Physicochemical characterization and cytotoxic studies of nonionic surfactant vesicles using sucrose esters as oral delivery systems

Valdés, Karina; Morilla, María José; Romero, Eder Lilia; Chávez, Jorge

doi:10.1016/j.colsurfb.2014.01.029

Cited by 30 publications

(23 citation statements)

References 50 publications

(60 reference statements)

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“…In the zeta potential analysis, liposomes positively or negatively charged showed values higher than 30 mV (module). According to the literature, it has been reported that a physically stable nanosuspension solely stabilised by electrostatic repulsion has a minimum zeta potential of 30 mV (module) (Di Marzio et al, 2011;Valdés et al, 2014). Therefore, if all particles in suspension have a large negative or positive zeta potential then they will tend to repel each other and will not come together (Mady and Darwish, 2010).…”

Section: Discussionmentioning

confidence: 97%

Cinnamic acid derived compounds loaded into liposomes: antileishmanial activity, production standardisation and characterisation

Cury¹,

Yoneda²,

Zuliani³

et al. 2015

Journal of Microencapsulation

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Synthetic compounds derived from cinnamic acid were tested in cultures containing the promastigote form of Leishmania amazonensis and the dimethylsulphoxide solution of B2 compound (2.0 mg/mL) led to a 92% decrease of leishmania in 96 h of treatment. Then, different liposomal systems (diameters ∼200 nm) were prepared by the extrusion method in the presence and absence of compounds studied. DSC thermograms of the liposomes in the presence of these compounds caused changes in ΔH, Tm and ΔT1/2, compared to controls, indicating that there was an interaction of the compounds with the lipid bilayer. Assays with negatively charged liposomal systems containing these drugs in L. amazonensis cultures led to a 50-80% decrease in the number of leishmanias with a concentration to 100 times lower when compared to the B2 initial test. These liposomal systems are promoting more interaction and delivery of the compounds and proved to be an efficient, stable and promising system.

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Section: Discussionmentioning

confidence: 97%

Cinnamic acid derived compounds loaded into liposomes: antileishmanial activity, production standardisation and characterisation

Cury¹,

Yoneda²,

Zuliani³

et al. 2015

Journal of Microencapsulation

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show abstract

“…Surface active agents have been widely utilized as drug solubilizers. However, safety concerns can be a prohibitive factor towards the development of new surfactant-based delivery systems (Kong et al, 2013;Valdés et al, 2014). Thus, acute toxicity test in animals was conducted to evaluate formulation toxicity in vivo.…”

Section: Acute Toxicity In Vivomentioning

confidence: 99%

“…However, the chemical stability as well as the relatively low cost of the materials used to prepare niosomes may make them more attractive than liposomes for pharmaceutical and cosmetic applications (Hashim et al, 2010;Valdés et al, 2014;Yasam et al, 2014).…”

Section: Introductionmentioning

confidence: 96%

Development of a biocompatible creatinine-based niosomal delivery system for enhanced oral bioavailability of clarithromycin

et al. 2016

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“…Solubilization of drugs in surfactants is extremely important for enhanced therapeutic efficacy, however safety concerns may impose restrictions (Kong et al, 2013;Valdés et al, 2014). To ensure that the drug delivery system is safe and validate the in vitro cytotoxicity and hemo-compatibility results, acute toxicity investigations of BRD-BG were conducted in vivo using mice.…”

Section: In Vivo Acute Toxicitymentioning

confidence: 99%

Sugar-based novel niosomal nanocarrier system for enhanced oral bioavailability of levofloxacin

et al. 2016

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Context: Vesicular systems have attracted great attention in drug delivery because of their amphiphilicity, biodegradability, non-toxicity and potential for increasing drug bioavailability. Objective: A novel sugar-based double-tailed surfactant containing renewable block was synthesized for preparing niosomal vesicles that could be exploited for Levofloxacin encapsulation, aiming to increase its oral bioavailability. Materials and methods: The surfactant was characterized by 1 H NMR, mass spectroscopy and Fourier transform infrared spectroscopy (FT-IR). Its biocompatibility was studied against cell cultures and human blood hemolysis. In vivo acute toxicity was evaluated in mice. The vesicle morphology, size, drug-excipients interaction and entrapment efficiency (EE) were examined using atomic force microscope (AFM), dynamic light scattering (DLS), FT-IR and HPLC. Oral bioavailability studies of Levofloxacin in surfactant-based niosomal formulation were carried out using rabbits and plasma samples were analyzed using HPLC. Results and discussion: Vesicles were spherical in shape and the size was 190.31 ± 4.51 nm with a polydispersity index (PDI) of 0.29 ± 0.03. The drug EE in niosomes was 68.28 ± 3.45%. When applied on cell lines, high cell viability was observed even after prolonged exposure at high concentrations. It caused 5.77 ± 1.34% hemolysis at 1000 mg/mL and was found to be safe up to 2000 mg/kg. Elevated Levofloxacin plasma concentration was achieved when delivered with novel vesicles. Conclusion:The surfactant was demonstrated to be safe and effective as carrier of Levofloxacin. The study suggests that this sugar-based double-tailed nonionic surfactant could be promising nano-vesicular system for delivery and enhancing oral bioavailability of the hydrophobic Levofloxacin.

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Physicochemical characterization and cytotoxic studies of nonionic surfactant vesicles using sucrose esters as oral delivery systems

Cited by 30 publications

References 50 publications

Cinnamic acid derived compounds loaded into liposomes: antileishmanial activity, production standardisation and characterisation

Cinnamic acid derived compounds loaded into liposomes: antileishmanial activity, production standardisation and characterisation

Development of a biocompatible creatinine-based niosomal delivery system for enhanced oral bioavailability of clarithromycin

Sugar-based novel niosomal nanocarrier system for enhanced oral bioavailability of levofloxacin

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