Physicochemical compatibility studies of triclosan and flurbiprofen with excipients of pharmaceutical formulation using binary, ternary, and multi-combination approach

Abstract

Background The aim of the study was to evaluate the suitability of triclosan (TCS) and flurbiprofen (FLB) with poly-ε-caprolactone (PCL), chitosan (CS), and Kolliphor® P188 (KP) for possible application in the design of nano-formulations. Results Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), and scanning electron microscopy (SEM) revealed the physical characteristics of the various sample compositions without any apparent interaction. The Fourier transform infrared spectroscopy (FTIR)’s spectra of the physical mixtures showed their characteristic absorption bands with broadening and overlapping of bands in some instances, but no appearance of new bands was observed. Conclusion The study revealed the physical form stability of the evaluated components after the storage period and lack of definite pharmaceutical incompatibility between them. Thus, the selected drugs and excipients could be used for the development of pharmaceutical nano-formulations.

Application of hydrophilic polymers for the preparation of tadalafil solid dispersions: micromeritics properties, release and erectile dysfunction studies in male rats

“…Kollidon 30 exhibited peaks at 2,957 cm −1 (OH str) and 1,665 cm −1 (CO str). KollidoneVA64 exhibited 2,954 cm −1 (OH str) and 1673 cm −1 (CO str), which are an agreement with reported spectra ( Poudel & Kim, 2021 ; Aminu et al, 2021 ).…”

Acetylation and Physicochemical Properties of Ampelocissus africana (Wild Cassava Tuber) Starch for Enhanced Drug Delivery

“…The FTIR spectra indicated the presence of four major absorption peaks: O-H stretch, C-H stretch, C-O stretch, and C=O stretch vibrations, which absorbed around 3300 cm -1 , 2900 cm -1 , 730 cm -1 , and 1700 cm -1 , respectively. The results were similar to the findings of Aminu et al, 2021 21. Thermogravimetric analysis (TGA)The thermograms for native cassava starch (NCS) and acetylated cassava starch (ACS) are shown in Figures6 and 7, respectively.…”

Peer Review #3 of "Application of hydrophilic polymers for the preparation of tadalafil solid dispersions: micromeritics properties, release and erectile dysfunction studies in male rats (v0.1)"

“…Kollidon 30 exhibited peaks at 2957 cm-1 (OH str) and 1665 cm-1 (CO str). KollidoneVA64 exhibited 2954 cm-1 (OH str) and 1673 cm-1 (CO str), which are an agreement with reported spectra[49,50].426 427 However, the FTIR spectrums of the binary SDs of TFL with Kolliphor® P188 (TK188)/ Kollidon® VA64 (TK64)/ Kollidon® 30 (TK30) is the sum of spectra of drug and polymer dispersions in which the prominent functional bands of the drug with reduced intensities observed. All the spectrums of TFL and SDs presented in Figure 2.…”