Physicochemical, biological, and antibacterial evaluation of tricalcium silicate-based reparative cements with different radiopacifiers

Queiroz, Marcela Borsatto; Torres, Fernanda Ferrari Esteves; Rodrigues, Érico; Viola, Kennia Scapin; Bosso‐Martelo, Roberta; Chávez-Andrade, Gisselle Moraima; Guerreiro-Tanomaru, Juliane Maria; Tanomaru‐Filho, Mário

doi:10.1016/j.dental.2020.11.014

Cited by 35 publications

(46 citation statements)

References 38 publications

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“…It was demonstrated that novel experimental cement ALBO-DENT performed satisfactory behavior in cell culture, comparable to that of PC and MTA. Presented results showed significantly lower percentage of viable cells in MTA/PC treatments than those found in some studies (80-150%) [7,33,34], but they are in agreement with other studies [35,36]. For PC/ MTA 1:2 and 1:4 eluents, the CV and MTT tests showed similar outcomes and are in rough agreement with data documented in the literature [7,37].…”

Section: Discussionsupporting

confidence: 91%

“…Presented results showed significantly lower percentage of viable cells in MTA/PC treatments than those found in some studies (80-150%) [7,33,34], but they are in agreement with other studies [35,36]. For PC/ MTA 1:2 and 1:4 eluents, the CV and MTT tests showed similar outcomes and are in rough agreement with data documented in the literature [7,37]. The differences of cell viability results in different studies could arise from variations in specimens' size (5×3 mm [37], 5×2 mm [12] and 5×1 mm [29]).…”

Section: Discussioncontrasting

confidence: 60%

“…Iz tog razloga istraživači primenjuju različite alternative u cilju zadovoljavanja ISO 6876 zahteva za radiokontrast. Kao rendgenkontrasti korišćeni su barijum-sulfat (BaSO 4 ) [4,5], titanijum-dioksid (TiO 2 ) [4], zlato (Au) [4,5], kalcijum-volframat (CaWO 4 ) [6,7], cirkonijum-dioksid (ZrO 2 ) [8,9,10], iterbijum-fluorid (YbF 3 ) [9], tantal-pentoksid (Ta 2 O 5 ) [10] i niobijum-pentoksid (Nb 2 O 5 ) [11,12].…”

Section: Acknowledgesunclassified

“…Therefore, researchers use different alternatives aiming to meet the ISO 6876 requirement for radiopacity. The following radiopaque agents are employed previously: barium sulphate (BaSO 4 ) [4,5], titanium dioxide (TiO 2 ) [4], gold (Au) [4,5], calcium tungstate (CaWO 4 ) [6,7], zirconium dioxide (ZrO 2 ) [8,9,10], ytterbium fluoride (YbF 3 ) [9], tantalum pentoxide (Ta 2 O 5 ) [10] and niobium pentoxide (Nb 2 O 5 ) [11,12].…”

Section: Introductionmentioning

confidence: 99%

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Investigation of the radiopacity and cytotoxicity of albodent - novel strontium carbonate incorporated calcium silicate based dental cement

et al. 2021

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Introduction. Calcium silicate (CS) dental cements have numerous clinical indications in dentistry including pulp capping, root end surgery, perforation repair and apexification/apexogenesis treatment. Materials and methods. Novel CS based dental cement with incorporation of SrCO3 radiopacifier named ALBO-DENT was used as an experimental cement material while Portland cement (Aalborg, Denmark) and ProRoot MTA (Tulsa Dental, USA) were used as controls. The radiopacity evaluation was performed using digital Trophy Radiographic system with an intention to precisely determine the minimum of radiopaque agent needed to confer to ISO radiopacity requirement. Thereafter, biocompatibility of material was tested in in vitro conditions in mouse fibrosarcoma L929 cell culture treated with materials? extracts. Cell morphology was observed using phase-contrast microscopy, while cell viability was measured using crystal violet (CV) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assays. Results. Radiopacity evaluation revealed that 30%wt addition of SrCO3 was necessary to achieve satisfactory radiopacity (3.45 mm Al). Cytotoxicity analysis using CV and MTT assays revealed that pure extracts of ALBO-DENT presented superior biocompatibility when compared to PC and MTA controls while serial dilutions of experimental cements? extracts as well as that of PC and MTA did not influence L929 cell viability. Conclusions. Novel formulation of CS cement - ALBO-DENT presented satisfactory radiopacity and adequate biocompatibility.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 60%

Section: Acknowledgesunclassified

Section: Introductionmentioning

confidence: 99%

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Investigation of the radiopacity and cytotoxicity of albodent - novel strontium carbonate incorporated calcium silicate based dental cement

et al. 2021

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“…A number of studies have shown that biomaterials that have high solubility require more time for their complete setting [27,[50][51][52]. Thus, this high solubility can influence the quality of root canal treatment and increase microbial infiltration over time [33]. Calcium silicate-based endodontic sealers are currently commercially presented in ready-to-use or powder/liquid formulas.…”

Section: Root Canal Filling Materials (Sealers)mentioning

confidence: 99%

Antimicrobial Activity of Calcium Silicate-Based Dental Materials: A Literature Review

et al. 2021

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Endodontic biomaterials have significantly improved dental treatment techniques in several aspects now that they can be used for vital pulp treatments, as temporary intracanal medication, in definitive fillings, in apical surgeries, and for regenerative procedures. Calcium silicate-based cement is a class of dental material that is used in endodontics in direct contact with the dental structures, connective tissue, and bone. Because the material interacts with biological tissues and stimulates biomineralization processes, its properties are of major importance. The main challenge in endodontic treatments is the elimination of biofilms that are present in the root canal system anatomical complexities, as it remains even after chemical-mechanical preparation and disinfection procedures. Thus, an additional challenge for these biomaterials is to exert antimicrobial activity while maintaining their biological properties in parallel. This article reviews the literature for studies considering the antimicrobial properties of calcium silicate-based dental biomaterials used in endodontic practice. Considering the reviewed studies, it can be affirmed that the reduced antimicrobial effect exhibited by calcium silicate-based endodontic materials clearly emphasizes that all clinical procedures prior to their use must be carefully performed. Future studies for the evaluation of these materials, and especially newly proposed materials, under poly-microbial biofilms associated with endodontic diseases will be necessary.

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Nanocomposites and Other Restorative Materials

Tan¹,

Lyu²

2023

Nanomaterials in Dental Medicine

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Physicochemical, biological, and antibacterial evaluation of tricalcium silicate-based reparative cements with different radiopacifiers

Cited by 35 publications

References 38 publications

Investigation of the radiopacity and cytotoxicity of albodent - novel strontium carbonate incorporated calcium silicate based dental cement

Investigation of the radiopacity and cytotoxicity of albodent - novel strontium carbonate incorporated calcium silicate based dental cement

Antimicrobial Activity of Calcium Silicate-Based Dental Materials: A Literature Review

Nanocomposites and Other Restorative Materials

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