Physicochemical characterization and thermal behavior of hexosomes containing ketoconazole as potential topical antifungal delivery system

Gazga-Urioste, César; Rivera-Becerril, Ernesto; Pérez-Hernández, Gerardo; Noguez-Méndez, Norma; Faustino-Vega, Abraham; Quirino-Barreda, Carlos Tomás

doi:10.1080/03639045.2018.1526188

Cited by 15 publications

(5 citation statements)

References 19 publications

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“…This effect was specific for formulations 2–4 containing the Brij 72 and symperonic. These results were similar to those previously reported for ketoconazole-loaded lyotropic colloidal liquid crystals [38].…”

Section: Resultssupporting

confidence: 92%

Mathematical Models as Tools to Predict the Release Kinetic of Fluorescein from Lyotropic Colloidal Liquid Crystals

et al. 2019

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In this study, we investigated the release kinetic of fluorescein from colloidal liquid crystals made from monoglyceride and different non-ionic surfactants. The crystals were physicochemically characterized and the release experiments were carried out under the sink conditions, while mathematical models were described as extrapolations from solutions of the diffusion equation, in different initial and boundary conditions imposed by pharmaceutical formulations. The diffusion equation was solved using Laplace and Fourier transformed functions for release kinetics from infinite reservoirs in a semi-infinite medium. Solutions represents a general square root law and can be applied for the release kinetic of fluorescein from lyotropic colloidal liquid crystals. Akaike, Schwartz, and Imbimbo criteria were used to establish the appropriate mathematical model and the hierarchy of the performances of different models applied to the release experiments. The Fisher statistic test was applied to obtain the significance of differences among mathematical models. Differences of mathematical criteria demonstrated that small or no significant statistic differences were carried out between the various applied models and colloidal formulations. Phenomenological models were preferred over the empirical and semi-empirical ones. The general square root model shows that the diffusion-controlled release of fluorescein is the mathematical models extrapolated for lyotropic colloidal liquid crystals.

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Section: Resultssupporting

confidence: 92%

Mathematical Models as Tools to Predict the Release Kinetic of Fluorescein from Lyotropic Colloidal Liquid Crystals

et al. 2019

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“…Additionally, the hexosomes were found to be both physically and chemically stable and exhibited mesophasic thermal reversibility, which make them ideal for SDD. [92] Another study by AlZuhairi et al evaluated the effectiveness of a newly developed petrolatum-LC ointment for SDD. The study assessed the physical and chemical properties of the ointment, as well as its ability to release medication and enhance skin penetration.…”

Section: Lyotropic Crystals Npsmentioning

confidence: 99%

“…Additionally, the hexosomes were found to be both physically and chemically stable and exhibited mesophasic thermal reversibility, which make them ideal for SDD. [ 92 ]…”

Section: Lipid Nanocarriersmentioning

confidence: 99%

Progress in Lipid and Inorganic Nanocarriers for Enhanced Skin Drug Delivery

Albakr,

Du,

Zhang

et al. 2024

Advanced NanoBiomed Research

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New advancements in nanocarrier technologies are revolutionizing the delivery of drugs through the skin, allowing for precise treatment with better absorption, stability, and bioavailability. This review investigates lipid and inorganic nanocarriers like liposomes, ethosomes, and inorganic nanoparticles and assesses their potential for delivering drugs through the skin. It emphasizes the mechanisms that enable controlled release and deeper skin penetration, which are crucial for ensuring effectiveness in clinical applications. The review synthesizes existing research, acknowledging that only few nanocarriers are successfully deployed in clinical settings. By offering a comprehensive overview, it sheds light on the progress and future obstacles to using nanocarriers for drug delivery through the skin.

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“…These lipids are biocompatible, biodegradable, and economical (71)(72)(73). The LCNP-based formulation poses several advantages like controlled drug release, improved stability of the drug, and entrapment of hydrophilic, hydrophobic, and amphiphilic drugs (74,75). The formulation can be easily scaled up and does not use organic solvents (14,76).…”

Section: Liquid Crystal Nanoparticles (Lcnps) For Topical Delivery Of Curcuminmentioning

confidence: 99%

Emerging Trends in Topical Delivery of Curcumin Through Lipid Nanocarriers: Effectiveness in Skin Disorders

et al. 2020

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Curcumin is a unique molecule naturally obtained from rhizomes of Curcuma longa. Curcumin has been reported to act on diverse molecular targets like receptors, enzymes, and co-factors; regulate different cellular signaling pathways; and modulate gene expression. It suppresses expression of main inflammatory mediators like interleukins, tumor necrosis factor, and nuclear factor κB which are involved in the regulation of genes causing inflammation in most skin disorders. The topical delivery of curcumin seems to be more advantageous in providing a localized effect in skin diseases. However, its low aqueous solubility, poor skin permeation, and degradation hinder its application for commercial use despite its enormous potential. Lipid-based nanocarrier systems including liposomes, niosomes, solid lipid nanoparticles, nanostructured lipid carriers, lyotropic liquid crystal nanoparticles, lipospheres, and lipid nanocapsules have found potential as carriers to overcome the issues associated with conventional topical dosage forms. Nano-size, lipophilic nature, viscoelastic properties, and occlusive effect of lipid nanocarriers provide high drug loading, hydration of skin, stability, enhanced permeation through the stratum corneum, and slow release of curcumin in the targeted skin layers. This review particularly focuses on the application of lipid nanocarriers for the topical delivery of curcumin in the treatment of various skin diseases. Furthermore, preclinical studies and patents have also indicated the emerging commercialization potential of curcumin-loaded lipid nanocarriers for effective drug delivery in skin disorders.

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Physicochemical characterization and thermal behavior of hexosomes containing ketoconazole as potential topical antifungal delivery system

Abstract: Physicochemical properties of the hexosomes containing ketoconazole are important for topical mycosis treatment administration, conditions of storage, and for its incorporation into the formulation of semi-solid dosage forms.

Cited by 15 publications

References 19 publications

Mathematical Models as Tools to Predict the Release Kinetic of Fluorescein from Lyotropic Colloidal Liquid Crystals

Mathematical Models as Tools to Predict the Release Kinetic of Fluorescein from Lyotropic Colloidal Liquid Crystals

Progress in Lipid and Inorganic Nanocarriers for Enhanced Skin Drug Delivery

Emerging Trends in Topical Delivery of Curcumin Through Lipid Nanocarriers: Effectiveness in Skin Disorders

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