2013
DOI: 10.5897/ajpp2012.1508
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Physicochemical characterisation of Irvingia wombolu gum in tramadol encapsulated granules

Abstract: The objectives of the work were to evaluate the binder properties of gum from Irvingia wombolu seed cotyledons and to compare with sodium carboxymethylcellulose (SCMC) in tramadol encapsulated granules. Tramadol granules was formulated by wet granulation using gum derived from the seed cotyledons of I. wombolu as binder at concentrations of 2.5, 5.0, 7.5, 10.0 and 15.0% w/w. The binder properties of the gum were compared with that of SCMC. The flow properties of the granules were studied by direct and indirect… Show more

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Cited by 5 publications
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“…This mucilage is starch based. There was also an attempt by Ikechukwu and Salome [12] to evaluate the possibility of using gum from IW kernels in the tramadol capsule production. The authors concluded that the gum has good potential to be used in producing normal tramadol capsules.…”
Section: Introductionmentioning
confidence: 99%
“…This mucilage is starch based. There was also an attempt by Ikechukwu and Salome [12] to evaluate the possibility of using gum from IW kernels in the tramadol capsule production. The authors concluded that the gum has good potential to be used in producing normal tramadol capsules.…”
Section: Introductionmentioning
confidence: 99%