Physicochemical and release properties of pellets coated with Kollicoat® SR 30 D, a new aqueous polyvinyl acetate dispersion for extended release

Dashevsky, Andrei; Wagner, K.; Kolter, Karl; Bodmeier, Roland

doi:10.1016/j.ijpharm.2004.10.024

Cited by 72 publications

(26 citation statements)

References 16 publications

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“…Delayed release formulae (EFS formulae) were used for coating so as to produce delayed release coated acetylsalicylic acid tablets with different types and concentrations of antiadherents; these formulae were chosen for coating as most of the coated tablets in the market are delayed release especially for patients with gastric implications from immediate release tablets (33). The coated tablets were then examined physically for cracks, air bubbles, or fissures and cured in an oven at 40°C for 24 h to allow coalescence of the film coating (34).…”

Section: Coating Of Acetylsalicylic Acid Tabletsmentioning

confidence: 99%

Effect of Antiadherents on the Physical and Drug Release Properties of Acrylic Polymeric Films

et al. 2015

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Abstract. Antiadherents are used to decrease tackiness of a polymer coating during both processing and subsequent storage. Despite being a common excipient in coating formulae, antiadherents may affect mechanical properties of the coating film as well as drug release from film-coated tablets, but how could addition of antiadherents affect these properties and to what extent and is there a relation between the physical characteristics of the tablet coat and the drug release mechanisms? The aim of this study was to evaluate physical characteristics of films containing different amounts of the antiadherents talc, glyceryl monostearate, and PlasACRYL TM T20. Eudragit RL30D and Eudragit RS30D as sustained release polymers and Eudragit FS30D as a delayed release material were used. Polymer films were characterized by tensile testing, differential scanning calorimetry (DSC), microscopic examination, and water content as calculated from loss on drying. The effect of antiadherents on in vitro drug release for the model acetylsalicylic acid tablets coated with Eudragit FS30D was also determined. Increasing talc concentration was found to decrease the ability of the polymer films to resist mechanical stress. In contrast, glyceryl monostearate (GMS) and PlasACRYL produced more elastic films. Talc at concentrations higher than 25% caused negative effects, which make 25% concentration recommended to be used with acrylic polymers. All antiadherents delayed the drug release at all coating levels; hence, different tailoring of drug release may be achieved by adjusting antiadherent concentration with coating level.

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Section: Coating Of Acetylsalicylic Acid Tabletsmentioning

confidence: 99%

Effect of Antiadherents on the Physical and Drug Release Properties of Acrylic Polymeric Films

et al. 2015

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“…The previously reported Tg reduction after the PVA-PEG addition (32,33) might be the reason for the observed positive effect on the storage stability and played definitely a major role during storage of PVAc/ PVA-PEG films. A faster release during storage, as mentioned in the previous section, can also be caused by drug migration into the film coat (3,8,15), which was investigated by CRM. In a previous article, the EDX technique was used for a similar purpose (19).…”

Section: Long Term Stability After 6 Monthsmentioning

confidence: 99%

“…Some frequently used polymers for modified release, like ethyl cellulose (EC), show a high brittleness and weak resistance to mechanical forces (2). An advantageous high flexibility has been demonstrated for poly(vinyl acetate) (PVAc), a water insoluble polymer for modified release applications (3,4). Dashevsky et al investigated the compressibility of propranolol pellets, coated with PVAc or EC, with and without plasticizer (5).…”

Section: Introductionmentioning

confidence: 99%

Safety and Robustness of Coated Pellets: Self-Healing Film Properties and Storage Stability

et al. 2009

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“…Many excipients in the coating formulation can affect this parameter 23 and, in some cases, the MFT may be below room temperature. 24 …”

Section: Minimum Film Forming Temperaturementioning

confidence: 99%

Characterization of coating systems

Felton

2007

AAPS PharmSciTech

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Polymeric film coatings have been applied to solid substrates for decorative, protective, and functional purposes. Irrespective of the reasons for coating, certain properties of the polymer films may be determined as a method to evaluate coating formulations, substrate variables, and processing conditions. This article describes experimental techniques to assess various properties of both free and applied films, including water vapor and oxygen permeability, as well as thermal, mechanical, and adhesive characteristics. Methods to investigate interfacial interactions are also presented.

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Physicochemical and release properties of pellets coated with Kollicoat® SR 30 D, a new aqueous polyvinyl acetate dispersion for extended release

Cited by 72 publications

References 16 publications

Effect of Antiadherents on the Physical and Drug Release Properties of Acrylic Polymeric Films

Effect of Antiadherents on the Physical and Drug Release Properties of Acrylic Polymeric Films

Safety and Robustness of Coated Pellets: Self-Healing Film Properties and Storage Stability

Characterization of coating systems

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