Physicochemical Basis of Increased Bioavailability of a Poorly Water-Soluble Drug following Oral Administration as Organic Solutions

Development of clinical dosage forms for a poorly water soluble drug I: Application of polyethylene glycol–polysorbate 80 solid dispersion carrier system

“…Although PEG 3350 and polysorbate 80 may not be miscible in all proportions, 22 the amount of water used as the dissolution medium was sufficient to dissolve all of the PEG 3350 and polysorbate 80 in the formulation to create a clear solution. 23 The milky color in the dissolution medium can thus be attributed to the active material being dispersed into very fine particles. The filtration of the dissolution medium revealed that approximately 20% of the drug passed through the 0.22 mm filter, and the concentration of drug in the filtrate remained practically the same whether a 0.22 or a 0.45 mm filter was used.…”

Engineering cocrystal solubility, stability, and pHmax by micellar solubilization

“…100, 5219-5234 (2011) © 2011 Wiley-Liss, Inc. and the American Pharmacists Association commonly used in cocrystal dissolution studies and formulations, [6][7][8] and the role of micelles in drug solubilization is widely appreciated in the literature, [9][10][11][12][13][14] their role in cocrystal solubility has been virtually unexplored.…”

Physicochemical Characterization of Simulated Intestinal Fed-State Fluids Containing Lyso-Phosphatidylcholine and Cholesterol

“…S mall intestinal fluid contains various endogenous surfactants, including bile salts (BS) and phospholipids (PL), which form mixed micelles with high solubilizing capacity for many poorly soluble drugs (1,2). In general, mean fasted-state BS concentrations typically range from 1.5 to 6 mM (3,4), while mean postprandial concentrations typically range from 5 to 25 mM depended on the composition of the meal (5,6).…”