Physicochemical and structural characterization of a polyionic matrix of interest in biotechnology, in the pharmaceutical and biomedical fields

Magnin, Delphine; Jacques, Laurent; Chornet, E.; Dumitriu, Severian

doi:10.1016/j.carbpol.2003.11.013

Cited by 68 publications

(21 citation statements)

References 36 publications

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“…One such example is coacervating polyanionic xanthan with polycationic chitosan (Esteban & Severian, 2000;1999). Proteins below its isoelectric point are positively charged and likely to associate with anionic hydrocolloids and form polyion complex hydrogel (complex coacervate) (Magnin et al, 2004). …”

Section: Complex Coacervationmentioning

confidence: 99%

Hydrogels: Methods of Preparation, Characterisation and Applications

Gulrez¹,

Al-Assaf²,

Phillips³

2011

Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications

255

178

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Section: Complex Coacervationmentioning

confidence: 99%

Hydrogels: Methods of Preparation, Characterisation and Applications

Gulrez¹,

Al-Assaf²,

Phillips³

2011

Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications

255

178

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“…γ-Polyglutamic acid (γ-PGA), found in natto, a traditional Japanese fermented food, is a non-toxic, edible and anionic polypeptide [20]. Gelatin and γ-PGA at a pH = 7.4 aqueous solution can form a polycation and polyanion, respectively, which, by ionic interaction, will form polyion complex insoluble hydrogels [21].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Gelatin-γ-Polyglutamic Acid-Based Hydrogel for the In Vitro Controlled Release of Epigallocatechin Gallate (EGCG) from Camellia sinensis

et al. 2013

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Abstract:The antioxidant property and other health benefits of the most abundant catechin, epigallocatechin gallate (EGCG), are limited because of poor stability and permeability across intestine. Protecting the EGCG from the harsh gastrointestinal tract (GIT) environment can help to increase its bioavailability following oral administration. In this study, EGCG was loaded to hydrogel prepared from ionic interaction between an optimized concentration of gelatin and γ-polyglutamic acid (γ-PGA), with ethylcarbodiimide (EDC) as the crosslinker. Physicochemical characterization of hydrogel was done using Fourier transform-infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The dependence of the swelling degree (SD) of the hydrogel to the amount of gelatin, γ-PGA, EDC, swelling time and pH was determined. A high SD of the crosslinked hydrogel was noted at pH 4.5, 6.8 OPEN ACCESSPolymers 2014, 6 40 and 9.0 compared to pH 7.4, which describes pH-responsiveness. Approximately 67% of the EGCG from the prepared solution was loaded to the hydrogel after 12 h post-loading, in which loading efficiency was related to the amount of EDC. The in vitro release profile of EGCG at pH 1.2, 6.8 and 7.4, simulating GIT conditions, resulted in different sustained release curves. Wherein, the released EGCG was not degraded instantly compared to free-EGCG at controlled temperature of 37 °C at different pH monitored against time. Therefore, this study proves the potential of pH-responsive gelatin-γ-PGA-based hydrogel as a biopolymer vehicle to deliver EGCG.

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“…When all surrounding water molecules are oriented in this fashion, a polyelectrolyte hydrogel is obtained. Reprinted from Dumitriu et al [141]. Copyright 2004 Elsevier molecular-weight chitosan decreased from 3,000 to 2,500 %; this trend progressed with the gels prepared after 24 h of coacervation time, with mass-swelling degrees of 250 % in case of the low molecular-weight chitosan and 1,000 % in case of the high molecular-weight chitosan, as compiled in Fig.…”

Section: Hydrogels Crosslinked By Ionic Interactionsmentioning

confidence: 60%

Section: Hydrogels Crosslinked By Ionic Interactionsmentioning

confidence: 96%

“…However, little was known about how the composition of the precursor polymers influences the properties of these hydrogels. To close this gap, Dumitriu and coworkers investigated the swelling properties, microstructure, and mechanical traits of chitosan-xanthan hydrogels [141]. Mixing aqueous solutions of anionic xanthan and cationic chitosan forms hydrogels in a multistep process: after mixing, a common solution-pH value is established, causing structural changes of the polymer chains.…”

Section: Hydrogels Crosslinked By Ionic Interactionsmentioning

confidence: 99%

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Polymeric Supramolecular Hydrogels as Materials for Medicine

Hackelbusch

Seiffert

2014

In-Situ Gelling Polymers

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This chapter describes some recent research in the field of supramolecular polymeric hydrogels. Eight examples are discussed that represent a small view of the plethora of these advanced functional materials. The examples described herein exhibit tunable physicochemical properties that allow for adjustment towards targeted applications in the biomedical field, including protein immobilization, tissue engineering, drug delivery, and dermocosmetics. The highly adaptive supramolecular polymeric hydrogels are likely to have a bright future as materials for medicine.

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Physicochemical and structural characterization of a polyionic matrix of interest in biotechnology, in the pharmaceutical and biomedical fields

Cited by 68 publications

References 36 publications

Hydrogels: Methods of Preparation, Characterisation and Applications

Hydrogels: Methods of Preparation, Characterisation and Applications

Synthesis of Gelatin-γ-Polyglutamic Acid-Based Hydrogel for the In Vitro Controlled Release of Epigallocatechin Gallate (EGCG) from Camellia sinensis

Polymeric Supramolecular Hydrogels as Materials for Medicine

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