Physicochemical characterization of curcuminoid-loaded solid lipid nanoparticles

Noack, Andreas; Hause, Gerd; Mäder, Karsten

doi:10.1016/j.ijpharm.2011.12.011

Cited by 72 publications

(43 citation statements)

References 38 publications

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“…Several factors, including types of lipids and the surfactant concentration, affect the optimal EE of NLCs. 30 The EE of the optimized 5-FU-NLC formulations ranged from 71.45%±2.45% to 86.62%±1.94%, and the results are shown in Table 2. It was noticed that an increase in the concentration of total lipids resulted in increased EE.…”

Section: Particle Size and Pdimentioning

confidence: 98%

“…The HLB values of PRE and LBS are 4.2 and 14, respectively, and these are commonly used in formulations for their surfactant properties. 30 The combination of solid and liquid lipids showing the most promising results (ie, smaller particle size and higher loading of liquid lipid) was around 65:35 of PRE/LBS. The maximum lipid concentrations of both solid and liquid lipids that allow a stable nanodispersion was selected and used for further analysis.…”

Section: Preparation Of 5-fu-nlcmentioning

confidence: 99%

“…The hot homogenization method involves the mixing of the hot oil and the water phase together to form a preemulsion using highspeed stirring, followed by passage through a high-pressure homogenizer at pressure of 1,500 bars to break down the particle into nanosized ones. 29,30 The resultant sample was passed through for 5 cycles in order to obtain particle size ,200 nm with uniform size distribution. It was observed that there was no significant reduction in the particle size of NLCs when the number of cycles was increased further.…”

Section: Preparation Of 5-fu-nlcmentioning

confidence: 99%

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Development and evaluation of nanostructured lipid carrier-based hydrogel for topical delivery of 5-fluorouracil

Rajinikanth¹,

Chellian²

2016

IJN

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The aim of this study was to develop a nanostructured lipid carrier (NLC)-based hydrogel and study its potential for the topical delivery of 5-fluorouracil (5-FU). Precirol ® ATO 5 (glyceryl palmitostearate) and Labrasol ® were selected as the solid and liquid lipid phases, respectively. Poloxamer 188 and Solutol ® HS15 (polyoxyl-15-hydroxystearate) were selected as surfactants. The developed lipid formulations were dispersed in 1% Carbopol ® 934 (poly[acrylic acid]) gel medium in order to maintain the topical application consistency. The average size, zeta potential, and polydispersity index for the 5-FU-NLC were found to be 208.32±8.21 nm, −21.82±0.40 mV, and 0.352±0.060, respectively. Transmission electron microscopy study revealed that 5-FU-NLC was <200 nm in size, with a spherical shape. In vitro drug permeation studies showed a release pattern with initial burst followed by sustained release, and the rate of 5-FU permeation was significantly improved for 5-FU-NLC gel (10.27±1.82 μg/cm 2 /h) as compared with plain 5-FU gel (2.85±1.12 μg/cm 2 /h). Further, skin retention studies showed a significant retention of 5-FU from the NLC gel (91.256±4.56 μg/cm 2 ) as compared with that from the 5-FU plain gel (12.23±3.86 μg/cm 2 ) in the rat skin. Skin irritation was also significantly reduced with 5-FU-NLC gel as compared with 5-FU plain gel. These results show that the prepared 5-FU-loaded NLC has high potential to improve the penetration of 5-FU through the stratum corneum, with enormous retention and with minimal skin irritation, which is the prerequisite for topically applied formulations.

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Section: Particle Size and Pdimentioning

confidence: 98%

Section: Preparation Of 5-fu-nlcmentioning

confidence: 99%

Section: Preparation Of 5-fu-nlcmentioning

confidence: 99%

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Development and evaluation of nanostructured lipid carrier-based hydrogel for topical delivery of 5-fluorouracil

Rajinikanth¹,

Chellian²

2016

IJN

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“…This method involves the mixing of hot oil-in-water emulsion using a stirrer, followed by passage through a HPH device (EmulsiFlex-C3) to break down the particle size. 4,26 The pressure for the HPH was set at 1,500 bar, and the sample was passed through for five cycles. Further increase in the number of cycles did not show any significant reduction in the particle size.…”

Section: Preparation Of Itz-nlcsmentioning

confidence: 99%

Formulation and delivery of itraconazole to the brain using a nanolipid carrier system

Lim¹,

Rajinikanth²,

Chitneni³

et al. 2014

IJN

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The objectives of this study were to develop and characterize itraconazole (ITZ)-loaded nanostructured lipid carriers (NLCs) and to study their potential for drug delivery into the brain. Precirol ® ATO 5 and Transcutol ® HP were selected as the lipid phase, and Tween ® 80 and Solutol ® HS15 as surfactants. The ITZ-NLCs were prepared by a hot and high-pressure homogenization method. The entrapment efficiency for the best formulation batch was analyzed using high-performance liquid chromatography and was found to be 70.5%±0.6%. The average size, zeta potential, and polydispersity index for the ITZ-NLCs used for animal studies were found to be 313.7±15.3 nm, −18.7±0.30 mV, and 0.562±0.070, respectively. Transmission electron microscopy confirmed that ITZ-NLCs were spherical in shape, with a size of less than 200 nm. Differential scanning calorimetry and X-ray diffractometry analysis showed that ITZ was encapsulated in the lipid matrix and present in the amorphous form. The in vitro release study showed that ITZ-NLCs achieved a sustained release, with cumulative release of 80.6%±5.3% up to 24 hours. An in vivo study showed that ITZ-NLCs could increase the ITZ concentration in the brain by almost twofold. These results suggest that ITZ-NLCs can be exploited as nanocarriers to achieve sustained release and brain-targeted delivery.

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“…On the other hand, reports on the use of modified SLNs as a carrier of curcumin are scarce 24 . Hence, the long-term stability of curcumin loaded into modified SLNs and its release are interesting topics of research 21 . Due to the presence of a chromophoric group, curcumin shows strong absorption and emission spectra in the ultraviolet UV -visible region.…”

Section: Selection Of An Appropriate Blend Of Lipids Is Key Tomentioning

confidence: 99%

Effects of Fatty Acids on the Interfacial and Solution Behavior of Mixed Lipidic Aggregates Called Solid Lipid Nanoparticles

et al. 2016

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Physicochemical characterization of curcuminoid-loaded solid lipid nanoparticles

Cited by 72 publications

References 38 publications

Development and evaluation of nanostructured lipid carrier-based hydrogel for topical delivery of 5-fluorouracil

Development and evaluation of nanostructured lipid carrier-based hydrogel for topical delivery of 5-fluorouracil

Formulation and delivery of itraconazole to the brain using a nanolipid carrier system

Effects of Fatty Acids on the Interfacial and Solution Behavior of Mixed Lipidic Aggregates Called Solid Lipid Nanoparticles

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