Physicochemical characteristics of chitosan-TiO2 biomaterial. 2. Wettability and biocompatibility

Ładniak, Agata; Jurak, Małgorzata; Wiącek, Agnieszka Ewa

doi:10.1016/j.colsurfa.2021.127546

Cited by 11 publications

(2 citation statements)

References 69 publications

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“…Moreover, the observed changes resulting from the mixing in the subphase, i.e., Ch with TiO 2 or HA with TiO 2 , in relation to differences caused by individual components, confirm our previous reports [18,28,[44][45][46][47]. Clearly, in the case of the AA/HA/TiO 2 subphase, TiO 2 dominates in the interactions with Langmuir film components.…”

Section: Subphasesupporting

confidence: 88%

The Influence of Polysaccharides/TiO2 on the Model Membranes of Dipalmitoylphosphatidylglycerol and Bacterial Lipids

et al. 2022

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The aim of the study was to determine the bactericidal properties of popular medical, pharmaceutical, and cosmetic ingredients, namely chitosan (Ch), hyaluronic acid (HA), and titanium dioxide (TiO2). The characteristics presented in this paper are based on the Langmuir monolayer studies of the model biological membranes formed on subphases with these compounds or their mixtures. To prepare the Langmuir film, 1,2-dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) (DPPG) phospholipid, which is the component of most bacterial membranes, as well as biological material-lipids isolated from bacteria Escherichia coli and Staphylococcus aureus were used. The analysis of the surface pressure-mean molecular area (π-A) isotherms, compression modulus as a function of surface pressure, CS−1 = f(π), relative surface pressure as a function of time, π/π0 = f(t), hysteresis loops, as well as structure visualized using a Brewster angle microscope (BAM) shows clearly that Ch, HA, and TiO2 have antibacterial properties. Ch and TiO2 mostly affect S. aureus monolayer structure during compression. They can enhance the permeability of biological membranes leading to the bacteria cell death. In turn, HA has a greater impact on the thickness of E. coli film.

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Section: Subphasesupporting

confidence: 88%

The Influence of Polysaccharides/TiO2 on the Model Membranes of Dipalmitoylphosphatidylglycerol and Bacterial Lipids

et al. 2022

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“…It is readily biodegradable into non-toxic metabolites that are completely absorbed by the human body. Chitosan also inhibits the efflux pump—it inhibits the transport of certain proteins on the membrane of intestinal epithelial cells or enterocytes that pump out xenobiotics, mainly drugs; these transporters are important elements in the mechanisms of drug resistance [ 46 , 47 , 48 , 49 , 50 ].…”

Section: Chitosan and Chnps Utilities In Drug Delivery Systems (Dds)mentioning

confidence: 99%

Chitosan-Based Nanoparticles as Effective Drug Delivery Systems—A review

et al. 2023

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Chitosan-based nanoparticles (chitosan-based nanocomposites; chitosan nanoparticles; ChNPs) are promising materials that are receiving a lot of attention in the last decades. ChNPs have great potential as nanocarriers. They are able to encapsulate drugs as well as active compounds and deliver them to a specific place in the body providing a controlled release. In the article, an overview has been made of the most frequently used preparation methods, and the developed applications in medicine. The presentation of the most important information concerning ChNPs, especially chitosan’s properties in drug delivery systems (DDS), as well as the method of NPs production was quoted. Additionally, the specification and classification of the NPs’ morphological features determined their application together with the methods of attaching drugs to NPs. The latest scientific reports of the DDS using ChNPs administered orally, through the eye, on the skin and transdermally were taken into account.

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