Particulate matter is a major contribution of air pollution and detrimental to human health. The in vitro antioxidant activities of a brown seaweed, Sargassum horneri ethanol extract (SHE) against particulate matterinduced oxidative stress were investigated by measuring 1,1-diphenyl-2-picrylhydrazyl (DPPH) free-radical scavenging activity, hydrogen peroxide (H 2 O 2 ) scavenging activity, superoxide anion (O 2 Á-) inhibition, hydroxyl radical ( Á OH) scavenging activity, reducing power, and the metal ion-chelating effect. All in vitro antioxidant activities were increased as the concentration of SHE increased (0-1000 lg/mL). When treated with particulate matter at 0-1000 lg/mL, the DPPH free radical, and H 2 O 2 scavenging activities, reducing power, and metal ion-chelating abilities of SHE were significantly decreased (p \ 0.05).These results indicate that Sargassum horneri, which is a rich source of bioactive compounds, can be used as a natural source of antioxidants in the food industries.