Physicochemical and powder properties of alpha- and microcrystalline-cellulose derived from maize cobs

Audu-Peter, Jennifer D.; Ojile, Joseph E; Bhatia, P. G.

doi:10.4314/jpb.v1i1.32047

Cited by 8 publications

(8 citation statements)

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“…The amount of water sorbed was calculated from the weight difference. [12] Loss on Drying Five grams of powder samples were transferred, each, into a Petri dish and then dried in an oven at 105°C until a constant weight was obtained. The percentage moisture loss was then determined as the ratio of weight of moisture to weight of sample expressed as percentage.…”

Section: Swelling Capacitymentioning

confidence: 99%

Processing pharmaceutical grade microcrystalline cellulose from groundnut husk: Extraction methods and characterization

Ohwoavworhua¹,

Adelakun²,

Okhamafe³

2009

Int J Green Pharm

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Section: Swelling Capacitymentioning

confidence: 99%

Processing pharmaceutical grade microcrystalline cellulose from groundnut husk: Extraction methods and characterization

Ohwoavworhua¹,

Adelakun²,

Okhamafe³

2009

Int J Green Pharm

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“…Some workers [194] sourced and obtained cellulose and microcrystalline cellulose from maize cobs and they compared the tablet properties of paracetamol tablets made by direct compression with microcrystalline cellulose (MCC) as sole excipients with a multiexcipient formula in wet granulation and found that the former possesses better tablet properties apart from the added advantages of direct compression and fewer ingredients. Scientists have evaluated the physicochemical and powder properties of alpha-and microcrystalline cellulose derived from maize cobs and they found that it has comparable attributes to Avicel® as a pharmaceutical excipient [195].…”

Section: Starchesmentioning

confidence: 99%

Advances in Natural Polymers as Pharmaceutical Excipients

Ogaji¹,

Nep²,

Audu-Peter³

2012

Pharm Anal Acta

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Research in natural polymeric materials has witnessed growing interest and attention. This is attributable to a number of factors which include their relative abundance, low cost, and biodegrable and eco-firendly profiles. This article reviews the current applications of natural polymeric materials in pharmaceutical formulations. The pharmaceutical applications of some of the traditional and commercially available natural polymers were discussed. Emerging potential pharmaceutical excipients of natural origins were also discussed. The increasing research interests in this group of materials are indications of their increasing importance. It is believed that as technology and testing techniques advance, more understanding of their physicochemical nature would be gained that can enable them to be tailored for wider Pharmaceutical applications than their synthetic counterparts.

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“…Where w is the weight of powder, SG is specific gravity of solvent, a is weight of bottle + solvent and b is weight of bottle + solvent + powder 10,11 .…”

Section: Powder Propertiesmentioning

confidence: 99%

“…As part of on-going efforts to develop local raw materials for the pharmaceutical industry, we have in the present work, obtained low crystallinity cellulose from the α-cellulose derived from corn cob. Corn cob waste has been identified in various studies as a potential source of cellulose 10,11 . The α-and low crystallinitycelluloses (coded AC-CC and LCC-CC, respectively) obtained were assessed for their physicochemical properties.…”

Section: Introductionmentioning

confidence: 99%

Phosphoric Acid-Mediated Depolymerization and Decrystallization of α-Cellulose Obtained from Corn Cob: Preparation of Low Crystallinity Cellulose and Some Physicochemical Properties

Ohwoavworhua¹,

Adelakun²

2007

Trop. J. Pharm Res

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Purpose: Low crystallinity celluloses (LCC) are materials that have a substantially reduced degree of crystallinity, typically ranging between 15 and 45%. It is useful as an excipient in preparation of tablets and confectionery products. The aim of this work was to obtain from αcellulose content of corn cob, a low crystallinity cellulose (LCC-CC), and study its physical properties as well as evaluation of its potential as tablet excipient. Methods: α-cellulose (AC-CC) obtained from corn cob by a delignification process, was depolymerized with 85% phosphoric acid to yield LCC-CC product, whose physical properties were compared with those of AC-CC. Results: The yield of AC-CC and LCC-CC were 14 and 11 %, respectively. The physical properties indicated a good level of purity of the cellulose materials as they conform to British Pharmacopoeia specifications. The flow indices, however, showed that these materials flowed poorly. Conclusion:It was concluded that LCC-CC is a potential disintegrant and filler-diluent, in pharmaceutical tableting.

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Physicochemical and powder properties of alpha- and microcrystalline-cellulose derived from maize cobs

Cited by 8 publications

References 0 publications

Processing pharmaceutical grade microcrystalline cellulose from groundnut husk: Extraction methods and characterization

Processing pharmaceutical grade microcrystalline cellulose from groundnut husk: Extraction methods and characterization

Advances in Natural Polymers as Pharmaceutical Excipients

Phosphoric Acid-Mediated Depolymerization and Decrystallization of α-Cellulose Obtained from Corn Cob: Preparation of Low Crystallinity Cellulose and Some Physicochemical Properties

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