Physicochemical, antioxidant properties of carotenoids and its optoelectronic and interaction studies with chlorophyll pigments

Srivastava, Ruby

doi:10.1038/s41598-021-97747-w

Cited by 30 publications

(23 citation statements)

References 72 publications

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“…These results suggest that there is a direct relationship between the oscillator strength and the exciton diffusion, e.g., system 2 exhibits a significant hole population localized over the DHN fragment, which relates to an oscillator strength value larger than unity. This is a typical signature of the main energy absorption of carotenoid systems when their photophysical properties are studied with quantum mechanical methods. − It is noteworthy that the more delocalized the exciton between the BChl- b fragments is, the larger their corresponding oscillator strength value, as it is noted for systems 4 , 6 , 7 , 9 , and 10 .…”

Section: Resultsmentioning

confidence: 93%

Electronic Structure Effects Related to the Origin of the Remarkable Near-Infrared Absorption of Blastochloris viridis’ Light Harvesting 1-Reaction Center Complex

Mondragón-Solórzano

Sandoval‐Lira

Nochebuena

et al. 2022

J. Chem. Theory Comput.

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Various photosynthetic organisms have evolved to absorb light in different regions of the visible light spectrum, thus adapting to the various lighting conditions available on Earth. While most of these autotrophic organisms absorb wavelengths around the 700−800 nm region, some are capable of red-shifted absorptions above this range, but none as remarkably as Blastochloris viridis whose main absorption is observed at 1015 nm, approximately 220 nm (0.34 eV) lower in energy than their main constituent pigments, BChl-b, whose main absorption is observed at 795 nm. The structure of its light harvesting 1-reaction center was recently elucidated by cryo-EM; however, the electronic structure details behind this red-shifted absorption remain unattended. We used hybrid quantum mechanics/molecular mechanics (QM/MM) calculations to optimize one of the active centers and performed classical molecular dynamics (MD) simulations to sample conformations beyond the optimized structure. We did excited state calculations with the timedependent density functional theory method at the CAM-B3LYP/cc-pVDZ level of theory. We reproduced the near IR absorption by sequentially modifying the number of components involved in our systems using representative structures from the calculated MD ensemble. Natural transition orbital analysis reveals the participation of the BChl-b fragments to the main transition in the native structure and the structures obtained from the QM/MM and MD simulations. H-bonding pigment−protein interactions play a role on the conformation stabilization and orientation; however, the bacteriochlorin ring conformations and the exciton delocalization are the most relevant factors to explain the red-shifting phenomenon.

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Section: Resultsmentioning

confidence: 93%

Electronic Structure Effects Related to the Origin of the Remarkable Near-Infrared Absorption of Blastochloris viridis’ Light Harvesting 1-Reaction Center Complex

Mondragón-Solórzano

Sandoval‐Lira

Nochebuena

et al. 2022

J. Chem. Theory Comput.

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“…Previous research indicated that the pro-oxidation effect of carotenoids may be due to the imbalance in the cellular redox state, an excessive concentration of carotenoids, or an excessively high oxygen partial pressure [43]. Carotenoids are antioxidants that slow down or stop the chain of free radical reactions when oxygen saturation is low [44]. Nevertheless, when the oxygen concentration was high, carotenoid radicals were vulnerable to automatic oxidation by reacting with molecular oxygen while becoming aggressive carotenoid peroxy radicals, which promoted the lipid peroxidation and the oxidative damage of other biomolecules (such as DNA and proteins) [45].…”

Section: The Explanation Of Antioxidation and Pro-oxidation Effectsmentioning

confidence: 99%

The Antioxidant and Anti-Inflammatory Effects of the Main Carotenoids from Tomatoes via Nrf2 and NF-κB Signaling Pathways

Ba,

Xu,

Deng

et al. 2023

Nutrients

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Oxidative stress and inflammation are crucial factors in the development of cardiovascular diseases. In previous research, the oxidative stress and inflammation models have frequently been explored independently. In the current study, we investigated the antioxidant and anti-inflammatory effects of tomato extract and its two main carotenoids (lutein and lycopene) with various concentrations using a rat cardiomyocyte model of co-existing oxidative stress and persistent chronic inflammation. It was discovered that the antioxidant effects of 0.5–5 μM lutein, 0.5–5 μM lycopene, and 50–200 μg/mL tomato extract increased in a dose-dependent manner. However, the pro-oxidation effects emerged by measuring the antioxidant-related indices, including the levels of ROS, SOD, and GPX in H9c2 cells as concentrations exceeded those mentioned above. The anti-inflammatory effects of lutein, lycopene, and tomato extract were simultaneously strengthened with higher concentrations, potentially due to the suppression of the NF-κB signaling pathway. Furthermore, high concentrations of lutein, lycopene, and tomato extract potentially regulated Nrf2/HO-1 and NF-κB signaling pathways dependent on TGF-1β and IL-10 to demonstrate high concentrations of pro-oxidation and anti-inflammation effects. Our findings indicate that the dose–effect regulatory mechanisms of antioxidant and anti-inflammatory properties among lutein, lycopene, and tomato extract will be advantageous in developing more effective therapeutic strategies to prevent cardiovascular diseases.

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“…Oxygen atoms are also present in the ring structure as hydroxyl or epoxide groups. Carotenoids typically have well-defined three-peaked absorption spectra, although epoxidation can change the absorption maxima depending on where double bonds are located in the ring [ 22 , 23 , 24 ].…”

Section: An Overview Of Microalgal Carotenoidsmentioning

confidence: 99%

Microalgal Carotenoids: Therapeutic Application and Latest Approaches to Enhance the Production

Sirohi

Verma²,

Singh

et al. 2022

CIMB

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Microalgae are microscopic photosynthetic organisms frequently found in fresh and marine water ecosystems. Various microalgal species have been considered a reservoir of diverse health-value products, including vitamins, proteins, lipids, and polysaccharides, and are broadly utilized as food and for the treatment of human ailments such as cancer, cardiovascular diseases, allergies, and immunodeficiency. Microalgae-derived carotenoids are the type of accessory pigment that possess light-absorbing potential and play a significant role in metabolic functions. To date, nearly a thousand carotenoids have been reported, but a very less number of microalgae have been used for the commercial production of carotenoids. This review article briefly discussed the carotenoids of microalgal origin and their therapeutic application. In addition, we have briefly compiled the optimization of culture parameters used to enhance microalgal carotenoid production. In addition, the latest biotechnological approaches used to improve the yields of carotenoid has also been discussed.

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Physicochemical, antioxidant properties of carotenoids and its optoelectronic and interaction studies with chlorophyll pigments

Cited by 30 publications

References 72 publications

Electronic Structure Effects Related to the Origin of the Remarkable Near-Infrared Absorption of Blastochloris viridis’ Light Harvesting 1-Reaction Center Complex

Electronic Structure Effects Related to the Origin of the Remarkable Near-Infrared Absorption of Blastochloris viridis’ Light Harvesting 1-Reaction Center Complex

The Antioxidant and Anti-Inflammatory Effects of the Main Carotenoids from Tomatoes via Nrf2 and NF-κB Signaling Pathways

Microalgal Carotenoids: Therapeutic Application and Latest Approaches to Enhance the Production

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