochemical descriptors associated with each clearance route, a compound library containing more than 760 NIR fluorophores is analyzed and systematically reviewed in this study. Although there are a host of biochemical and physiological mechanis… Show more

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