Physicochemical and nanomedicine applications of phyto-reduced erbium oxide (Er2O3) nanoparticles

Abstract

Hyphaene thebaica fruits were used for the fabrication of spherical erbium oxide nanoparticles (HT-Er2O3 NPS) using a one-step simple bioreduction process. XRD pattern revealed a highly crystalline and pure phase with crystallite size of ~ 7.5 nm, whereas, the W–H plot revealed crystallite size of 11 nm. FTIR spectra revealed characteristic Er-O atomic vibrations in the fingerprint region. Bandgap was obtained as 5.25 eV using K-M function. The physicochemical and morphological nature was established using Raman spectroscopy, reflectance spectroscopy, SAED and HR-TEM. HT-Er2O3 NPS were further evaluated for antidiabetic potential in mice using in-vivo and in-vitro bioassays. The synthesized HT-Er2O3 NPS were screened for in vitro anti-diabetic potentials against α-glucosidase enzyme and α-amylase enzyme and their antioxidant potential was evaluated using DPPH free radical assay. A dose dependent inhibition was obtained against α-glucosidase (IC50 12 μg/mL) and α-amylase (IC50 78 μg/mL) while good DPPH free radical scavenging potential (IC50 78 μg mL−1) is reported. At 1000 μg/mL, the HT-Er2O3 NPS revealed 90.30% and 92.30% inhibition of α-amylase and α-glucosidase enzymes. HT-Er2O3 NPs treated groups were observed to have better glycemic control in diabetic animals (503.66 ± 5.92*** on day 0 and 185.66 ± 2.60*** on day 21) when compared with positive control glibenclamide treated group. Further, HT-Er2O3 NPS therapy for 21 days caused a considerable effect on serum total lipids, cholesterol, triglycerides, HDL and LDL as compared to untreated diabetic group. In conclusion, our preliminary findings on HT-Er2O3 NPS revealed considerable antidiabetic potential and thus can be an effective candidate for controlling the post-prandial hyperglycemia. However, further studies are encouraged especially taking into consideration the toxicity aspects of the nanomaterial.

Phyto-fabrication of ultrafine nanoscale holmium oxide HT-Ho2O3 NPs and their biomedical potential

“… 23 ), BiVO 4 , 45 ZnO, 46 CuO, 47 Er 2 O 3 (ref. 48 ) and Ag nanoparticles 20 . The biosynthesis of holmium oxide nanoparticles is reported for the 1st time.…”

“…Like other sesquioxides, Ho 2 O 3 is used in various applications including optical applications such as calibration of the wavelength in instruments, pyrolysis, catalysis, electrochemical sensing, memory devices etc. [1][2][3] The basic and catalytic properties of Ho 2 O 3 are reliant on the fabrication methods. 4 In the REMs, Ho 2 O 3 NPs are known for elevated lattice energy and a large magnetic moment.…”

Lanthanide-Doped ZnO Nanoparticles: Unraveling Their Role in Cytotoxicity, Antioxidant Capacity, and Nanotoxicology

“…In therapeutic applications, lanthanide-doped nanoparticles have been reported to target neurological diseases and possess biocompatibility with treatment regimens such as chemotherapy and radiotherapy [15,16]. In comparison to other nanostructures derived from lanthanide elements, lanthanum oxide (La 2 O 3 ) is utilized to fabricate nanostructures through a variety of physical and chemical methods and is recognized for its important biomedical uses due to its low genotoxicity, the presence of 4f shielded electrons, its biocompatibility, and its intrinsic fluorescent and magnetic features and redox-switching capacity [17]. In the same context, Sm 2 O 3 constitutes an attractive rare earth element for developing or doping materials with nanometric architectures and therapeutic applications due to its five 4f electrons, enhanced absorbance of infrared radiation, chemical stability, and catalytic activity [18].…”

Structural, vibrational, optical, and anticancer properties of Hyphaene thebaica‐reduced nano‐lanthanum oxide (La2O3)

“…Previous work indicated the anti-inflammatory, antimicrobial, antioxidant, anticancer, and antidiabetic effects of the H. thebaica. 17,18 Previously, we have reported biosynthesis of Ag NPs, 19 ZnO NPs, 20 CeO 2 NPs, 21 Fe 2 O 3 NPs, 22 BiVO 4 NRs, 23 Cr 2 O 3 NPs, 24 and Er 2 O 3 25 by applying aqueous extracts of the H. thebaica fruits and investigated their potential nanomedicinal properties like antibacterial, antioxidant, and antiviral.…”